公开(公告)号：WO2023004075A1

公开(公告)日：2023-01-26

申请号：PCT/US2022/037928

申请日：2022-07-21

Applicant: AMGEN INC.

Inventor： WU, Tian ,  AGARWAL, Prashant ,  ROTHELI, Andreas R. ,  PARK, Hyunsoo ,  FROHN, Michael J.

IPC: C07D401/14 ,  A61P35/00 ,  A61K31/506

Abstract: Disclosed herein is a salt, a crystalline anhydrous form, a hydrate, a solvate, or a co-crystal of a free base compound 2-(6-azaspiro[2.5]octan-6-yl)-N-[2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl]-4-[(2-hydroxyethanesulfonyl)amino]benzamide (Compound A); method of preparation, pharmaceutical compositions, and method of treating a disease mediated by a motor protein kinesin family member 18A (KIF18A) inhibition, wherein said disease is a neoplastic disease, including a cancer or a tumor.

公开(公告)号：EP4373818A1

公开(公告)日：2024-05-29

申请号：EP22761662.0

申请日：2022-07-21

Applicant: AMGEN INC.

Inventor： WU, Tian ,  AGARWAL, Prashant ,  ROTHELI, Andreas R. ,  PARK, Hyunsoo ,  FROHN, Michael J.

IPC: C07D401/14 ,  A61P35/00 ,  A61K31/506

CPC classification number: C07D401/14 ,  A61P35/00