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公开(公告)号：WO2023076318A1
公开(公告)日：2023-05-04
申请号：PCT/US2022/047790
申请日：2022-10-26
Applicant: AMGEN INC.
Inventor： KHODABANDEHLOU, Hamid , WANG, Tony, Y. , TULSYAN, Aditya , SCHORNER, Gregory, L.
Abstract: A method (500) for monitoring and/or controlling a pharmaceutical process includes obtaining (502) one-dimensional spectral data generated by a spectroscopy system (e.g., a Raman spectroscopy system), converting (508) the one-dimensional spectral data to a two-dimensional spectral data matrix, and applying the two-dimensional spectral data matrix to an input layer of a deep learning model (e.g., a convolutional neural network). The deep learning model predicts (410) a parameter (e.g., metabolite level) based on the two-dimensional spectral data matrix, e.g., in order to monitor and/or control a pharmaceutical process.
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公开(公告)号：WO2022072198A1
公开(公告)日：2022-04-07
申请号：PCT/US2021/051570
申请日：2021-09-22
Applicant: AMGEN INC.
Inventor： KHODABANDEHLOU, Hamid , WANG, Tony, Y. , TULSYAN, Aditya
Abstract: A method of controlling a cell culture process includes, for each time interval of one or more time intervals during the cell culture process, obtaining current values of one or more cell culture attributes associated with a cell culture, predicting one or more future values of a particular cell culture attribute associated with the cell culture, and controlling one or more physical inputs to the cell culture process. Predicting the future value(s) includes applying the current values of the cell culture attribute(s), and an earlier value of at least one of the cell culture attributes, as inputs to a data-driven predictive model using historical data. Controlling the physical input(s) includes applying the future value(s) as inputs to a model predictive controller.
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3.发明申请
公开(公告)号：WO2020086635A1
公开(公告)日：2020-04-30
申请号：PCT/US2019/057513
申请日：2019-10-23
Applicant: AMGEN INC.
Inventor： TULSYAN, Aditya
Abstract: A method for monitoring and/or controlling a biopharmaceutical process includes determining a query point associated with scanning of the process by a spectroscopy system (e.g., a Raman spectroscopy system), and querying an observation database containing observation data sets associated with past observations of biopharmaceutical processes. Each of the observation data sets includes spectral data and a corresponding actual analytical measurement. Querying the observation database includes selecting as training data, from among the observation data sets, those data sets that satisfy one or more relevancy criteria with respect to the query point. The method also includes using the selected training data to calibrate a local model specific to the biopharmaceutical process. The local model (e.g., a Gaussian process model) is trained to predict analytical measurements based on spectral data inputs. The method also includes using the local model to predict an analytical measurement of the biopharmaceutical process.
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Patent Agency Ranking
公开(公告)号：EP4423483A1
公开(公告)日：2024-09-04
申请号：EP22818515.3
申请日：2022-10-26
Applicant: Amgen Inc.
Inventor： KHODABANDEHLOU, Hamid , WANG, Tony, Y. , TULSYAN, Aditya , SCHORNER, Gregory, L.
CPC classification number: G01N21/65 , G01N2201/129620130101 , G01N21/359 , G01J3/44 , G01J3/28 , G06N3/0464 , G06N3/048 , G06N3/09
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公开(公告)号：EP4548161A1
公开(公告)日：2025-05-07
申请号：EP23748358.1
申请日：2023-06-29
Applicant: Amgen Inc.
Inventor： TULSYAN, Aditya
IPC: G05B13/04 , G05B17/02 , G05B19/418 , C12M1/36
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公开(公告)号：EP4482938A1
公开(公告)日：2025-01-01
申请号：EP23712661.0
申请日：2023-02-24
Applicant: Amgen Inc.
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公开(公告)号：EP4204538A1
公开(公告)日：2023-07-05
申请号：EP21806433.5
申请日：2021-09-22
Applicant: Amgen Inc.
Inventor： KHODABANDEHLOU, Hamid , WANG, Tony, Y. , TULSYAN, Aditya
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8.发明公开
公开(公告)号：EP3870957A1
公开(公告)日：2021-09-01
申请号：EP19848831.4
申请日：2019-10-23
Applicant: Amgen Inc.
Inventor： TULSYAN, Aditya
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