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公开(公告)号：WO2016154580A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/024308
申请日：2016-03-25
Applicant: AMGEN INC.
Inventor： CUI, Sheng , RANGANATHAN, Krishnakumar , CROCKETT, Richard , CHEN, Ying , SWIETLOW, Aleksander , CROSSLEY, Kevin , SHI, Yun , DECROOS, Karel , MONIOTTE, Etienne
CPC classification number: C07K1/026 , C07K1/18 , C07K5/081 , C07K5/1019 , C07K7/06
Abstract: The instant disclosure is directed to solution phase fragment coupling methods for preparing etelcalcetide and its pharmaceutically acceptable salts.
Abstract translation: 本公开涉及用于制备西替卡肽及其药学上可接受的盐的溶液相片段偶联方法。
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公开(公告)号：WO2015154031A1
公开(公告)日：2015-10-08
申请号：PCT/US2015/024347
申请日：2015-04-03
Applicant: AMGEN INC.
Inventor： BEZEMER, Jeroen , CHEN, Ying , CROCKETT, Richard , CROSSLEY, Kevin , CUI, Sheng , HUANG, Liang , JONES, Sian , LOWER, Asher , RANGANATHAN, Krishnakumar
CPC classification number: C07K7/06 , A61K38/00 , C07K1/1075
Abstract: A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided. AMG 416 is a synthetic, eight amino-acid selective peptide agonist of the calcium sensing receptor. It is being developed as an intravenous treatment of secondary hyperparathyroidism (SHPT) in hemodialysis patients with chronic kidney disease - mineral and bone disorder (CKD-MBD).
Abstract translation: 提供了制备AMG 416或其药学上可接受的盐的方法。 AMG 416是钙感应受体的合成的8个氨基酸选择性肽激动剂。 正在研制慢性肾脏疾病 - 矿物质和骨骼疾病（CKD-MBD）的血液透析患者的继发性甲状旁腺功能亢进症（SHPT）的静脉注射治疗。
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公开(公告)号：EP3274360B1
公开(公告)日：2020-05-06
申请号：EP16720588.9
申请日：2016-03-25
Applicant: Amgen Inc.
Inventor： CUI, Sheng , RANGANATHAN, Krishnakumar , CROCKETT, Richard , CHEN, Ying , SWIETLOW, Aleksander , CROSSLEY, Kevin , SHI, Yun , DECROOS, Karel , MONIOTTE, Etienne
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公开(公告)号：EP4219526A2
公开(公告)日：2023-08-02
申请号：EP23150870.6
申请日：2015-04-03
Applicant: AMGEN, INC.
Inventor： BEZEMER, Jeroen , CHEN, Ying , CROCKETT, Richard , CROSSLEY, Kevin , CUI, Sheng , HUANG, Liang , JONES, Sian , LOWER, Asher , RANGANATHAN, Krishnakumar
Abstract: A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided.
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Patent Agency Ranking
公开(公告)号：EP3126373A1
公开(公告)日：2017-02-08
申请号：EP15773570.5
申请日：2015-04-03
Applicant: Amgen Inc.
Inventor： BEZEMER, Jeroen , CHEN, Ying , CROCKETT, Richard , CROSSLEY, Kevin , CUI, Sheng , HUANG, Liang , JONES, Sian , LOWER, Asher , RANGANATHAN, Krishnakumar
Abstract: A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided.
Abstract translation: 提供了制备AMG 416或其药学上可接受的盐的方法。 AMG 416是钙感应受体的合成的8个氨基酸选择性肽激动剂。 正在研制慢性肾脏疾病 - 矿物质和骨骼疾病（CKD-MBD）的血液透析患者的继发性甲状旁腺功能亢进症（SHPT）的静脉注射治疗。
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公开(公告)号：EP3126373B1
公开(公告)日：2020-03-04
申请号：EP15773570.5
申请日：2015-04-03
Applicant: Amgen Inc.
Inventor： BEZEMER, Jeroen , CHEN, Ying , CROCKETT, Richard , CROSSLEY, Kevin , CUI, Sheng , HUANG, Liang , JONES, Sian , LOWER, Asher , RANGANATHAN, Krishnakumar
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公开(公告)号：EP3274360A1
公开(公告)日：2018-01-31
申请号：EP16720588.9
申请日：2016-03-25
Applicant: Amgen Inc.
Inventor： CUI, Sheng , RANGANATHAN, Krishnakumar , CROCKETT, Richard , CHEN, Ying , SWIETLOW, Aleksander , CROSSLEY, Kevin , SHI, Yun , DECROOS, Karel , MONIOTTE, Etienne
Abstract: The instant disclosure is directed to solution phase fragment coupling methods for preparing etelcalcetide and its pharmaceutically acceptable salts.
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公开(公告)号：EP4219526A3
公开(公告)日：2023-08-30
申请号：EP23150870.6
申请日：2015-04-03
Applicant: AMGEN, INC.
Inventor： BEZEMER, Jeroen , CHEN, Ying , CROCKETT, Richard , CROSSLEY, Kevin , CUI, Sheng , HUANG, Liang , JONES, Sian , LOWER, Asher , RANGANATHAN, Krishnakumar
Abstract: A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided.
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公开(公告)号：EP3708576A1
公开(公告)日：2020-09-16
申请号：EP20160369.3
申请日：2015-04-03
Applicant: Amgen Inc.
Inventor： BEZEMER, Jeroen , CHEN, Ying , CROCKETT, Richard , CROSSLEY, Kevin , CUI, Sheng , HUANG, Liang , JONES, Sian , LOWER, Asher , RANGANATHAN, Krishnakumar
Abstract: A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided.
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