公开(公告)号：WO2017184895A3

公开(公告)日：2018-01-18

申请号：PCT/US2017028686

申请日：2017-04-20

Applicant: AELAN CELL TECH INC

Inventor： LUNYAK VICTORIA ,  TOLLERVEY JAMES ROBERT

IPC: C07K16/18 ,  C07K16/44 ,  G01N33/68

CPC classification number: C12Y201/01043 ,  C07K14/47 ,  C12N9/1007 ,  C12P21/06

Abstract: Provided herein are H1.0K180me2 antibodies, H1.0K180me2 proteins, and H1.0K180me2 peptides and methods of use for diagnostics and therapeutics. These H1.0K180me2 antibodies, H1.0K180me2 proteins, and H1.0K180me2 peptides may be used in the treatment of methylated H1.0-related diseases or conditions in an individual. These H1.0K180me2 antibodies, H1.0K180me2 proteins, and H1.0K180me2 peptides may also be used for the detection and quantification of a histone H1.0 protein or fragment thereof, comprising a dimethylated lysine at lysine residue 180 (H1.0K180me2); such compositions and methods are useful for detecting replicative senescence, DNA damage, genotoxic stress, radiation exposure, Alzheimer's disease, are useful for monitoring therapeutic regimens, patient stratification, drug screening, and may serve as a marker of biological aging in a system.

Abstract translation: 本文提供了H1.0K180me2抗体，H1.0K180me2蛋白和H1.0K180me2肽以及用于诊断和治疗的方法。 这些H1.0K180me2抗体，H1.0K180me2蛋白和H1.0K180me2肽可用于治疗个体中甲基化H1.0相关疾病或病症。 这些H1.0K180me2抗体，H1.0K180me2蛋白和H1.0K180me2肽也可用于检测和定量在赖氨酸残基180（H1.0K180me2）处包含二甲基化赖氨酸的组蛋白H1.0蛋白或其片段; 这种组合物和方法可用于检测复制性衰老，DNA损伤，基因毒性应激，辐射暴露，阿尔茨海默氏病，可用于监测治疗方案，患者分层，药物筛选，并可作为系统中生物老化的标志。