公开(公告)号：US20030181725A1

公开(公告)日：2003-09-25

申请号：US10322778

申请日：2002-12-19

Applicant: ASAHI GLASS COMPANY LTD.

Inventor： Shu-zhong Wang ,  Takashi Okazoe ,  Yasushi Matsumura

IPC: C07D47/02

CPC classification number: C07D405/12

Abstract: A method of producing amorphous paroxetine hydrochloride, which comprises converting paroxetine or its lower alkanoic acid salt into paroxetine hydrochloride and then spray drying a solution of the hydrochloride.

Abstract translation: 一种生产无定形帕罗西汀盐酸盐的方法，其包括将帕罗西汀或其低级链烷酸盐转化为盐酸帕罗西汀，然后喷雾干燥盐酸盐溶液。

公开(公告)号：US20020198387A1

公开(公告)日：2002-12-26

申请号：US10157045

申请日：2002-05-30

Applicant: ASAHI GLASS COMPANY LTD.

Inventor： Shu-zhong Wang ,  Yasushi Matsumura

IPC: C07D45/02

CPC classification number: C07D405/12

Abstract: A process for producing a paroxetine represented by the following formula (4), which comprises reacting an N-alkylpiperidine represented by the following general formula (1) with a haloformic acid ester represented by the general formula (2) to prepare an alkoxycarbonylpiperidine represented by the general formula (3), and hydrolyzing the alkoxycarbonylpiperidine under alkaline conditions: 1 wherein each of R1 and R2 is a lower alkyl group, a lower cycloalkyl group, an aralkyl group or CmF2mnull1 (wherein m is an integer of from 1 to 6), and X is a halogen atom.

Abstract translation: 一种由下述通式（4）表示的帕罗西汀生产方法，其特征在于：将下述通式（1）表示的N-烷基哌啶与通式（2）表示的卤代甲酸酯反应，制备由 通式（3），在碱性条件下水解烷氧基羰基哌啶：其中R1和R2分别为低级烷基，低级环烷基，芳烷基或CmF2m + 1（其中m为1〜6的整数） ），X为卤素原子。