公开(公告)号：ZA201603118B

公开(公告)日：2019-04-24

申请号：ZA201603118

申请日：2016-05-10

Applicant: ACADEMIA SINICA

Inventor： FANG JIM-MIN ,  LIN YUN-LIAN ,  LIN JUNG-HSIN ,  LIN CHUN-JUNG ,  CHERN YIJUANG ,  HUANG NAI-KUEI ,  WANG HUNG-LI ,  TU BENJAMIN PANG-HSIEN ,  CHEN CHIH-CHENG

Abstract: Compounds for use in prevention and treatment of neurodegenerative disease and pain are disclosed. In one embodiment of the invention, the compound is selected from the group consisting of N6-[(3-halothien-2-yl)methyl]adenosine, N6-[(4-halothien-2-yl)methyl]adenosine, and N6-[(5-halothien-2-yl)methyl]adenosine. In another embodiment of the invention, the compound is selected from the group consisting of N6-[(2-bromothien-3-yl)methyl]adenosine, N6-[(4-bromothien-3-yl)methyl]adenosine, N6-[(5-bromothien-3-yl)methyl]adenosine N6-[(2-chlorothien-3-yl)methyl]adenosine, N6-[(4-chlorothien-3-yl)methyl]adenosine, and N6-[(5-chlorothien-3-yl)methyl]adenosine. Also disclosed are methods of making and using the same.

公开(公告)号：NZ719740A

公开(公告)日：2021-02-26

申请号：NZ71974014

申请日：2014-10-22

Applicant: ACADEMIA SINICA

Inventor： FANG JIM-MIN ,  LIN YUN-LIAN ,  LIN JUNG-HSIN ,  LIN CHUN-JUNG ,  CHERN YIJUANG ,  HUANG NAI-KUEI ,  WANG HUNG-LI ,  TU BENJAMIN PANG-HSIEN ,  CHEN CHIH-CHENG

IPC: C07D498/02 ,  A61P25/28 ,  C07D515/02

Abstract: Compounds for use in prevention and treatment of neurodegenerative disease and pain are disclosed. In one embodiment of the invention, the compound is selected from the group consisting of N-[(3-halothien-2-yl)methyl]adenosine, -[(4-halothien-2-yl)methyl]adenosine, and N-[(5-halothien-2-yl)methyl]adenosine. In another embodiment of the invention, the compound is selected from the group consisting of -[(2-bromothien-3-yl)methyl]adenosine, N-[(4-bromothien-3-yl)methyl]adenosine, -[(5-bromothien-3-yl)methyl]adenosine N-[(2-chlorothien-3-yl)methyl]adenosine, -[(4-chlorothien-3-yl)methyl]adenosine, and N-[(5-chlorothien-3-yl)methyl]adenosine. Also disclosed are methods of making and using the same.

公开(公告)号：BR112016008901A2

公开(公告)日：2020-05-12

申请号：BR112016008901

申请日：2014-10-22

Applicant: ACADEMIA SINICA

Inventor： CHEN CHIH-CHENG ,  CHERN YIJUANG ,  FANG JIM-MIN ,  HUANG NAI-KUEI ,  LIN CHUN-JUNG ,  LIN JUNG-HSIN ,  LIN YUN-LIAN ,  TU BENJAMIN PANG-HSIEN ,  WANG HUNG-LI

IPC: C07D498/02 ,  C07D515/02

Abstract: compostos para uso na prevenção e tratamento de doenças neurodegenerativas e da dor descrevem-se compostos para uso na prevenção e tratamento de doenças neurodegenerativas e dor. em uma forma de realização da invenção, o composto é selecionado dentre o grupo que consiste em n6-[(3-halotien-2-il)metila]adenosina, n6-[(4-halotien-2-il)metila]adenosina e n6-[(5-halotien-2-il)metila]adenosina. em outra concretização da invenção, o composto é selecionado dentre o grupo que consiste em n6-[(2-bromotien-3- il)metila]adenosina, n6-[(4-bromotien-3- il)metila]adenosina, n6-[(5-bromotien-3- il)metila[adenosina, n6-[(2-clorotien-3- il)metilaladenosina, n6-[(4-clorotien-3-il)metila]adenosina e n6-[( 5t--clorotien-3-il) meti la ] adenosina . t'e elm-se também métodos para sua produção e utilização

