公开(公告)号：WO0147951A3

公开(公告)日：2002-04-25

申请号：PCT/CA0001581

申请日：2000-12-22

Applicant: STEWART DUNCAN JOHN ,  AN GO GEN INC

Inventor： STEWART DUNCAN JOHN

IPC: A61K38/00 ,  C07K14/515 ,  C07K14/52 ,  C12N5/10 ,  C12N15/12 ,  C12N15/62

CPC classification number: C07K14/515 ,  A61K38/00 ,  C07K14/52

Abstract: Angiopoietin analogs capable of binding to and activating TIE2 receptors by dimerization thereof, the angiopoietin analogs being proteinaceous molecules having at least 2 angiopoietin-like TIE2 binding domains.

公开(公告)号：CA2266805C

公开(公告)日：2015-04-28

申请号：CA2266805

申请日：1999-03-25

Applicant: AN GO GEN INC

Inventor： STEWART DUNCAN JOHN

IPC: A61K38/18 ,  A61K35/12 ,  A61K38/44 ,  A61K48/00 ,  A61P11/00 ,  C12N5/071 ,  C12N5/077

Abstract: Cell-based gene transfer is effected by administering transfected cells containing an expressible transgene into the pulmonary system of a patient, where the cells express and secrete expression products of the transgene directly into the pulmonary system. Also provided is the use of angiogenic factors in treatment of pulmonary hypertension.

公开(公告)号：CA2227425A1

公开(公告)日：1999-09-27

申请号：CA2227425

申请日：1998-03-27

Applicant: AN GO GEN INC

Inventor： STEWART DUNCAN JOHN

IPC: A61K35/12 ,  A61K38/18 ,  A61K38/19 ,  A61K38/44 ,  A61K48/00

Abstract: Cell-based gene transfer is effected by administering transfected cells containing an expressible transgene into the pulmonary system of a patient, where the cells express and secrete expression products of the transgene directly into the pulmonary system. Also provided is the use of angiogenic factors in treatment of pulmonary hypertension.

公开(公告)号：CA2241615A1

公开(公告)日：1998-12-26

申请号：CA2241615

申请日：1998-06-26

Applicant: STEWART DUNCAN JOHN ,  LANGER ANATOLY ,  AN GO GEN INC

Inventor： STEWART DUNCAN JOHN ,  LANGER ANATOLY

IPC: A61B17/00 ,  A61B17/22 ,  A61M25/00 ,  A61M25/092

Abstract: A catheter assembly especially adapted for injecting therapeutic liquids such as DNA solutions to a patient's myocardium comprises an elongated guiding catheter for insertion through a patient's artery to the vicinity of the myocardium, a reservoir for therapeutic liquid at the distal end of the guiding catheter, one or more injection needles protruding from the distal end of the guiding catheter and in fluid communication with the reservoir, the extent of needle protrusion being appropriate for penetration of but not passage through the myocardial wall, and operating means for delivering a predetermined quantity of therapeutic liquid from the reservoir through the needles.

公开(公告)号：AU2337801A

公开(公告)日：2001-07-09

申请号：AU2337801

申请日：2000-12-22

Applicant: AN GO GEN INC

Inventor： STEWART DUNCAN JOHN

IPC: A61K38/00 ,  C07K14/515 ,  C07K14/52 ,  C07K14/00

公开(公告)号：CA2266805A1

公开(公告)日：1999-09-27

申请号：CA2266805

申请日：1999-03-25

Applicant: AN-GO-GEN INC

Inventor： STEWART DUNCAN JOHN

IPC: A61K35/12 ,  A61K48/00 ,  C12N5/071 ,  C12N5/077 ,  A61K38/18 ,  A61K38/44

Abstract: Cell-based gene transfer is effected by administering transfected cells containing an expressible transgene into the pulmonary system of a patient, where the cells express and secrete expression products of the transgene directly into the pulmonary system. Also provided is the use of angiogenic factors in treatment of pulmonary hypertension.