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公开(公告)号：AU2015267044A1
公开(公告)日：2016-12-15
申请号：AU2015267044
申请日：2015-05-27
Applicant: ACADEMIA SINICA
Inventor： WONG CHI-HEUY , WU CHUNG-YI
IPC: A61K39/395
Abstract: The present disclosure relates to a novel class of anti-TNFα monoclonal antibodies or antigen binding fragments comprising a homogeneous population of anti-TNFα IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-TNFα monoclonal antibodies by Fc glycoengineering. The glycoantibodies of the invention may have improved therapeutic values compared to the corresponding monoclonal antibodies that have not been glycoengineered.
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