Microarray cleaning apparatus and microarray cleaning method
    1.
    发明专利
    Microarray cleaning apparatus and microarray cleaning method 审中-公开
    微波清洗装置和微波清洗方法

    公开(公告)号:JP2005351894A

    公开(公告)日:2005-12-22

    申请号:JP2005166612

    申请日:2005-06-07

    Inventor: SCHLEIFER ARTHUR

    Abstract: PROBLEM TO BE SOLVED: To reduce the amount of handling by the user and to improve the consistency of cleaning conditions. SOLUTION: An apparatus for bringing an array base material into contact with a fluid and a method for cleaning the array base material are disclosed. The apparatus includes a housing for demarcating a cleaning chamber, a fluid injection port communicating with the cleaning chamber to inject a fluid, a drain communicating with the cleaning chamber for draining the fluid, a gas injecting port fitted so as to turn the flow of gas to the surface of the array base material and a program controller operable in connection with the cleaning chamber. The program controller is operable so as to execute a cleaning protocol, including the automatic filling of the cleaning chamber with the fluid. In the method for cleaning the array base material, the array base material is arranged in the cleaning chamber, a first discharge and filling step is triggered, a second discharge and filling step is performed automatically, and a low-speed discharge step is performed automatically. COPYRIGHT: (C)2006,JPO&NCIPI

    Abstract translation: 要解决的问题:减少用户的处理量并提高清洁条件的一致性。 公开了一种用于使阵列基材与流体接触的装置和用于清洁阵列基材的方法。 该装置包括用于分隔清洁室的壳体,与清洁室连通以注射流体的流体注入口,与清洁室连通以排出流体的排水口,安装成使气流转动的气体注入口 到阵列基材的表面和与清洁室结合可操作的程序控制器。 程序控制器可操作以执行清洁协议,包括用流体自动填充清洁室。 在清扫阵列基材的方法中,阵列基材布置在清洁室中,触发第一次排出和填充步骤,自动执行第二次排放和填充步骤,并且自动执行低速放电步骤 。 版权所有(C)2006,JPO&NCIPI

    LIGHT DETECTION SYSTEM WITH WIDE DYNAMIC RANGE

    公开(公告)号:JP2000356594A

    公开(公告)日:2000-12-26

    申请号:JP2000136666

    申请日:2000-05-10

    Abstract: PROBLEM TO BE SOLVED: To expand a dynamic range without extending measurement or averaging time by selecting output from a discriminator/counter or an electric charge integrator or output from the linear combination of both of them based on the intensity of an output signal for recording or storing. SOLUTION: Incidence light 10 such as fluorescent light is detected by a photomultiplier(PMT) 12, and a detection signal is inputted to a discriminator/ counter 14 and an electric charge integrator 16. Then, the discriminator/counter 14 counts the number of photons regarding a signal that is less than a first selection level, covers a low-level signal within a specific range, and at the same time eliminates excessive noise. On the other hand, the integrator 16 integrates a signal within a strong range up to the saturation/breakdown limit exceeding the second selection level. A control circuit 18 reads the output of the discriminator/counter 14 and that of the integrator 16, stores both the results at a storage device 20, or selects either one of them based on the signal strength for storage.

    Automating process for cleaning array base material
    3.
    发明专利
    Automating process for cleaning array base material 审中-公开
    用于清洁阵列基材的自动化过程

    公开(公告)号:JP2005351895A

    公开(公告)日:2005-12-22

    申请号:JP2005166613

    申请日:2005-06-07

    Inventor: SCHLEIFER ARTHUR

    Abstract: PROBLEM TO BE SOLVED: To provide an automating process for cleaning an array base material. SOLUTION: In the array base material cleaning method, the array base material is brought into contact with a first cleaning solution and an automatic cleaning process is triggered. In the automatic cleaning process, (a) the array base material is separated from the first cleaning solution, (b) the array base material is brought into contact with a second cleaning solution, (c) the array base material is allowed to stand at a constant temperature in the second cleaning solution under a controlled condition, (d) the array base material is separated from a third cleaning solution, (e) the array base material is brought into contact with the third cleaning solution and (f) the array base material is separated from the third cleaning solution. COPYRIGHT: (C)2006,JPO&NCIPI

    Abstract translation: 要解决的问题:提供用于清洁阵列基材的自动化处理。 解决方案:在阵列基材清洁方法中,阵列基材与第一清洗溶液接触并触发自动清洗过程。 在自动清洗处理中,(a)将阵列基材与第一清洗液分离,(b)使阵列基材与第二清洗液接触,(c)使阵列基材静置在 在受控条件下在第二清洗溶液中保持恒定的温度,(d)阵列基材与第三清洗溶液分离,(e)使阵列基材与第三清洗溶液接触,(f)阵列 基材与第三清洗溶液分离。 版权所有(C)2006,JPO&NCIPI

