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    COMPOUNDS OF '3-(5-SUSTITUTED OXY-2,4-DINITRO-PHENYL)-2-OXO-PROPIONIC ACID ESTER', PROCESS AND APPLICATIONS THEREOF
    1.
    发明申请
    COMPOUNDS OF '3-(5-SUSTITUTED OXY-2,4-DINITRO-PHENYL)-2-OXO-PROPIONIC ACID ESTER', PROCESS AND APPLICATIONS THEREOF 审中-公开
    “3-（5-巯基-2-丁基苯基）-2-氧 - 丙酸酯”的化合物，其工艺及应用

    公开(公告)号：WO2014195896A1

    公开(公告)日：2014-12-11

    申请号：PCT/IB2014/061980

    申请日：2014-06-05

    Applicant: ANTHEM BIOSCIENCES PVT. LTD.

    Inventor： GAVARA GOVINDA, Rajulu ,  SAMBASIVAM, Ganesh ,  PUTHIAPARAMPIL, Tom Thomas ,  CHANDRAPPA KORAMANGALA, Ravindra

    IPC: C07C205/12 ,  C07C205/56 ,  C07D471/04

    CPC classification number: C07D471/04 ,  C07C201/08 ,  C07C205/56 ,  C07C205/12

    Abstract: The present disclosure relates to compounds of Formula (I) and process of obtaining the same. Said compounds of Formula (I) is employed in the syntheses of pyrroloquinoline quinone (PQQ), 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid 2-allyl ester, 5-ethoxy-5-hydroxy-4-oxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, 5- hydroxy-6-(1,1,4-trioxo-1 lambda* 6*-1,2, 5 -thiadiazolidin-2-yl)-1H-indole-2-carboxylic acid and its pharmaceutically acceptable salts. Said syntheses of compounds via. compounds of Formula (I) as intermediates employ minimum number of steps resulting in a shorter process and has improved efficiency along with many other advantages.

    Abstract translation: 本公开涉及式（I）的化合物及其获得方法。 所述式（I）化合物用于合成吡咯并喹啉醌（PQQ），4,5-二氧代-4,5-二氢-1H-吡咯并[2,3-f]喹啉-2,7,9-三羧酸 酸2-烯丙酯，5-乙氧基-5-羟基-4-氧代-4,5-二氢-1H-吡咯并[2,3-f]喹啉-2,7,9-三羧酸，5-羟基-6 - （1,1,4-三氧杂-1λ* 6 * -1,2,5-噻二唑烷-2-基）-1H-吲哚-2-羧酸及其药学上可接受的盐。 所述合成化合物通过。 作为中间体的式（I）化合物使用最少数量的步骤，导致更短的工艺并且具有改善的效率以及许多其它优点。

    NOVEL EXPRESSION AND SECRETION VECTOR SYSTEMS FOR HETEROLOGOUS PROTEIN PRODUCTION IN ESCHERICHIA COLI
    4.
    发明公开
    NOVEL EXPRESSION AND SECRETION VECTOR SYSTEMS FOR HETEROLOGOUS PROTEIN PRODUCTION IN ESCHERICHIA COLI 审中-公开
    新型大肠杆菌异源蛋白产生的新型表达和分泌载体系统

    公开(公告)号：EP2694656A1

    公开(公告)日：2014-02-12

    申请号：EP12767888.6

    申请日：2012-04-08

    Applicant: Anthem Biosciences Pvt Ltd

    Inventor： NAIR, Ayyappan ,  SUKUMARAN, Sunil Kumar ,  SAMANT, Shalaka ,  GUPTA, Gunja ,  PICHAIMUTHU, Suthakarn ,  SAMBASIVAM, Ganesh

    IPC: C12N15/67 ,  C12N15/09 ,  C12N15/70 ,  C12N15/63

    CPC classification number: C12N15/70 ,  C07K2319/02 ,  C07K2319/034 ,  C07K2319/035 ,  C12N15/625 ,  C12P21/02

    Abstract: The present invention relates to a recombinant DNA expression/secretion system in E. coliwherein the said system combines the potential of signal peptide-based translocation of recombinant proteins to the periplasmic space of E. coli with membrane defective mutants of E. coli to further aid secretion into the extracellular space. The present invention further relates to the expression system which furthermore includes a helper plasmid to drive the expression of translocons to facilitate improved periplasmic secretion of the over-expressed recombinant protein. In addition, this system also facilitates efficient production of specific proteins of interest in E. coli.

    Abstract translation: 本发明涉及大肠杆菌中的重组DNA表达/分泌系统，其中所述系统将重组蛋白质的基于信号肽的易位与具有膜缺陷型大肠杆菌突变体的大肠杆菌周质空间的潜力结合以进一步辅助 分泌到细胞外空间。 本发明进一步涉及进一步包含辅助质粒以驱动转座子表达以促进过表达重组蛋白的周质分泌的表达系统。 此外，该系统还有助于在大肠杆菌中有效生产感兴趣的特定蛋白质。

    COMPOUNDS OF '3-(5-SUSTITUTED OXY-2,4-DINITRO-PHENYL)-2-OXO-PROPIONIC ACID ESTER', PROCESS AND APPLICATIONS THEREOF
    6.
    发明公开
    COMPOUNDS OF '3-(5-SUSTITUTED OXY-2,4-DINITRO-PHENYL)-2-OXO-PROPIONIC ACID ESTER', PROCESS AND APPLICATIONS THEREOF 有权
    作者“化合物3-（5-取代的氧-2,4-二硝基 - 苯基）-2-氧代 - 丙酸酯，方法和应用

    公开(公告)号：EP3004047A1

    公开(公告)日：2016-04-13

    申请号：EP14733718.2

    申请日：2014-06-05

    Applicant: Anthem Biosciences Pvt Ltd

    Inventor： GAVARA GOVINDA, Rajulu ,  SAMBASIVAM, Ganesh ,  PUTHIAPARAMPIL, Tom Thomas ,  CHANDRAPPA KORAMANGALA, Ravindra

    IPC: C07C205/12 ,  C07C205/56 ,  C07D471/04

    CPC classification number: C07D471/04 ,  C07C201/08 ,  C07C205/56 ,  C07C205/12

    Abstract: The present disclosure relates to compounds of Formula (I) and process of obtaining the same. Said compounds of Formula (I) is employed in the syntheses of pyrroloquinoline quinone (PQQ), 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid 2-allyl ester, 5-ethoxy-5-hydroxy-4-oxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, 5- hydroxy-6-(1,1,4-trioxo-1 lambda* 6*-1,2, 5 -thiadiazolidin-2-yl)-1H-indole-2-carboxylic acid and its pharmaceutically acceptable salts. Said syntheses of compounds via. compounds of Formula (I) as intermediates employ minimum number of steps resulting in a shorter process and has improved efficiency along with many other advantages.

    Abstract translation: 新化合物3（3-（5- substituiertem氧基-2,4-二硝基 - 苯基）-2-氧代 - 丙酸酯）的合成使吡咯喹啉醌（PQQ），并使用它用于制药目的进行说明。 更具体地，本公开涉及通过使用新的中间体：式1在较短的处理和PQQ的更高的产率得到的在有效的方法在合成PQQ。 独特的工艺，使用要么氢氧化钠和/或碳酸钠的PQQ化合物钠因此被示出。

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