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公开(公告)号：US20130230515A1
公开(公告)日：2013-09-05
申请号：US13682580
申请日：2012-11-20
Applicant: AMGEN INC.
Inventor： HQ HAN , HOSUNG MIN , THOMAS CHARLES BOONE
IPC: C07K16/22 , G01N33/567
CPC classification number: C07K16/22 , A61K38/00 , A61K2039/505 , C07K14/00 , C07K14/475 , C07K2317/21 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/35 , C12N2710/14143 , G01N33/567 , G01N33/74 , G01N2333/475
Abstract: The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such as a polymer or an Fc domain. The binding agents of the present invention produced increased lean muscle mass when administered to animals and decreased fat to muscle ratios. Therapeutic compositions containing the binding agents of the present invention are useful for treating muscle-wasting disorders and metabolic disorders including diabetes and obesity.
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公开(公告)号：PT3184546T
公开(公告)日：2019-09-16
申请号：PT16199717
申请日：2009-12-18
Applicant: AMGEN INC
Inventor： SHAW-FEN SYLVIA HU , HSIENG SEN LU , THOMAS CHARLES BOONE , DAVID W BRANKOW , CHADWICK T KING , COLIN V GEGG JR , LICHENG SHI , CEN XU
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公开(公告)号：MXPA02003126A
公开(公告)日：2002-09-30
申请号：MXPA02003126
申请日：2000-09-29
Applicant: AMGEN INC
Inventor： THOMAS CHARLES BOONE
IPC: C12N15/09 , A61K38/00 , A61K38/43 , A61K38/48 , A61K39/395 , A61P7/02 , C07K16/40 , C12N1/19 , C12N5/10 , C12N9/50 , C12N9/64 , C12N15/57 , C12P21/08 , C12R1/84
Abstract: Se describe un polipeptido de metaloproteinasa fibrinoliticamente activo denominado ("trombolitico de accion novedosa"), el cual es util para la lisis de coagulos sanguineos in vivo, asi como metodos y materiales para su produccion por expresion recombinante.
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公开(公告)号：HK1049351B
公开(公告)日：2005-07-29
申请号：HK03100667
申请日：2003-01-24
Applicant: AMGEN INC
Inventor： THOMAS CHARLES BOONE , HUIMIN LI , MICHAEL BENJAMIN MANN
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