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1.发明专利
公开(公告)号：JP2014111663A
公开(公告)日：2014-06-19
申请号：JP2014051319
申请日：2014-03-14
Applicant: Array Biopharma Inc , アレイ バイオファーマ、インコーポレイテッド
Inventor： STEVEN W ANDREWS , JULIA HAAS , JIANG YUTONG , ZHANG GAN
IPC: C07D487/04 , A61K31/5025 , A61K31/5377 , A61K31/541 , A61P1/02 , A61P11/06 , A61P15/12 , A61P17/04 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P25/00 , A61P25/04 , A61P29/00 , A61P33/02 , A61P35/00 , A61P35/04 , A61P43/00 , C07D519/00
CPC classification number: C07D487/04 , A61K31/5025 , A61K31/5377 , A61K31/541 , C07C51/412 , C07C53/18 , C07D471/04 , C07D519/00
Abstract: PROBLEM TO BE SOLVED: To provide a substituted imidazo[1,2B]pyridazine compound as a TRK kinase inhibitor.SOLUTION: A compound of a formula I, where R, R, R, R, X, Y and n have meanings described in the description, is an inhibitor of Trk kinase and is useful for treatment of diseases which can be treated by the Trk kinase inhibitor. There is also provided a pharmaceutical composition containing the compound, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable diluent or carrier. There is also provided a method for treatment of pain, cancer, inflammation, neurodegenerative diseases or Trypanosoma cruzi infection in mammalian including administering therapeutically effective amount of the compound or the pharmaceutically acceptable salt thereof to the mammalian.
Abstract translation: 要解决的问题：提供取代的咪唑并[1,2B]哒嗪化合物作为TRK激酶抑制剂。解决方案：式I化合物，其中R，R，R，R，X，Y和n具有如 该描述是Trk激酶的抑制剂，并且可用于治疗可由Trk激酶抑制剂治疗的疾病。 还提供含有该化合物，其药学上可接受的盐，药学上可接受的稀释剂或载体的药物组合物。 还提供了一种用于治疗哺乳动物疼痛，癌症，炎症，神经变性疾病或克氏锥虫感染的方法，包括向哺乳动物施用治疗有效量的化合物或其药学上可接受的盐。
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公开(公告)号：JP2019001819A
公开(公告)日：2019-01-10
申请号：JP2018172485
申请日：2018-09-14
Applicant: ARRAY BIOPHARMA INC
Inventor： ALLEN SHELLEY , STEVEN W ANDREWS , BLAKE JAMES F , KEVIN R CONDROSKI , JULIA HAAS , LILY HUANG , JIANG YUTONG , TIMOTHY KERCHER , GABRIELLE R KOLAKOWSKI , SEO JEONGBEOB
IPC: C07D401/14 , A61K31/4155 , A61K31/416 , A61K31/4162 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61P25/00 , A61P29/00 , A61P33/00 , A61P35/00 , A61P43/00 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04
Abstract: 【課題】疼痛、がん、炎症、神経変性疾患およびある特定の感染症の治療において有用なTrkAキナーゼの阻害剤の提供。【解決手段】式Iで表されるピロリジニル尿素およびピロリジニルチオ尿素化合物。[式中、Y−B部分およびNH−C(=X)−NH部分はトランス立体配置にある]【選択図】なし
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3.发明专利SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUND AS TRK KINASE INHIBITOR 有权取代的吡唑并[1,5-a]吡嗪化合物作为TRK激酶抑制剂
公开(公告)号：JP2014177494A
公开(公告)日：2014-09-25
申请号：JP2014134304
申请日：2014-06-30
Applicant: Array Biopharma Inc , アレイ バイオファーマ、インコーポレイテッド
Inventor： JULIA HAAS , STEVEN W ANDREWS , JIANG YUTONG , ZHANG GAN
IPC: C07D487/04 , A61K31/519 , A61P1/02 , A61P11/06 , A61P13/10 , A61P17/04 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P25/04 , A61P29/00 , A61P35/00 , A61P43/00
CPC classification number: C07D487/04 , A61K9/0053 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D519/00
Abstract: PROBLEM TO BE SOLVED: To provide a TRK kinase inhibitor.SOLUTION: A compound of the formula I is a Trk kinase inhibitor and useful for treatments for diseases which can be treated by Trk kinase inhibitors, and R, R, R, R, X, Y and n in the formula have meanings described in the specification. There is also provided a method for treating pain, cancer, inflammation, neurodegenerative disease or Trypanosoma cruzi infection in mammals including administering a therapeutically effective amount of the compound of the formula I according to any one of claims 1 to 32 or a pharmaceutically acceptable salt thereof to the mammals.
