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1.发明申请METHODS AND COMPOSITIONS FOR TREATING beta-THALASSEMIA AND SICKLE CELL DISEASE 审中-公开用于治疗β-硫胺素和LE细胞病的方法和组合物
公开(公告)号：WO2012112232A8
公开(公告)日：2013-09-26
申请号：PCT/US2012020059
申请日：2012-01-03
Applicant: ACADEMIA SINICA , SHEN CHE-KUN JAMES , CHOU YU-CHI
Inventor： SHEN CHE-KUN JAMES , CHOU YU-CHI
IPC: C07D471/04 , A61K31/4745 , A61P7/00
CPC classification number: C07D471/04 , A61K31/4745 , A61K45/06 , G01N33/5044 , A61K2300/00
Abstract: The present invention provides compounds (such as compounds of formula I-a) that induce gamma globin expression and pharmaceutical compositions thereof. Such compounds may have beneficial therapeutic effects. Compounds and compositions described herein may be used to treat hemoglobinopathies such as beta-thalassemia and sickle cell anemia. (I-a)
Abstract translation: 本发明提供诱导γ珠蛋白表达的化合物（例如式I-a的化合物）及其药物组合物。 这些化合物可能具有有益的治疗作用。 本文所述的化合物和组合物可用于治疗血红蛋白病如β-地中海贫血和镰状细胞性贫血。 （I-a）的
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2.发明申请METHODS AND COMPOSITIONS FOR TREATING BETA-THALASSEMIA AND SICKLE CELL DISEASE 审中-公开用于治疗泰沙利度胺和病毒性细胞病的方法和组合物
公开(公告)号：WO2014179567A3
公开(公告)日：2016-02-25
申请号：PCT/US2014036369
申请日：2014-05-01
Applicant: ACADEMIA SINICA
Inventor： SHEN CHE-KUN JAMES , CHOU YU-CHI , SU TSANN-LONG
IPC: C07D221/14 , A61K9/00 , A61K31/473 , A61P7/06 , C07D221/06 , C07D221/12
CPC classification number: A61K31/473 , A61K9/0053 , A61K45/06 , C07D221/14 , G01N33/5044 , G01N2333/805 , G01N2800/52 , A61K2300/00
Abstract: Compounds, pharmaceutical compositions, and methods for treating anemia β-thalassemia anemia or sickle cell anemia.
Abstract translation: 化合物，药物组合物和治疗贫血性β-地中海贫血症或镰状细胞性贫血的方法。
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3.发明公开METHODS AND COMPOSITIONS FOR TREATING -THALASSEMIA AND SICKLE CELL DISEASE 有权方法和组合物β-地中海贫血和镰状细胞病的治疗
公开(公告)号：EP2678339A4
公开(公告)日：2015-02-25
申请号：EP12747213
申请日：2012-01-03
Applicant: ACADEMIA SINICA
Inventor： SHEN CHE-KUN JAMES , CHOU YU-CHI
IPC: A61K31/4745 , A61P7/00
CPC classification number: C07D471/04 , A61K31/4745 , A61K45/06 , G01N33/5044 , A61K2300/00
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