公开(公告)号：WO2014124047A4

公开(公告)日：2014-10-02

申请号：PCT/US2014014938

申请日：2014-02-05

Applicant: ACADEMIA SINICA ,  LIANG CHI MING

Inventor： SHIH CHIAHO ,  CHEN HENG-LI ,  SU PEI-YI

IPC: A01N37/18 ,  A61K39/29 ,  A61P31/04

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/12 ,  A61K39/292 ,  C12N7/00 ,  C12N2730/10133 ,  C12N2730/10134

Abstract: A pharmaceutical composition for use in killing and/or inhibiting the growth and/or proliferation of a microorganism in a subject in need thereof, or for treating a subject afflicted with a microbial infection is disclosed. The composition comprises: (a) an effective amount of an isolated peptide, wherein the peptide comprises the arginine-rich carboxy-terminal region of hepatitis B virus core protein (HBc) and exhibits an antimicrobial activity; and (b) a pharmaceutically acceptable carrier. The peptide exhibits an activity against Gram-negative bacteria, Gram-positive bacteria, and/or fungi.

Abstract translation: 公开了用于杀死和/或抑制有需要的受试者中的微生物的生长和/或增殖或用于治疗受到微生物感染的受试者的药物组合物。 所述组合物包含：（a）有效量的分离的肽，其中所述肽包含乙型肝炎病毒核心蛋白（HBc）的富含精氨酸的羧基末端区域并显示出抗微生物活性; 和（b）药学上可接受的载体。 肽表现出对革兰氏阴性细菌，革兰氏阳性菌和/或真菌的活性。

公开(公告)号：SG11201809928VA

公开(公告)日：2018-12-28

申请号：SG11201809928V

申请日：2017-05-25

Applicant: SHIH CHIAHO ,  ACADEMIA SINICA

Inventor： SHIH CHIAHO ,  CHEN HENG-LI ,  SU PEI-YI

IPC: C07K14/005 ,  A01N37/46 ,  A01N63/00 ,  C07K7/08

Abstract: An antimicrobial peptide, the peptide comprising 2 to 20 variable domains, each variable domain is a sequence of 2 to 20 consecutive basic amino acids, wherein (a) the variable domains are separated from each other by a variable linker, (b) the variable linker can have 1 to 20 any amino acids other than two or more consecutive basic amino acids, and (c) the peptide has no more than 100 amino acids.

公开(公告)号：CA3024873A1

公开(公告)日：2017-11-30

申请号：CA3024873

申请日：2017-05-25

Applicant: SHIH CHIAHO ,  ACADEMIA SINICA

Inventor： SHIH CHIAHO ,  CHEN HENG-LI ,  SU PEI-YI

IPC: C07K14/005 ,  A01N37/46 ,  A01N63/00 ,  C07K7/08

Abstract: An antimicrobial peptide, the peptide comprising 2 to 20 variable domains, each variable domain is a sequence of 2 to 20 consecutive basic amino acids, wherein (a) the variable domains are separated from each other by a variable linker, (b) the variable linker can have 1 to 20 any amino acids other than two or more consecutive basic amino acids, and (c) the peptide has no more than 100 amino acids.

公开(公告)号：ZA201807763B

公开(公告)日：2020-10-28

申请号：ZA201807763

申请日：2018-11-19

Applicant: ACADEMIA SINICA ,  SHIH CHIAHO

Inventor： SHIH CHIAHO ,  CHEN HENG-LI ,  SU PEI-YI

Abstract: An antimicrobial peptide, the peptide comprising 2 to 20 variable domains, each variable domain is a sequence of 2 to 20 consecutive basic amino acids, wherein (a) the variable domains are separated from each other by a variable linker, (b) the variable linker can have 1 to 20 any amino acids other than two or more consecutive basic amino acids, and (c) the peptide has no more than 100 amino acids.

公开(公告)号：IL263086D0

公开(公告)日：2018-12-31

申请号：IL26308618

申请日：2018-11-18

Applicant: SHIH CHIAHO ,  ACADEMIA SINICA ,  CHEN HENG LI ,  SU PEI YI

Inventor： SHIH CHIAHO ,  CHEN HENG-LI ,  SU PEI-YI

IPC: A01N20060101

Abstract: An antimicrobial peptide, the peptide comprising 2 to 20 variable domains, each variable domain is a sequence of 2 to 20 consecutive basic amino acids, wherein (a) the variable domains are separated from each other by a variable linker, (b) the variable linker can have 1 to 20 any amino acids other than two or more consecutive basic amino acids, and (c) the peptide has no more than 100 amino acids.

公开(公告)号：AU2017270201A1

公开(公告)日：2018-11-29

申请号：AU2017270201

申请日：2017-05-25

Applicant: ACADEMIA SINICA

Inventor： SHIH CHIAHO ,  CHEN HENG-LI ,  SU PEI-YI

IPC: C07K14/005 ,  A01N37/46 ,  A01N63/00 ,  C07K7/08

Abstract: An antimicrobial peptide, the peptide comprising 2 to 20 variable domains, each variable domain is a sequence of 2 to 20 consecutive basic amino acids, wherein (a) the variable domains are separated from each other by a variable linker, (b) the variable linker can have 1 to 20 any amino acids other than two or more consecutive basic amino acids, and (c) the peptide has no more than 100 amino acids.