Abstract translation: 要解决的问题：提供TRK激酶抑制剂。解决方案：式I化合物是Trk激酶抑制剂，可用于治疗可由Trk激酶抑制剂治疗的疾病，R，R，R，R，X 式中的Y和n具有说明书中描述的含义。 还提供了一种用于治疗哺乳动物的疼痛，癌症，炎症，神经变性疾病或克氏锥虫感染的方法，包括给予治疗有效量的根据权利要求1至32中任一项所述的式I化合物或其药学上可接受的盐 到哺乳动物。
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公开(公告)号：BR112019019101A2
公开(公告)日：2020-04-22
申请号：BR112019019101
申请日：2018-03-16
Applicant: ARRAY BIOPHARMA INC
Inventor： GABRIELLE R KOLAKOWSKI , JAMES F BLAKE , JULIA HAAS , STEVEN W ANDREWS
IPC: A61K31/395 , G01N33/574
Abstract: a presente invenção refere-se a métodos para inibir uma ros1 cinase com os compostos da fórmula i: i e sais farmaceuticamente aceitáveis dos mesmos, em que o anel a, anel b, w, m, d, r2, r2a, r3, r3a, e z são como definidos aqui. os compostos e métodos fornecidos aqui são úteis no tratamento de câncer (por exemplo, cânceres associados a ros1 como definidos aqui).
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公开(公告)号：MX2019004205A
公开(公告)日：2019-08-21
申请号：MX2019004205
申请日：2017-10-10
Applicant: ARRAY BIOPHARMA INC
Inventor： JAMES F BLAKE , STEVEN W ANDREWS , JULIA HAAS , YUTONG JIANG , GABRIELLE R KOLAKOWSKI , DAVID A MORENO , BARBARA J BRANDHUBER , TONY P TANG , ANDREW T METCALF , SEAN ARONOW , ADAM COOK , ELIZABETH A MCFADDIN , MEGAN L MCKENNEY , OREN T MCNULTY , LI REN
IPC: A61K31/437 , A61P35/00 , C07D471/04
Abstract: Se proporciona en la presente compuestos de la fórmula I: (Ver formula) Y estereoisómeros y sales o solvatos farmacéuticamente aceptables de los mismos, en donde A, B, X1, X2, X3, X4, Anillo D y E tienen los significados dados en la memoria descriptiva. Que no inhibidores de quinasa RET y son útiles en el tratamiento y prevención de enfermedades que se pueden tratar con un inhibidor de quinasa RET, lo que incluye enfermedades y trastornos asociados a RET.
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Patent Agency Ranking
公开(公告)号：BR112013029201B1
公开(公告)日：2022-08-09
申请号：BR112013029201
申请日：2012-05-09
Applicant: ARRAY BIOPHARMA INC
Inventor： SHELLEY ALLEN , STEVEN W ANDREWS , JAMES F BLAKE , KEVIN R CONDROSKI , JULIA HAAS , LILY HUANG , YUTONG JIANG , TIMOTHY KERCHER , GABRIELLE R KOLAKOWSKI , JEONGBEOB SEO
IPC: C07D401/14 , A61K31/4155 , A61K31/4162 , A61K31/4178 , A61K31/4192 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04
Abstract: COMPOSTOS DE PIRROLIDINIL UREIA E PIRROLIDINIL TIOUREIA, SEU PROCESSO DE PREPARAÇÃO, SEU USO E COMPOSIÇÕES FARMACÊUTICAS. Compostos de Fórmula I: ou estereoisômeros, tautômeros ou sais farmaceuticamente aceitáveis, ou solvatos ou profármacos dos mesmos, onde R1, R2, Ra, Rb, Rc, Rd, X, Y, B, e Anel C são como definidos aqui e em que a porção Y-B e a porção NH-C(=X)-NH estão na configuração trans, são inibidores de TrkA quinase e são úteis no tratamento de doenças as quais podem ser tratadas com um inibidor de TrkA quinase, tal como dor, câncer, inflamação, doenças neurodegenerativas e certas doenças infecciosas.
