公开(公告)号：SG11202101274XA

公开(公告)日：2021-03-30

申请号：SG11202101274X

申请日：2019-08-30

Applicant: NATIONAL HEALTH RES INST ,  ACADEMIA SINICA

Inventor： CHEN CHIH-HAO ,  CHEN CHIUNG-TONG ,  WANG HWEI-JIUNG ,  HUANG KAI-FA ,  SHIH CHUAN

IPC: A61K31/4184 ,  A61P25/28 ,  C07D403/04

Abstract: Benzimidazole compounds of formula (I), shown below, are disclosed. The compounds are potent human glutaminyl cyclase inhibitors. Also disclosed is a pharmaceutical composition containing one of these compounds and a pharmaceutical acceptable carrier, as well as a method of treating Alzheimer's disease or Huntington's disease by administering to a subject in need thereof an effective amount of such a compound.

公开(公告)号：AU2019333295A1

公开(公告)日：2021-03-04

申请号：AU2019333295

申请日：2019-08-30

Applicant: ACADEMIA SINICA ,  NATIONAL HEALTH RES INST

Inventor： SHIH CHUAN ,  CHEN CHIH-HAO ,  CHEN CHIUNG-TONG ,  WANG HWEI-JIUNG ,  HUANG KAI-FA

IPC: A61K31/4184 ,  A61P25/28 ,  C07D403/04

Abstract: Benzimidazole compounds of formula (I), shown below, are disclosed. The compounds are potent human glutaminyl cyclase inhibitors. Also disclosed is a pharmaceutical composition containing one of these compounds and a pharmaceutical acceptable carrier, as well as a method of treating Alzheimer's disease or Huntington's disease by administering to a subject in need thereof an effective amount of such a compound.

公开(公告)号：AU2019333295B2

公开(公告)日：2021-07-29

申请号：AU2019333295

申请日：2019-08-30

Applicant: ACADEMIA SINICA ,  NATIONAL HEALTH RES INST

Inventor： SHIH CHUAN ,  CHEN CHIH-HAO ,  CHEN CHIUNG-TONG ,  WANG HWEI-JIUNG ,  HUANG KAI-FA

IPC: A61K31/4184 ,  A61P25/28 ,  C07D403/04

Abstract: Benzimidazole compounds of formula (I), shown below, are disclosed. The compounds are potent human glutaminyl cyclase inhibitors. Also disclosed is a pharmaceutical composition containing one of these compounds and a pharmaceutical acceptable carrier, as well as a method of treating Alzheimer's disease or Huntington's disease by administering to a subject in need thereof an effective amount of such a compound.

公开(公告)号：CA3109623A1

公开(公告)日：2020-03-05

申请号：CA3109623

申请日：2019-08-30

Applicant: NATIONAL HEALTH RES INST ,  ACADEMIA SINICA

Inventor： SHIH CHUAN ,  CHEN CHIH-HAO ,  CHEN CHIUNG-TONG ,  WANG HWEI-JIUNG ,  HUANG KAI-FA

IPC: A61K31/4184 ,  A61P25/28 ,  C07D403/04

Abstract: Benzimidazole compounds of formula (I), shown below, are disclosed. The compounds are potent human glutaminyl cyclase inhibitors. Also disclosed is a pharmaceutical composition containing one of these compounds and a pharmaceutical acceptable carrier, as well as a method of treating Alzheimer's disease or Huntington's disease by administering to a subject in need thereof an effective amount of such a compound.

公开(公告)号：CA3047146C

公开(公告)日：2021-08-31

申请号：CA3047146

申请日：2018-01-08

Applicant: NATIONAL HEALTH RES INST

Inventor： SHIA KAK-SHAN ,  WU CHIEN-HUANG ,  SONG JEN-SHIN ,  WANG YUN ,  SHIH CHUAN ,  CHOU MING-CHEN

IPC: C07D401/14 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/675 ,  C07D403/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07F9/6558

Abstract: Disclosed are heterocyclic compounds of Formula (l). (see formula I) Also disclosed is a pharmaceutical composition containing one of the heterocyclic compounds. Further disclosed are methods of using one of the heterocyclic compounds for mobilizing hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation, and for treating tissue injury, cancer, inflammatory disease, and autoimmune disease.