    Energy variable type photoionization device and mass spectrometry
    4.
    发明专利
    Energy variable type photoionization device and mass spectrometry 有权
    能量可变型光电装置和大容量光谱

    公开(公告)号:JP2010045023A

    公开(公告)日:2010-02-25

    申请号:JP2009161604

    申请日:2009-07-08

    CPC classification number: H01J49/162

    Abstract: PROBLEM TO BE SOLVED: To provide a mass spectrometry using an energy variable type photoionization device (12) for ionizing and/or cleaving molecules. SOLUTION: This photoionization device cleaves molecular in a controlled mode by cutting off specific molecular binding, or selects an ionization photon wavelength from a range of a wavelength in which ionization photon energy can be adjusted in order to ionize a molecular without accompanying excessive fragmentation. The wavelength selection can be performed by selecting plasma formation gas (34) to be combined with the windowless emission of an ionization photon (38) from a plasma chamber. Also a mass spectrometry using the selected ionization photon wavelength is disclosed. COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 要解决的问题:提供使用能量可变型光电离装置(12)进行离子化和/或裂解分子的质谱法。 解决方案:该光电离装置通过切断特定的分子结合来切割受控模式的分子,或从可以调节电离光子能量的波长范围内选择电离光子波长,以便电离电子分子而不伴随过量 碎片。 波长选择可以通过选择等离子体形成气体(34)来进行,以与来自等离子体室的电离光子(38)的无窗口发射组合。 还公开了使用所选择的电离光子波长的质谱。 版权所有(C)2010,JPO&INPIT

    Device and method using fluid-transporting feature of differing dwell time
    5.
    发明专利
    Device and method using fluid-transporting feature of differing dwell time 审中-公开
    使用不同时间的流体传输特征的装置和方法

    公开(公告)号:JP2007139782A

    公开(公告)日:2007-06-07

    申请号:JP2006312863

    申请日:2006-11-20

    Abstract: PROBLEM TO BE SOLVED: To provide an improved fluid technology which is capable of using gradient liquid chromatography and reducing the amount of waste liquid, free of complications, has reproducibility, and shortens the delay time. SOLUTION: A fluidic device is provided with a plurality of fluid-transporting features, extending from a common inlet to a common outlet, and a means for effecting a fluid flow through the fluid-transporting features. Each feature has a differing fluid dwell time. The means for effecting a fluid flow cooperates with the fluid-transporting features, merges fluids from the fluid-transporting features, and produces an output stream from the common outlet. The output stream exhibits at least one desired characteristic generated as the result of the differing dwell times. It is thereby possible to generate a stream of a micro-volume flow rate and to obtain a smooth gradient in gradient liquid chromatography also. COPYRIGHT: (C)2007,JPO&INPIT

    Abstract translation: 要解决的问题:为了提供能够使用梯度液相色谱和减少没有并发症的废液的量的改进的流体技术,具有再现性并缩短延迟时间。 解决方案:流体装置设置有从公共入口延伸到公共出口的多个流体输送特征,以及用于实现流体流过流体输送特征的装置。 每个功能都具有不同的流体停留时间。 用于实现流体流动的装置与流体输送特征协作,合并来自流体输送特征的流体,并从公共出口产生输出流。 输出流表现出由于不同停留时间而产生的至少一个期望特性。 从而可以产生微量流量的流,并且也可以在梯度液相色谱中获得平滑的梯度。 版权所有(C)2007,JPO&INPIT

    Large dynamic range detection system

    公开(公告)号:GB2390900A

    公开(公告)日:2004-01-21

    申请号:GB0321705

    申请日:2000-05-08

    Abstract: A large dynamic range light detection system includes an asymmetric beam splitter for directing a larger fraction of incident light to one photomultiplier and a smaller fraction of the incident light to another photomultiplier. Preferably the light is split in to 90% and 10 % fractions and the photomultiplier receiving the larger fraction is operated in photon counting mode and the photomultiplier receiving the smaller fraction is operated in integrating mode. The beam splitter may be uncoated glass and fast modulators attenuate incident light on the photomultipliers.

    Sample atomization with reduced clogging for analytical instruments

    公开(公告)号:GB2530837A

    公开(公告)日:2016-04-06

    申请号:GB201509491

    申请日:2015-06-02

    Inventor: SCHLEIFER ARTHUR

    Abstract: An aerosol is produced by flowing a liquid sample through a gas-assisted nebulizer. The liquid exits from an outlet 248 into a coaxial flow of gas 244. The outlet includes a section that tapers 272 to a sharp edge outlet 212 that inhibits or prevents accumulation of precipitates or salts from the liquid, thereby reducing or eliminating clogging, which is particularly useful for a samples containing high concentrations of dissolved particles, i.e. less cleaning is required. The aerosol may be introduced into a plasma such that molecules are broken into atoms. The atomization may be followed by an analysis such as by optical emission spectrometry or mass spectrometry.

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