中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

22 records (took 0.024 seconds)

    PRODUCTION OF N-CONTAINING HETEROCYCLIC COMPOUND
    1.
    发明专利
    PRODUCTION OF N-CONTAINING HETEROCYCLIC COMPOUND 失效

    公开(公告)号：JP2000109483A

    公开(公告)日：2000-04-18

    申请号：JP32168999

    申请日：1999-11-11

    Applicant: AGENCY IND SCIENCE TECHN

    Inventor： TAGUCHI KAZUHIRO ,  MURAKAMI TEIICHI ,  TAKAHASHI TOSHIKAZU ,  UCHIMARU YUKO ,  HIRATANI KAZUHISA

    IPC: C07D487/04

    Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound having a bonding strength, selectivity and a bonding number equal to or more than those of natural nucleic acid bases without affected its bonding ability by chemical modifications and useful as a nucleic acid base-scavenger by hydrolyzing the chlorine atom in a specific heterocyclic compound. SOLUTION: This N-containing heterocyclic compound expressed by formula II (R is an alkyl), e.g. 2,6-dihydroxy-4,8-dioctadecyl-pyrimido[5,4-d]pyrimidine, etc.), is obtained by hydrolyzing the chlorine atom in a heterocyclic compound expressed by formula I, e.g. 2,6-dichloro-4,8-dioctadecyl-pyrimido[5,4- d]pyrimidine, etc.}, preferably in the presence of 18-crown-6 and potassium hydroxide. The compound of formula I is obtained by reacting 2,4,6,8- tetrachloropyrimido[5,4-d]pyrimidine with an amine such as octadecylamine or the like.

    MACROCYCLIC COBALT SCHIFF BASE COMPLEX, ITS INTERMEDIATE AND THEIR PRODUCTION
    2.
    发明专利
    MACROCYCLIC COBALT SCHIFF BASE COMPLEX, ITS INTERMEDIATE AND THEIR PRODUCTION 失效

    公开(公告)号：JPH0977786A

    公开(公告)日：1997-03-25

    申请号：JP26214695

    申请日：1995-09-14

    Applicant: AGENCY IND SCIENCE TECHN ,  NIPPON OXYGEN CO LTD

    Inventor： HIRATANI KAZUHISA ,  TAKAHASHI TOSHIKAZU ,  KASUGA KAZUYUKI ,  NAKATSUJI RIICHI ,  NAKAYAMA ICHIRO ,  OKAMOTO AYUMI ,  ITO NOBUYOSHI

    IPC: C07F15/06

    Abstract: PROBLEM TO BE SOLVED: To obtain the subject new complex having excellent solubility in an organic solvent and high oxygen adsorptivity and useful as an oxygen scavenger, etc., by reacting a specific bissalicylaldehyde derivative with tetramethylethylenediamine and reacting with a cobalt salt. SOLUTION: The new macrocyclic cobalt Schiff base complex is expressed by formula I[R1 is a (substituted)phenylene, a (substituted)pyridilene or a (substituted)alkylene; R2 to R6 are each H, a substituted)phenyl, a (substituted) alkyl, a halogen or a (substituted)alkoxy; Me is methyl] and has excellent solubility in an organic solvent and high oxygen adsorptivity, and is useful as an oxygen scavenger, etc. The new complex is obtained by reacting a bissalicylaldehyde derivative of formula II as a new compound with tetramethylethylenediamine to generate a macrocyclic Schiff base and reacting with a divalent cobalt salt such as cobalt acetate 4 hydrate.

    DIAMIDE DERIVATIVE OF ALPHA-AMINO ACID
    3.
    发明专利
    DIAMIDE DERIVATIVE OF ALPHA-AMINO ACID 失效

    公开(公告)号：JPH05163243A

    公开(公告)日：1993-06-29

    申请号：JP35334291

    申请日：1991-12-17

    Applicant: AGENCY IND SCIENCE TECHN

    Inventor： KASUGA KAZUYUKI ,  HIROSE TAKUJI ,  TAKAHASHI TOSHIKAZU ,  HIRATANI KAZUHISA

    IPC: B01D11/04 ,  C07D215/40 ,  C09K3/00

    Abstract: PURPOSE:To obtain a new diamide derivative of an alpha-amino acid useful as an ion transporting agent of selectively and continuously separating cupric ion from an aqueous solution in the presence of various ions, namely ionophore. CONSTITUTION:A diamide derivative of an a-amino acid of the formula (R1 and R2 are H, alkyl, arylalkyl or aryl) such as 8-(N-acetylphenylalanylamino) quinoline. The compound of the formula is obtained by amidating an amino group of an alpha-amino acid with a carboxylic acid anhydride or a carboxylic acid chloride, reacting the resulting substance with 1 equivalent acid halide to give a corresponding mixed acid anhydride and reacting the mixed acid anhydride with 1 equivalent 8-aminoquinoline. The new compound of the formula can be concentrated against ingredient of concentration by taking advantage of pH difference in both the aqueous phases.

