公开(公告)号：US09233085B1

公开(公告)日：2016-01-12

申请号：US14318245

申请日：2014-06-27

Applicant: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

Inventor： Theodore J. Price ,  Gregory D. Dussor ,  Dipti Tillu ,  Bo Lian

IPC: A61K31/155 ,  A61K31/05 ,  A61K9/00

CPC classification number: A61K31/155 ,  A61K9/0014 ,  A61K31/05 ,  A61K2300/00

Abstract: A topical composition containing an adenosine monophosphate protein kinase (AMPK) activator and methods of administering the AMPK activator for treating acute pain or preventing the development of chronic pain in a subject. The AMPK activator is resveratrol. A second AMPK activator may also be used. The second AMPK activator is metformin. The topical composition may be administered as a gel, ointment, cream, lotion, suspension, liquid, or transdermal patch.

Abstract translation: 含有腺苷一磷酸蛋白激酶（AMPK）激活剂的局部组合物和施用AMPK活化剂治疗急性疼痛或预防受试者慢性疼痛发展的方法。 AMPK激活剂是白藜芦醇。 也可以使用第二AMPK活化剂。 第二种AMPK活化剂是二甲双胍。 局部组合物可以作为凝胶，软膏，乳膏，洗剂，悬浮液，液体或透皮贴剂施用。

公开(公告)号：US10016486B1

公开(公告)日：2018-07-10

申请号：US14956042

申请日：2015-12-01

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

Inventor： Dong-Chul Pyun ,  Theodore J. Price ,  Gregory D. Dussor ,  Dipti Tillu ,  Bo Lian

IPC: A61K31/05 ,  A61K31/155 ,  A61K31/4365 ,  A61K31/7056 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/616 ,  A61K38/22 ,  A61K38/02 ,  A61K38/20 ,  A61K38/18

CPC classification number: A61K38/2264 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/05 ,  A61K31/155 ,  A61K31/4365 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/616 ,  A61K31/7056 ,  A61K38/02 ,  A61K38/185 ,  A61K38/204

Abstract: Methods and compositions using a combination of adenosine monophosphate protein kinase (AMPK) activators for treating pain such as post-surgical pain or development of chronic pain. The two or more AMPK activators work synergistically and may be administered in individually sub-efficacious doses. The AMPK activators may have different mechanisms of AMPK activation. The AMPK activators may be administered systemically and/or topically in, for example, as a gel, ointment, cream, lotion, suspension, liquid, or transdermal patch.