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公开(公告)号：WO2018119183A2
公开(公告)日：2018-06-28
申请号：PCT/US2017/067801
申请日：2017-12-21
Applicant: AMGEN INC.
Inventor： LANMAN, Brian Alan , CEE, Victor J. , PICKRELL, Alexander J. , REED, Anthony B. , YANG, Kevin C. , KOPECKY, David John , WANG, Hui-Ling , LOPEZ, Patricia , ASHTON, Kate , BOOKER, Shon , TEGLEY, Christopher M.
IPC: C07D275/04 , C07D417/04 , C07D471/08 , C07D513/04 , C07D487/10 , C07D487/04 , C07D239/80 , C07D471/04 , C07D401/04 , C07D403/04 , A61K31/428 , A61K31/429 , A61K31/437 , A61K31/517 , A61K31/519 , A61K31/498 , A61K31/4985 , A61P35/00
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：WO2020050890A2
公开(公告)日：2020-03-12
申请号：PCT/US2019/036626
申请日：2019-06-11
Applicant: AMGEN INC.
Inventor： ALLEN, John Gordon , LANMAN, Brian Alan , CHEN, Jian , REED, Anthony B. , CEE, Victor J. , LIU, Longbin , LOPEZ, Patricia , WURZ, Ryan Paul , NGUYEN, Thomas T. , BOOKER, Shon , ALLEN, Jennifer Rebecca , CHU-MOYER, Margaret , AMEGADZIE, Albert , CHEN, Ning , GOODMAN, Clifford , LOW, Jonathan D. , MA, Vu Van , MINATTI, Ana Elena , NISHIMURA, Nobuko , PICKRELL, Alexander J. , WANG, Hui-Ling , SHIN, Youngsook , SIEGMUND, Aaron C. , YANG, Kevin C. , TAMAYO, Nuria A. , WALTON, Mary , XUE, Qiufen
Abstract: Provided herein are KRAS G12C inhibitors, such as [Insert Compound Here] composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：WO2012078777A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/063776
申请日：2011-12-07
Applicant: AMGEN INC. , WANG, Hui-Ling , BISWAS, Kaustav , CEE, Victor J. , CHAVEZ JR., Frank , HERBERICH, Bradley , JACKSON, Claire L.M. , LEE, Matthew , NIXEY, Thomas , PETTUS, Liping H. , REED, Anthony B. , RZASA, Robert M. , RUMFELT, Shannon , TASKER, Andrew , WU, Bin , WURZ, Ryan
Inventor： WANG, Hui-Ling , BISWAS, Kaustav , CEE, Victor J. , CHAVEZ JR., Frank , HERBERICH, Bradley , JACKSON, Claire L.M. , LEE, Matthew , NIXEY, Thomas , PETTUS, Liping H. , REED, Anthony B. , RZASA, Robert M. , RUMFELT, Shannon , TASKER, Andrew , WU, Bin , WURZ, Ryan
IPC: C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07D491/107 , A61K31/497 , A61K31/437 , A61K31/506 , A61K31/444 , A61K31/4709
CPC classification number: C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04
Abstract: The invention relates to bicyclic compounds of formula (1'), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
Abstract translation: 本发明涉及式（1'）的双环化合物及其盐。 在一些实施方案中，本发明涉及Pim-1和/或Pim-2和/或Pim-3蛋白激酶活性或酶功能的抑制剂或调节剂。 在另外的实施方案中，本发明涉及包含本文公开的化合物的药物组合物及其在预防和治疗Pim激酶相关病症和疾病，优选癌症中的用途。
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公开(公告)号：WO2008130508A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/004634
申请日：2008-04-09
Applicant: AMGEN INC. , ALLEN, Jennifer R. , BURLI, Roland , GOLDEN, Jennifer E. , MULLER, Kristine M. , REED, Anthony B.
Inventor： ALLEN, Jennifer R. , BURLI, Roland , GOLDEN, Jennifer E. , MULLER, Kristine M. , REED, Anthony B.
IPC: C07D213/16 , C07D309/04 , C07D333/10 , C07C15/24 , C07C235/04 , A61K31/44 , A61K31/381
CPC classification number: C07D213/16 , C07D213/56 , C07D309/04 , C07D309/06 , C07D333/10 , C07D333/24
Abstract: Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
Abstract translation: 式I化合物是HIF脯氨酰羟化酶的有用抑制剂。 式I的化合物具有以下结构：其中本文提供变量的定义。
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公开(公告)号：WO2019213516A1
公开(公告)日：2019-11-07
申请号：PCT/US2019/030593
申请日：2019-05-03
Applicant: AMGEN INC.
