公开(公告)号：WO0214489A3

公开(公告)日：2002-07-25

申请号：PCT/US0125054

申请日：2001-08-10

Applicant: AMGEN INC ,  PASZTY CHRISTOPHER J ,  GONG JIANHUA ,  DAUGHERTY BETSY ,  ROGERS NORMA

Inventor： PASZTY CHRISTOPHER J ,  GONG JIANHUA ,  DAUGHERTY BETSY ,  ROGERS NORMA

IPC: A01K67/027 ,  A61K38/00 ,  A61K45/00 ,  A61P29/00 ,  A61P31/04 ,  A61P35/02 ,  A61P37/00 ,  C07K14/705 ,  C07K14/72 ,  C07K16/00 ,  C07K16/28 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  G01N33/53 ,  G01N33/566 ,  C12N15/12 ,  A61K38/17 ,  A61K48/00 ,  C12N15/62 ,  C12N15/86 ,  C12Q1/68 ,  G01N33/577 ,  G01N33/68

CPC classification number: C07K14/723 ,  A01K2217/05 ,  A61K38/00

Abstract: The present invention provides Leucine-Rich Repeat-Containing G-Protein Coupled Receptor-8 (LGR8) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing LGR8 polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with LGR8 polypeptides.

Abstract translation: 本发明提供了含有亮氨酸的重复含有G蛋白偶联受体-8（LGR8）多肽和编码该多肽的核酸分子。 本发明还提供选择性结合剂，载体，宿主细胞和用于产生LGR8多肽的方法。 本发明还提供用于诊断，治疗，改善和/或预防与LGR8多肽相关的疾病，病症和病症的药物组合物和方法。

公开(公告)号：CA2438107A1

公开(公告)日：2002-10-24

申请号：CA2438107

申请日：2002-02-14

Applicant: AMGEN INC

Inventor： ELLIOTT STEVEN G ,  BUSSE LEIGH ANNE ,  ROGERS NORMA

IPC: A01K67/027 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/395 ,  A61K48/00 ,  A61P1/16 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P15/08 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07K14/705 ,  C07K16/28 ,  C12M1/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  A01K67/00 ,  C12Q1/00 ,  C12Q1/02 ,  C12N5/12 ,  A61K38/17 ,  A61L27/38 ,  G01N33/566 ,  C12N15/86

Abstract: The present invention provides G-Protein Coupled Receptor (GPCR) polypeptide s and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing GPC R polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with GPCR polypeptides.

公开(公告)号：WO0214489A9

公开(公告)日：2003-09-25

申请号：PCT/US0125054

申请日：2001-08-10

Applicant: AMGEN INC ,  PASZTY CHRISTOPHER J ,  GONG JIANHUA ,  DAUGHERTY BETSY ,  ROGERS NORMA

Inventor： PASZTY CHRISTOPHER J ,  GONG JIANHUA ,  DAUGHERTY BETSY ,  ROGERS NORMA

IPC: A01K67/027 ,  A61K38/00 ,  A61K45/00 ,  A61P29/00 ,  A61P31/04 ,  A61P35/02 ,  A61P37/00 ,  C07K14/705 ,  C07K14/72 ,  C07K16/00 ,  C07K16/28 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  G01N33/53 ,  G01N33/566 ,  C12N15/12 ,  A61K38/17 ,  A61K48/00 ,  C12N15/62 ,  C12N15/86 ,  C12Q1/68 ,  G01N33/577 ,  G01N33/68

CPC classification number: C07K14/723 ,  A01K2217/05 ,  A61K38/00

Abstract: The present invention provides Leucine-Rich Repeat-Containing G-Protein Coupled Receptor-8 (LGR8) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing LGR8 polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with LGR8 polypeptides.

Abstract translation: 本发明提供了含有亮氨酸的重复含有G蛋白偶联受体-8（LGR8）多肽和编码该多肽的核酸分子。 本发明还提供选择性结合剂，载体，宿主细胞和用于产生LGR8多肽的方法。 本发明还提供用于诊断，治疗，改善和/或预防与LGR8多肽相关的疾病，病症和病症的药物组合物和方法。

公开(公告)号：AU2002303091B2

公开(公告)日：2006-11-09

申请号：AU2002303091

申请日：2002-02-14

Applicant: AMGEN INC

Inventor： BUSSE LEIGH ANNE ,  ELLIOTT STEVEN G ,  ROGERS NORMA

IPC: A01K67/027 ,  C07K14/705 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/395 ,  A61K48/00 ,  A61P1/16 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P15/08 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07K16/28 ,  C12M1/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53

Abstract: The present invention provides G-Protein Coupled Receptor (GPCR) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing GPCR polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with GPCR polypeptides.

公开(公告)号：AU8325401A

公开(公告)日：2002-02-25

申请号：AU8325401

申请日：2001-08-10

Applicant: AMGEN INC

Inventor： PASZTY CHRISTOPHER J ,  GONG JIANHUA ,  DAUGHERTY BETSY ,  ROGERS NORMA

IPC: A01K67/027 ,  A61K38/00 ,  A61K45/00 ,  A61P29/00 ,  A61P31/04 ,  A61P35/02 ,  A61P37/00 ,  C07K14/705 ,  C07K14/72 ,  C07K16/00 ,  C07K16/28 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  G01N33/53 ,  G01N33/566 ,  C12N15/00

Abstract: The present invention provides Leucine-Rich Repeat-Containing G-Protein Coupled Receptor-8 (LGR8) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing LGR8 polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with LGR8 polypeptides.