公开(公告)号：JP2002338502A

公开(公告)日：2002-11-27

申请号：JP2001144020

申请日：2001-05-14

Applicant: ACADEMIA SINICA

Inventor： RI HYUN ,  SHEE SHUU-MEI ,  CHAN JAN-GOU

IPC: A61K48/00 ,  A61K31/16 ,  A61K31/165 ,  A61K31/19 ,  A61K31/4353 ,  A61K38/00 ,  A61K45/00 ,  A61K49/00 ,  A61P21/00 ,  A61P43/00

Abstract: PROBLEM TO BE SOLVED: To perform the treatment of vertebral amyotrophy by administering a sufficient amount of a histonacetylase inhibitor for improving the symptoms of the vertebral amyotrophy. SOLUTION: This treatment of the vertebral amyotrophy is provided by administering the sufficient amount of the histonacetylase inhibitor for increasing the expression level of SMN exon 7 in the cells of the subject based on the standard expression level of the SMN exon 7 to adjust the SMN exon 7 expression in a method for the expressing the SMN gene expression in the subject.