    NUCLEIC ACID BASE-SCAVENGER CONSISTING OF N-CONTAINING HETEROCYCLIC COMPOUND
    4.
    发明专利
    NUCLEIC ACID BASE-SCAVENGER CONSISTING OF N-CONTAINING HETEROCYCLIC COMPOUND 失效

    公开(公告)号：JP2000109484A

    公开(公告)日：2000-04-18

    申请号：JP32169099

    申请日：1999-11-11

    Applicant: AGENCY IND SCIENCE TECHN

    Inventor： TAGUCHI KAZUHIRO ,  MURAKAMI TEIICHI ,  TAKAHASHI TOSHIKAZU ,  UCHIMARU YUKO ,  HIRATANI KAZUHISA

    IPC: C07D487/04 ,  G01N33/53 ,  G01N33/566

    Abstract: PROBLEM TO BE SOLVED: To obtain a nucleic acid base-scavenger having a bonding strength, selectivity and a bonding number equal to or more than those of natural nucleic acid bases without affected its bonding ability by chemical modifications and useful for separation and collection, purification etc., of nucleic acid-relating materials, etc., by bringing the scavenger to contain a specific N-containing heterocyclic compound. SOLUTION: This nucleic acid base-scavenger is brought to contain a heterocyclic compound expressed by formula I (R1 to R4 are each an alkylamino amino, OH or F, at least one of them is OH or F), e.g. 2,6-dihydroxy-4, 8-dioctadecyl- pyrimido[5,-4-d]pyrimidine, etc.}. The compound of formula I is obtained, e.g. by hydrolyzing a compound of formula II (R is an alkyl), e.g., 2,6-dichloro-4,8- dioctadecyl-pyrimido[5,4-d]pyrimidine, etc.}, preferably by using a solution containing 18-crown-6 and potassium hydroxide.

    PREPARATION OF ENAMINES
    5.
    发明专利
    PREPARATION OF ENAMINES 失效

    公开(公告)号：JPH11255714A

    公开(公告)日：1999-09-21

    申请号：JP5937298

    申请日：1998-03-11

    Applicant: AGENCY IND SCIENCE TECHN

    Inventor： UCHIMARU YUKO ,  TAGUCHI KAZUHIRO ,  MURAKAMI TEIICHI ,  TAKAHASHI TOSHIKAZU

    IPC: B01J31/20 ,  C07B61/00 ,  C07C209/60 ,  C07C211/45 ,  C07C211/48

    Abstract: PROBLEM TO BE SOLVED: To provide a method for rapidly and efficiently preparing enamines without forming a coprosuct by using cheap low toxic amines having N-H bond, and terminal acetylene compounds as raw materials and reacting the raw materials in the presence of a ruthenium complex. SOLUTION: (A) An amine (e.g. N-methylaniline) having at least one N-H bond and N atom having H, an alkyl or the like as a substituent, or forming a cyclic compound containing N atom, having one N-H bond and a substituent selected from an alkylene, aralkylene or the like is reacted with (B) a terminal acetylene compound (e.g. phenylacetylene) in the presence of (C) a ruthenium complex (preferably a complex containing an organic ligand, e.g. dodecacarbonyltriruthenium) to provide (D) the objective enamine [e.g. N-methyl- N-(α-styryl)aniline] in the method for preparing the enamines. As a result, the enamines useful as synthetic raw materials for fine chemicals are provided by one step.

    MACROCYCLIC COMPOUND AND ITS PRODUCTION
    7.
    发明专利
    MACROCYCLIC COMPOUND AND ITS PRODUCTION 失效

    公开(公告)号：JPH11158181A

    公开(公告)日：1999-06-15

    申请号：JP32288897

    申请日：1997-11-25

    Applicant: AGENCY IND SCIENCE TECHN

    Inventor： TAGUCHI KAZUHIRO ,  MURAKAMI TEIICHI ,  TAKAHASHI TOSHIKAZU ,  UCHIMARU YUKO ,  HIRATANI KAZUHISA ,  KASUGA KAZUYUKI

    IPC: C07D487/04 ,  C07D487/22

    Abstract: PROBLEM TO BE SOLVED: To produce a new compound useful for separating and purifying a substance in the same manner as that of cyclodextrin. SOLUTION: This compound is represented by formula I (X is a bivalent connecting group composed of a heteroatom; Y is a bivalent organic group). The compound represented by formula I is preferably obtained by dispersing a high-purity and fine powdery 4,6,8-tetrachloro-pyrimido[5,4-d]pyrimidine preferably purified by a sublimation method in an inert solvent such as chloroform and then slowly adding a chain compound represented by the formula OX-Y-XH (e.g. 1,10-diaminodecane) by small portions thereto in the presence of a base such as diisopropylethylamine.

    NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
    8.
    发明专利
    NITROGEN-CONTAINING HETEROCYCLIC COMPOUND 失效

    公开(公告)号：JPH1180159A

    公开(公告)日：1999-03-26

    申请号：JP28420397

    申请日：1997-09-09

    Applicant: AGENCY IND SCIENCE TECHN

    Inventor： TAGUCHI KAZUHIRO ,  MURAKAMI TEIICHI ,  TAKAHASHI TOSHIKAZU ,  UCHIMARU YUKO ,  HIRATANI KAZUHISA

    IPC: C07D487/04

    Abstract: PROBLEM TO BE SOLVED: To obtain a nitrogen-containing heterocyclic compound useful as a nucleic acid base scavenger. SOLUTION: This compound is shown by formula I (R to R are each amino, hydroxyl or F, wherein at least one of R to R is hydroxyl or F), e.g. 2,6- dichloro-4,8-dioctadecyl-pyrimide[5,4-d]pyrimidine. A compound shown by formula III, which is one of those shown by the formula I, is obtained by hydrolyzing chlorine at the 2- and 6-site contained in a compound shown by formula II (R is a hydrocarbon or H) with an aqueous solution containing KOH and 18-crown-6. The compound shown by the formula I is selectively bonded, via hydrogen bonding, to a heterocyclic compound having a partial structure of naturally occurring material related to nucleic acid or nucleic acid base, and can enhance separation/recovery or purification efficiency. It is highly selective, and useful as a material for stabilizing or quantitative analysis of nucleic acid base-related materials of similar properties.

Patent Agency Ranking