公开(公告)号：WO2016037973A1

公开(公告)日：2016-03-17

申请号：PCT/EP2015/070369

申请日：2015-09-07

Applicant: ALLNEX IP S.À.R.L.

Inventor： FLOOD, Lawrence

IPC: C07D251/70 ,  C07D251/54

CPC classification number: C07D251/24 ,  C07D251/18 ,  C07D251/54 ,  C07D251/70

Abstract: This invention relates to a process for the preparation of triazine carbamates by reacting a mixture of an aminotriazine A having at least two amino groups per molecule, an organic carbonate C, and a base B selected from the group consisting of alkoxides, and arylalkoxides of metals M, which may be alkali or earth alkali metals, and a solvent S which is a monohydric alcohol solvent R 2 OH or a mixture of solvents that comprises a monohydric alcohol R 2 OH, and a monohydric alcohol R 3 OH, or a mixture of solvents that comprises a monohydric alcohol R 2 OH with a further solvent selected from the group consisting of ether, alcohol, and hydrocarbon solvents, and adding to the products of the said reaction, an acid or a solution of an acid in a solvent.

Abstract translation: 本发明涉及一种通过使每分子具有至少两个氨基的氨基三嗪A与有机碳酸酯C和碱金属B的混合物的混合物制备三嗪的方法，该碱金属选自醇盐和金属的芳基烷氧基化物 M，其可以是碱金属或碱土金属，以及溶剂S，其是一元醇溶剂R2OH或包含一元醇R2OH和一元醇R3OH的溶剂混合物，或包含一元醇的溶剂混合物 R2OH与选自醚，醇和烃溶剂的另外的溶剂，并将所述反应的产物，酸或溶剂中的酸溶液加入。

公开(公告)号：EP2734506B1

公开(公告)日：2017-01-11

申请号：EP12738701.7

申请日：2012-07-19

Applicant: Allnex IP S.à.r.l.

Inventor： GUPTA, Ram ,  KOBYLANSKA, Irina ,  TREASURER, Urvee ,  FLOOD, Lawrence

IPC: C07D233/34 ,  A61K31/4166

CPC classification number: C07D243/04 ,  C07D233/34 ,  C07D239/10

公开(公告)号：EP2734507B1

公开(公告)日：2017-05-31

申请号：EP12743013.0

申请日：2012-07-19

Applicant: Allnex IP S.à.r.l.

Inventor： GUPTA, Ram ,  KOBYLANSKA, Irina ,  TREASURER, Urvee ,  FLOOD, Lawrence

IPC: C07D233/34 ,  C07D403/06

CPC classification number: C07D233/36 ,  C07D233/32 ,  C07D233/34

公开(公告)号：EP2734506A1

公开(公告)日：2014-05-28

申请号：EP12738701.7

申请日：2012-07-19

Applicant: Allnex IP S.à.r.l.

Inventor： GUPTA, Ram ,  KOBYLANSKA, Irina ,  TREASURER, Urvee ,  FLOOD, Lawrence

IPC: C07D233/34 ,  A61K31/4166

CPC classification number: C07D243/04 ,  C07D233/34 ,  C07D239/10

Abstract: The invention relates to a process for the synthesis of cyclic alkylene ureas comprising reacting in the presence of a basic catalyst, a difunctional amine A having two primary amino groups, and an aliphatic organic carbonate component C selected from the group consisting of dialkyl carbonates CD and of alkylene carbonates CA, wherein the ratio of the amount of substance Ji(-NH2) of primary amino groups -NH2 in the difunctional amine A to the sum M(C) of the amount of substance n(CD) of carbonate groups of a dialkyl carbonate CD and the amount of substance n(CA) of carbonate groups in an alkylene carbonate CA, is at least more than 2, and to the product obtained by this process.

公开(公告)号：EP2734507A1

公开(公告)日：2014-05-28

申请号：EP12743013.0

申请日：2012-07-19

Applicant: Allnex IP S.à.r.l.

Inventor： GUPTA, Ram ,  KOBYLANSKA, Irina ,  TREASURER, Urvee ,  FLOOD, Lawrence

IPC: C07D233/34 ,  C07D403/06 ,  A61K31/4166

CPC classification number: C07D233/36 ,  C07D233/32 ,  C07D233/34

Abstract: The invention relates to a process for the synthesis of N-substituted cyclic alkylene ureas by reacting a multifunctional aliphatic amine A having at least two amino groups which may be primary or secondary, at least one of which is a primary amino group, -NH
2 , and at least one of which is a secondary amino group, >NH, the other hydrogen group whereof having been substituted by a hydrocarbyl group which in turn may be substituted by a hydroxyl group, or an amino group, or a carboxyl group, or a ketone carbonyl group, or a hydrazide or hydrazone group, or a mercaptan group, and at least one further functional group selected from the group consisting of primary or secondary amino groups and hydroxyl groups, and an aliphatic organic carbonate component C selected from the group consisting of dialkyl carbonates CD and of alkylene carbonates CA.

公开(公告)号：EP3191460A1

公开(公告)日：2017-07-19

申请号：EP15757306.4

申请日：2015-09-07

Applicant: Allnex IP S.à.r.l.

Inventor： FLOOD, Lawrence

IPC: C07D251/70 ,  C07D251/54

Abstract: This invention relates to a process for the preparation of triazine carbamates by reacting a mixture of an aminotriazine A having at least two amino groups per molecule, an organic carbonate C, and a base B selected from the group consisting of alkoxides, and arylalkoxides of metals M, which may be alkali or earth alkali metals, and a solvent S which is a monohydric alcohol solvent R 2 OH or a mixture of solvents that comprises a monohydric alcohol R 2 OH, and a monohydric alcohol R 3 OH, or a mixture of solvents that comprises a monohydric alcohol R 2 OH with a further solvent selected from the group consisting of ether, alcohol, and hydrocarbon solvents, and adding to the products of the said reaction, an acid or a solution of an acid in a solvent.

Abstract translation: 本发明涉及一种通过每分子具有至少两个氨基的氨基三嗪A，有机碳酸酯C和选自醇盐和碱金属的芳基烷氧化物的碱B的混合物反应制备三嗪氨基甲酸酯的方法 M，其可以是碱金属或碱土金属;以及溶剂S，其是一元醇溶剂R 2 OH或包含一元醇R 2 OH和一元醇R 3 OH的溶剂的混合物，或者是 包含一元醇R 2 OH与选自醚，醇和烃溶剂的另外的溶剂的溶剂，并向所述反应的产物中加入酸或酸在溶剂中的溶液。