Inventor： ALLEN, John Gordon , ALLEN, Jennifer Rebecca , MINATTI, Ana Elena , XUE, Qiufen , WURZ, Ryan Paul , TEGLEY, Christopher M. , PICKRELL, Alexander J. , NGUYEN, Thomas T. , MA, Vu Van , LOPEZ, Patricia , LIU, Longbin , KOPECKY, David John , FROHN, Michael J. , CHEN, Ning , CHEN, Jian Jeffrey , SIEGMUND, Aaron C. , AMEGADZIE, Albert , TAMAYO, Nuria A. , BOOKER, Shon , GOODMAN, Clifford , WALTON, Mary , NISHIMURA, Nobuko , SHIN, Youngsook , LOW, Jonathan D. , CEE, Victor J. , REED, Anthony B. , WANG, Hui-Ling , LANMAN, Brian Alan
IPC: C07D403/04 , C07D403/14 , C07D471/04 , C07D487/04 , A61P35/00 , A61K31/519
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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Patent Agency Ranking
公开(公告)号：WO2019051291A1
公开(公告)日：2019-03-14
申请号：PCT/US2018/050044
申请日：2018-09-07
Applicant: AMGEN INC.
Inventor： LANMAN, Brian Alan , BOOKER, Shon , GOODMAN, Clifford , REED, Anthony B. , LOW, Jonathan D. , WANG, Hui-Ling , CHEN, Ning , MINATTI, Ana Elena , WURZ, Ryan , CEE, Victor J.
IPC: C07D471/04 , A61P35/00 , A61K31/519
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：WO2019036575A1
公开(公告)日：2019-02-21
申请号：PCT/US2018/046859
申请日：2018-08-17
Applicant: AMGEN INC.
Inventor： BROWN, Sean P. , LANMAN, Brian Alan , LI, Kexue , LI, Yunxiao , REED, Anthony B.
IPC: C07D498/08 , A61K31/553 , A61P35/00
Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.
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8.发明申请
公开(公告)号：WO2020050890A3
公开(公告)日：2020-03-12
申请号：PCT/US2019/036626
申请日：2019-06-11
Applicant: AMGEN INC.
Inventor： ALLEN, John Gordon , LANMAN, Brian Alan , CHEN, Jian , REED, Anthony B. , CEE, Victor J. , LIU, Longbin , LOPEZ, Patricia , WURZ, Ryan Paul , NGUYEN, Thomas T. , BOOKER, Shon , ALLEN, Jennifer Rebecca , CHU-MOYER, Margaret , AMEGADZIE, Albert , CHEN, Ning , GOODMAN, Clifford , LOW, Jonathan D. , MA, Vu Van , MINATTI, Ana Elena , NISHIMURA, Nobuko , PICKRELL, Alexander J. , WANG, Hui-Ling , SHIN, Youngsook , SIEGMUND, Aaron C. , YANG, Kevin C. , TAMAYO, Nuria A. , WALTON, Mary , XUE, Qiufen
IPC: C07D471/04 , C07D487/04 , A61K31/519 , A61K31/551 , A61P35/00 , A61K45/06
Abstract: Provided herein are KRAS G12C inhibitors, such as [Insert Compound Here] composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：WO2018217651A1
公开(公告)日：2018-11-29
申请号：PCT/US2018/033714
申请日：2018-05-21
Applicant: AMGEN INC.
Inventor： LANMAN, Brian Alan , CHEN, Jian , REED, Anthony B. , CEE, Victor J. , LIU, Longbin , KOPECKY, David John , LOPEZ, Patricia , WURZ, Ryan Paul , NGUYEN, Thomas T. , BOOKER, Shon , NISHIMURA, Nobuko , SHIN, Youngsook , TAMAYO, Nuria A. , ALLEN, John Gordon , ALLEN, Jennifer Rebecca
IPC: C07D471/04 , A61K31/519 , A61P35/00 , C07D475/00
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：WO2018119183A3
公开(公告)日：2018-06-28
申请号：PCT/US2017/067801
申请日：2017-12-21
Applicant: AMGEN INC.
Inventor： LANMAN, Brian Alan , CEE, Victor J. , PICKRELL, Alexander J. , REED, Anthony B. , YANG, Kevin C. , KOPECKY, David John , WANG, Hui-Ling , LOPEZ, Patricia , ASHTON, Kate , BOOKER, Shon , TEGLEY, Christopher M.
IPC: C07D275/04 , C07D417/04 , C07D471/08 , C07D513/04 , C07D487/10 , C07D487/04 , C07D239/80 , C07D471/04 , C07D401/04 , C07D403/04 , A61K31/428 , A61K31/429 , A61K31/437 , A61K31/517 , A61K31/519 , A61K31/498 , A61K31/4985 , A61P35/00
Abstract: Provided herein are benzisothiazol, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives and related compounds as KRAS G12C inhibitors for treating e.g. lung cancer, pancreatic cancer or colorectal cancer.
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