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公开(公告)号：WO0183007A2
公开(公告)日：2001-11-08
申请号：PCT/US0114181
申请日：2001-05-03
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： STRUYS MICHEL , DE SMET TOM , VERSICHELEN LINDA
CPC classification number: A61M5/172
Abstract: A system and method for controlling the administration of medication to a patient utilizes adaptive feedback to achieve and maintain a target effect in said patient. A sensor package having one or more sensors is used to sense an attribute of the patient and to provide a parameter indicating the attribute being sensed. A medication delivery controller accepts one or more parameters from the sensor package and uses these parameters to determine the effect of a medication on a patient and the concentration level of medication that will achieve a desired effect. The medication delivery controller controls the medication delivery unit to deliver the medication at a rate determined to achieve said target concentration level of said medication in said patient. If the patient's response to a given medication changes as a result of external stimuli, the medication delivery controller can detect this change and determine a new concentration level of medication which will achieve the desired effect. The medication delivery controller can steer the medication delivery unit to administer an amount of medication to reach this new concentration level.
Abstract translation: 用于控制向患者施用药物的系统和方法利用自适应反馈来实现和维持所述患者的目标效果。 使用具有一个或多个传感器的传感器包来感测患者的属性并提供指示被感测的属性的参数。 药物输送控制器从传感器封装接收一个或多个参数，并使用这些参数来确定药物对患者的影响以及将达到期望效果的药物浓度水平。 药物输送控制器控制药物输送单元以确定达到所述患者中所述药物的所述目标浓度水平的速率递送药物。 如果患者对给定药物的反应由于外部刺激而改变，则药物输送控制器可以检测该变化并确定将达到期望效果的新的药物浓度水平。 药物输送控制器可以引导药物输送单元来施用一定量的药物以达到该新的浓度水平。
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公开(公告)号：DE60121749D1
公开(公告)日：2006-09-07
申请号：DE60121749
申请日：2001-05-03
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： STRUYS MICHEL , DE SMET TOM , VERSICHELEN LINDA
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公开(公告)号：CA2409366A1
公开(公告)日：2001-11-08
申请号：CA2409366
申请日：2001-05-03
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： STRUYS MICHEL , VERSICHELEN LINDA , DE SMET TOM
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公开(公告)号：CA2554407C
公开(公告)日：2015-11-24
申请号：CA2554407
申请日：2005-01-27
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： STRUYS MICHEL MRF , DE SMET TOM , SHAFER STEVEN L
Abstract: The present invention provides a system and method for determining and maintaining a concentration level of medication in a patient sufficient to achieve and maintain a desired effect on that patient. Generally speaking, in accordance with one embodiment of the invention, a medication delivery controller uses a patient response profile to determine a concentration of medication in the patient that will achieve the desired effect on the patient. The patient response profile is a graphical, tabular or analytical expression of the relationship between the concentration of a medication and the effect of the medication at the specific concentration. Using this information, the medication delivery controller provides instructions to a medication delivery unit such as, for example, an infusion pump or inhalation device, to deliver the medication to the patient at a rate that will achieve the desired concentration level of the medication in the patient.
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Patent Agency Ranking
公开(公告)号：ES2267767T3
公开(公告)日：2007-03-16
申请号：ES01932895
申请日：2001-05-03
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： STRUYS MICHEL , DE SMET TOM , VERSICHELEN LINDA
Abstract: Un sistema para controlar la administración de medicamento a un paciente para conseguir y mantener un efecto objetivo en dicho paciente, comprendiendo el sistema: un conjunto (104) de sensores con uno o más sensores (608, 610, 612), estando configurados dichos sensores (608, 610, 612) para detectar una característica de dicho paciente (116) y para proporcionar un parámetro que indica la característica que se está detectando; una unidad (112) de suministro de medicamento configurada para administrar dicho medicamento a dicho paciente (116) para conseguir una concentración de dicho medicamento en dicho paciente (116); y un controlador (108) de suministro de medicamento con una entrada acoplada a dicho conjunto (104) de sensores y una salida acoplada a dicha unidad (112) de suministro de medicamento, estando configurado dicho controlador (108) de suministro de medicamento para aceptar dichos uno o más parámetros del conjunto (104) de sensores, caracterizado porque el controlador de suministrode medicamento está configurado para calcular un perfil de respuesta de un paciente individual para determinar un nivel de concentración objetivo de dicho medicamento para conseguir dicho efecto objetivo y para controlar dicha unidad (112) de suministro de medicamento para suministrar dicho medicamento a un ritmo determinado para conseguir dicho nivel de concentración objetivo de dicho medicamento en dicho paciente (116) en el que dicho perfil de respuesta del paciente individual define la respuesta individualizada del paciente (116) a dicho medicamento, siendo dicho perfil individual del paciente adaptable para adaptarse a las condiciones cambiantes del paciente.
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公开(公告)号：AT333911T
公开(公告)日：2006-08-15
申请号：AT01932895
申请日：2001-05-03
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： STRUYS MICHEL , DE SMET TOM , VERSICHELEN LINDA
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公开(公告)号：CA2409366C
公开(公告)日：2008-08-26
申请号：CA2409366
申请日：2001-05-03
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： STRUYS MICHEL , DE SMET TOM , VERSICHELEN LINDA
Abstract: A system and method for controlling the administration of medication to a patient utilizes adaptive feedback to achieve and maintain a target effect in said patient. A sensor package having one or more sensors is used to sense an attribute of the patient and to provide a parameter indicating the attribute being sensed. A medication delivery controller accepts one or more parameters from the sensor package and uses these parameters to determine the effect of a medication on a patient and the concentration level of medication that will achieve a desired effect. The medication delivery controller controls the medication delivery unit to deliver the medication at a rate determined to achieve said target concentration level of said medication in said patient. If the patient's response to a given medication changes as a result of external stimuli, the medication delivery controller can detect this change and determine a new concentration level of medication which will achieve the desired effect. The medication delivery controller can steer the medication delivery unit to administer an amount of medication to reach this new concentration level.
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公开(公告)号：DE60121749T2
公开(公告)日：2007-08-02
申请号：DE60121749
申请日：2001-05-03
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： STRUYS MICHEL , DE SMET TOM , VERSICHELEN LINDA
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公开(公告)号：CA2554407A1
公开(公告)日：2005-08-11
申请号：CA2554407
申请日：2005-01-27
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： DE SMET TOM , SHAFER STEVEN L , STRUYS MICHEL MRF
Abstract: The present invention provides a system and method for determining and maintaining a concentration level of medication in a patient sufficient to achieve and maintain a desired effect on that patient. Generally speaking, i n accordance with one embodiment of the invention, a medication delivery controller uses a patient response profile to determine a concentration of medication in the patient that will achieve the desired effect on the patien t. The patient response profile is a graphical, tabular or analytical expressio n of the relationship between the concentration of a medication and the effect of the medication at the specific concentration. Using this information, the medication delivery controller provides instructions to a medication deliver y unit such as, for example, an infusion pump or inhalation device, to deliver the medication to the patient at a rate that will achieve the desired concentration level of the medication in the patient.
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