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公开(公告)号：MX2019010988A
公开(公告)日：2020-02-05
申请号：MX2019010988
申请日：2018-03-16
Applicant: ARRAY BIOPHARMA INC
Inventor： JAMES F BLAKE , STEVEN W ANDREWS , JULIA HAAS , GABRIELLE R KOLAKOWSKI
IPC: A61K31/395 , G01N33/574
Abstract: Métodos para inhibir una quinasa ROS1 con compuestos de la Fórmula I: y sales aceptables desde el punto de vista farmacéutico de estos, en donde el anillo A, el anillo B, W, m, D, R2, R2a, Ra, R3a y Z son como se definen en la presente. Los compuestos y métodos proporcionados en la presente son útiles en el tratamiento contra el cáncer (por ejemplo, tipos de cáncer asociados a ROS1 como se definen en la presente).
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公开(公告)号：MX2018014116A
公开(公告)日：2019-12-11
申请号：MX2018014116
申请日：2017-05-18
Applicant: ARRAY BIOPHARMA INC
Inventor： MARK REYNOLDS , STEVEN W ANDREWS , JULIA HAAS , YUTONG JIANG , DERRICK JUENGST , CHARLES TODD EARY , STACEY SPENCER , BRUNO HACHE
IPC: C07D487/04 , A61K31/5025 , A61P35/00
Abstract: La presente invención se refiere a un proceso para preparar un compuesto de Fórmula I (ver Fórmula) o una sal del mismo, como se describe en la presente.
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公开(公告)号：PT3154959T
公开(公告)日：2019-09-24
申请号：PT15726455
申请日：2015-05-14
Applicant: ARRAY BIOPHARMA INC
Inventor： SHELLEY ALLEN , STEVEN W ANDREWS , BRIAN BAER , ZACKARY CRANE , WEIDONG LIU , DANIEL JOHN WATSON
IPC: A61K45/06 , A61K9/00 , A61K31/506 , C07D207/16 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14
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公开(公告)号：MX2019004204A
公开(公告)日：2019-08-21
申请号：MX2019004204
申请日：2017-10-10
Applicant: ARRAY BIOPHARMA INC
Inventor： JAMES F BLAKE , STEVEN W ANDREWS , JULIA HAAS , YUTONG JIANG , GABRIELLE R KOLAKOWSKI , DAVID A MORENO , BARBARA J BRANDHUBER , TONY P TANG , ANDREW T METCALF , SEAN ARONOW , JAMES COLLIER , ADAM COOK , ELIZABETH A MCFADDIN , MEGAN L MCKENNEY , OREN T MCNULTY , GINELLE A RAMANN , LI REN , SHANE M WALLS
IPC: A61P35/00 , A61K31/437 , C07D471/04
Abstract: Se proporciona en la presente compuestos de la Fórmula 1: (Ver formula) o sales o solvatos farmacéuticamente aceptables de los mismos, en donde A. 6, X', X2, )0, X*, Anillo D, E. Re, 122, n y m tienen los significados dados en la memoria descriptiva, que son inhibidores de quinasa RET y son útiles en el tratamiento y prevención de enfermedades que se pueden tratara con un inhibidor de quinasa RET, lo que incluye enfermedades y trastornos asociados con RET.
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