公开(公告)号：HK1208598A1

公开(公告)日：2016-03-11

申请号：HK15109316

申请日：2015-09-23

Applicant: ACADEMIA SINICA

Inventor： CHEN CHIH-CHENG ,  LIN YUN-LIAN ,  FANG JIM-MIN ,  CHERN YIJUANG ,  LIN CHIA-CHING JOHN ,  CHEN WEI-NAN ,  LIN CHUN-JUNG

IPC: A61K20060101 ,  A01N20060101

Abstract: The invention provides a new use of adenosine analogs for the treatment of pain through activation of neurokinin 1 (NK1) receptor signaling pathway, thereby inducing the activation of activation of M-type potassium channel to induce outward currents. A method and pharmaceutical composition for treating pain comprising an adenonsine analog that activates NK1 receptor signaling, thereby inducing outward current are also provided.

公开(公告)号：EP2849566A4

公开(公告)日：2015-08-19

申请号：EP13746079

申请日：2013-02-11

Applicant: ACADEMIA SINICA

Inventor： CHEN CHIH-CHENG ,  LIN YUN-LIAN ,  FANG JIM-MIN ,  CHERN YIJUANG ,  LIN CHIA-CHING JOHN ,  CHEN WEI-NAN ,  LIN CHUN-JUNG

IPC: A01N43/04 ,  A61K31/70 ,  A61P25/04 ,  A61P29/02

CPC classification number: A61K31/7076 ,  A61K36/8988 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention provides a new use of adenosine analogs for the treatment of pain through activation of neurokinin 1 (NK1) receptor signaling pathway, thereby inducing the activation of activation of M-type potassium channel to induce outward currents. A method and pharmaceutical composition for treating pain comprising an adenonsine analog that activates NK1 receptor signaling, thereby inducing outward current are also provided.

Abstract translation: 本公开提供了腺苷类似物用于通过激活神经激肽1（NK1）受体信号传导途径治疗疼痛的新用途，从而诱导M型钾通道的活化以诱导向外的电流。 还提供了用于治疗疼痛的方法和药物组合物，其包含激活NK1受体信号传导的腺苷类似物，从而诱导外向电流。