公开(公告)号：JP2002047298A

公开(公告)日：2002-02-12

申请号：JP2000208258

申请日：2000-07-10

Applicant: ACADEMIA SINICA

Inventor： SHUI-TEIN CHEN ,  IN-TA U ,  CHUN-MIN FUAN

IPC: A61K9/127 ,  A61K38/22 ,  A61K47/48 ,  A61P35/00 ,  B01J13/02 ,  C07K7/06

Abstract: PROBLEM TO BE SOLVED: To solve the problem of toxic side action of various cytotoxic anticancer agent lacking a selective drug transfer system and to improve the transfer efficiency of drug. SOLUTION: The new system for the transfer of an anti-cancer agent to a cancer cell is produced by using a new cancer treating compound expressed by general formula paclitaxel (or PEG-DOPE)-O-R-NH-R' [R is a dicarboxylic acid residue; and R' is somatostatin analog]. The compound can be synthesized by a solid phase process.