公开(公告)号：BR112016008901B1

公开(公告)日：2022-08-23

申请号：BR112016008901

申请日：2014-10-22

Applicant: ACADEMIA SINICA

Inventor： FANG JIM-MIN ,  LIN YUN-LIAN ,  LIN JUNG-HSIN ,  LIN CHUN-JUNG ,  CHERN YIJUANG ,  HUANG NAI-KUEI ,  WANG HUNG-LI ,  TU BENJAMIN PANG-HSIEN ,  CHEN CHIH-CHENG

IPC: C07D498/02 ,  C07D515/02

Abstract: COMPOSTOS PARA USO NA PREVENÇÃO E TRATAMENTO DE DOENÇAS NEURODEGENERATIVAS E DA DOR Descrevem-se compostos para uso na prevenção e tratamento de doenças neurodegenerativas e dor. Em uma forma de realização da invenção, o composto é selecionado dentre o grupo que consiste em N6-[(3-halotien-2-il)metila]adenosina, N6-[(4-halotien-2-il)metila]adenosina e N6-[(5-halotien-2-il)metila]adenosina. Em outra concretização da invenção, o composto é selecionado dentre o grupo que consiste em N6-[(2-bromotien-3- il)metila]adenosina, N6-[(4-bromotien-3-il)metila]adenosina, N6-[(5-bromotien-3-il)metila[adenosina, N6-[(2-clorotien-3-il)metilaladenosina, N6-[(4-clorotien-3-il)metila]adenosina e N6-[( 5t--clorotien-3-il) meti la ] adenosina . T'e elm-se também métodos para sua produção e utilização.

公开(公告)号：AU2014340114A1

公开(公告)日：2016-05-26

申请号：AU2014340114

申请日：2014-10-22

Applicant: ACADEMIA SINICA

Inventor： FANG JIM-MIN ,  LIN YUN-LIAN ,  LIN JUNG-HSIN ,  LIN CHUN-JUNG ,  CHERN YIJUANG ,  HUANG NAI-KUEI ,  WANG HUNG-LI ,  TU BENJAMIN PANG-HSIEN ,  CHEN CHIH-CHENG

IPC: C07D498/02 ,  C07D515/02

Abstract: Compounds for use in prevention and treatment of neurodegenerative disease and pain are disclosed. In one embodiment of the invention, the compound is selected from the group consisting of

公开(公告)号：CA2927699C

公开(公告)日：2022-07-05

申请号：CA2927699

申请日：2014-10-22

Applicant: ACADEMIA SINICA

Inventor： FANG JIM-MIN ,  LIN YUN-LIAN ,  LIN JUNG-HSIN ,  LIN CHUN-JUNG ,  CHERN YIJUANG ,  HUANG NAI-KUEI ,  WANG HUNG-LI ,  TU BENJAMIN PANG-HSIEN ,  CHEN CHIH-CHENG

IPC: C07H19/167 ,  A61K31/7076 ,  A61P25/28 ,  A61P29/00 ,  C07D498/02

Abstract: Compounds for use in prevention and treatment of neurodegenerative disease and pain are disclosed. In one embodiment of the invention, the compound is selected from the group consisting of N 6 -[(3-halothien-2-yl)methyl]adenosine, N 6 -[(4-halothien-2-yl)methyl]adenosine, and N 6 -[(5-halothien-2-yl)methyl]adenosine. In another embodiment of the invention, the compound is selected from the group consisting of N 6 -[(2-bromothien-3-yl)methyl]adenosine, N 6 -[(4-bromothien-3-yl)methyl]adenosine, N 6 -[(5-bromothien-3-yl)methyl]adenosine N 6 -[(2-chlorothien-3-yl)methyl]adenosine, N 6 -[(4-chlorothien-3-yl)methyl]adenosine, and N 6 -[(5-chlorothien-3-yl)methyl]adenosine. Also disclosed are methods of making and using the same.