公开(公告)号：NZ759327A

公开(公告)日：2021-08-27

申请号：NZ75932718

申请日：2018-06-13

Applicant: NATIONAL HEALTH RES INST

Inventor： JIAANG WEIR-TORN ,  SHIH CHUAN ,  TSAI HUI-JEN

IPC: C07D417/14 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/506 ,  A61P35/00

Abstract: Aminothiazole compounds of Formula (I) shown below and pharmaceutical compositions containing one of such compounds. Also disclosed are methods of inhibiting a tyrosine kinase and treating cancer associated with a tyrosine kinase with one of the aminothiazole compounds.

公开(公告)号：AU2018284249B2

公开(公告)日：2021-06-24

申请号：AU2018284249

申请日：2018-06-13

Applicant: NATIONAL HEALTH RES INST

Inventor： SHIH CHUAN ,  JIAANG WEIR-TORN ,  TSAI HUI-JEN

IPC: A61K31/4439 ,  A61K31/496 ,  A61K31/506

Abstract: Aminothiazole compounds of Formula (I) shown below and pharmaceutical compositions containing one of such compounds. Also disclosed are methods of inhibiting a tyrosine kinase and treating cancer associated with a tyrosine kinase with one of the aminothiazole compounds.

公开(公告)号：AU2019277171A1

公开(公告)日：2020-12-03

申请号：AU2019277171

申请日：2019-05-29

Applicant: NATIONAL HEALTH RES INST

Inventor： SHIE FENG-SHIUN ,  HSU TSU-AN ,  SHEN SANTAI ,  SHIH CHUAN

IPC: A61K39/395 ,  A61P25/28 ,  C07K16/18 ,  C07K16/46

Abstract: An isolated antibody, comprising a light-chain CDR1 (L-CDR1) having the sequence of SEQ ID NO: 1, SEQ ID NO: 7, or SEQ ID NO: 14; a light-chain CDR2 (L-CDR2) having the sequence of SEQ ID NO: 2 or SEQ ID NO: 15; a light-chain CDR3 (L-CDR3) having the sequence of SEQ ID NO: 3, SEQ ID NO: 8, SEQ ID NO: 21, or SEQ ID NO: 24; a heavy-chain CDR1 (H-CDR1) having the sequence of SEQ ID NO: 4, SEQ ID NO: 9, SEQ ID NO: 11, SEQ ID NO: 16, or SEQ ID NO: 25; a heavy-chain CDR2 (H-CDR2) having the sequence of SEQ ID NO: 5, SEQ ID NO: 12, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 22, or SEQ ID NO: 26; and a heavy-chain CDR3 (H-CDR3) having the sequence of SEQ ID NO: 6, SEQ ID NO: 10, SEQ ID NO: 13, SEQ ID NO: 18, SEQ ID NO: 20, SEQ ID NO: 23, or SEQ ID NO: 27, wherein the antibody specifically binds to Αβ

公开(公告)号：ZA202000107B

公开(公告)日：2020-12-23

申请号：ZA202000107

申请日：2020-01-08

Applicant: NATIONAL HEALTH RES INST ,  SHIH CHUAN

Inventor： SHIH CHUAN ,  JIAANG WEIR-TORN ,  TSAI HUI-JEN

Abstract: Also disclosed are methods of inhibiting a tyrosine kinase and treating cancer associated with a tyrosine kinase with one of the aminothiazole compounds.

公开(公告)号：CA3132855A1

公开(公告)日：2020-10-15

申请号：CA3132855

申请日：2020-04-09

Applicant: NATIONAL HEALTH RES INST

Inventor： HSIEH HSING-PANG ,  LEE KUN-HUNG ,  LIN WEN-HSING ,  SHIH CHUAN

Abstract: Heterocyclic compounds of formula I shown below and pharmaceutical compositions containing one of such compounds: Also disclosed is a method of treating a condition modulated by the colony-stimulating factor-1 receptor with one of the heterocyclic compounds.