公开(公告)号：WO2022115400A1

公开(公告)日：2022-06-02

申请号：PCT/US2021/060447

申请日：2021-11-23

Applicant: AMGEN INC.

Inventor： BAUCOM, Kyle D. ,  CORBETT, Michael T. ,  CUI, Sheng ,  LANGILLE, Neil F. ,  ROTHELI, Andreas Rene ,  PROFETA, Roberto ,  SMITH, Austin G.

IPC: C07C67/14 ,  C07C67/293 ,  C07C69/16 ,  C07C69/78 ,  C07D513/10 ,  B01J31/28

Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound IA, wherein R1 is described herein. Compound IA can be useful in synthesizing compound A1, or a salt or solvate thereof, and compound A2, or a salt of solvate thereof.

公开(公告)号：WO2022051317A1

公开(公告)日：2022-03-10

申请号：PCT/US2021/048588

申请日：2021-09-01

Applicant: AMGEN INC.

Inventor： BEAVER, Matthew G. ,  DENNIS, Joseph ,  DORNAN, Peter K. ,  MENNEN, Steven ,  TEDROW, Jason S. ,  LANGILLE, Neil Fred ,  COHEN, Carolyn ,  ROTHELI, Andreas Rene

IPC: C07D519/00 ,  C07D513/10 ,  C07D267/12 ,  C07C205/59

Abstract: Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound Y that can be used to prepare them where the variable R1 is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof, compound A2, and salts and solvates thereof, and compound A3 and salts and solvates thereof. [INSERT COMPOUNDS HERE]

公开(公告)号：EP4251604A1

公开(公告)日：2023-10-04

申请号：EP21834994.2

申请日：2021-11-23

Applicant: Amgen Inc.

Inventor： BAUCOM, Kyle D. ,  CORBETT, Michael T. ,  CUI, Sheng ,  LANGILLE, Neil F. ,  ROTHELI, Andreas Rene ,  PROFETA, Roberto ,  SMITH, Austin G.

IPC: C07C67/14 ,  C07C67/293 ,  C07C69/16 ,  C07C69/78 ,  C07D513/10 ,  B01J31/28

公开(公告)号：EP4208467A1

公开(公告)日：2023-07-12

申请号：EP21778303.4

申请日：2021-09-01

Applicant: Amgen Inc.

Inventor： BEAVER, Matthew G. ,  DENNIS, Joseph ,  DORNAN, Peter K. ,  MENNEN, Steven ,  TEDROW, Jason S. ,  LANGILLE, Neil Fred ,  COHEN, Carolyn ,  ROTHELI, Andreas Rene

IPC: C07D519/00 ,  C07D513/10 ,  C07D267/12 ,  C07C205/59