公开(公告)号：WO2021202452A1

公开(公告)日：2021-10-07

申请号：PCT/US2021/024779

申请日：2021-03-30

Applicant: AMGEN INC.

Inventor： ACHMATOWICZ, Michael ,  CUI, Sheng ,  HWANG, Tsang-Lin ,  LANGILLE, Neil Fred ,  TOM, Janine K. ,  HUCKLE, James E. ,  STEC, Markian ,  WU, Tian ,  BROWN, Sean P.

IPC: C07D519/00 ,  A61P35/00 ,  A61K31/553

Abstract: Disclosed herein is an improved process for the synthesis of compound (A): (A), or a salt or solvate thereof via methylation of compound (B): (B), or a salt or solvate thereof, a crystalline hydrate of compound A, and pharmaceutical formulations comprising a crystalline hydrate of compound (A).