公开(公告)号：AU2014340114B2

公开(公告)日：2018-10-18

申请号：AU2014340114

申请日：2014-10-22

Applicant: ACADEMIA SINICA

Inventor： FANG JIM-MIN ,  LIN YUN-LIAN ,  LIN JUNG-HSIN ,  LIN CHUN-JUNG ,  CHERN YIJUANG ,  HUANG NAI-KUEI ,  WANG HUNG-LI ,  TU BENJAMIN PANG-HSIEN ,  CHEN CHIH-CHENG

IPC: C07D498/02 ,  C07D515/02

Abstract: Compounds for use in prevention and treatment of neurodegenerative disease and pain are disclosed. In one embodiment of the invention, the compound is selected from the group consisting of

公开(公告)号：SG11201603063WA

公开(公告)日：2016-05-30

申请号：SG11201603063W

申请日：2014-10-22

Applicant: ACADEMIA SINICA

Inventor： FANG JIM-MIN ,  LIN YUN-LIAN ,  LIN JUNG-HSIN ,  LIN CHUN-JUNG ,  CHERN YIJUANG ,  HUANG NAI-KUEI ,  WANG HUNG-LI ,  TU BENJAMIN PANG-HSIEN ,  CHEN CHIH-CHENG

IPC: C07D498/02 ,  C07D515/02

Abstract: Compounds for use in prevention and treatment of neurodegenerative disease and pain are disclosed. In one embodiment of the invention, the compound is selected from the group consisting of N6-[(3-halothien-2-yl)methyl]adenosine, N6-[(4-halothien-2-yl)methyl]adenosine, and N6-[(5-halothien-2-yl)methyl]adenosine. In another embodiment of the invention, the compound is selected from the group consisting of N6-[(2-bromothien-3-yl)methyl]adenosine, N6-[(4-bromothien-3-yl)methyl]adenosine, N6-[(5-bromothien-3-yl)methyl]adenosine N6-[(2-chlorothien-3-yl)methyl]adenosine, N6-[(4-chlorothien-3-yl)methyl]adenosine, and N6-[(5-chlorothien-3-yl)methyl]adenosine. Also disclosed are methods of making and using the same.

公开(公告)号：CA2927699A1

公开(公告)日：2015-04-30

申请号：CA2927699

申请日：2014-10-22

Applicant: ACADEMIA SINICA

Inventor： FANG JIM-MIN ,  LIN YUN-LIAN ,  LIN JUNG-HSIN ,  LIN CHUN-JUNG ,  CHERN YIJUANG ,  HUANG NAI-KUEI ,  WANG HUNG-LI ,  TU BENJAMIN PANG-HSIEN ,  CHEN CHIH-CHENG

IPC: C07D498/02 ,  A61K31/7076 ,  A61P25/28 ,  A61P29/00

Abstract: Compounds for use in prevention and treatment of neurodegenerative disease and pain are disclosed. In one embodiment of the invention, the compound is selected from the group consisting of N 6 -[(3-halothien-2-yl)methyl]adenosine, N 6 -[(4-halothien-2-yl)methyl]adenosine, and N 6 -[(5-halothien-2-yl)methyl]adenosine. In another embodiment of the invention, the compound is selected from the group consisting of N 6 -[(2-bromothien-3-yl)methyl]adenosine, N 6 -[(4-bromothien-3-yl)methyl]adenosine, N 6 -[(5-bromothien-3-yl)methyl]adenosine N 6 -[(2-chlorothien-3-yl)methyl]adenosine, N 6 -[(4-chlorothien-3-yl)methyl]adenosine, and N 6 -[(5-chlorothien-3-yl)methyl]adenosine. Also disclosed are methods of making and using the same.