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1.发明专利
公开(公告)号：JP2009080119A
公开(公告)日：2009-04-16
申请号：JP2008261171
申请日：2008-10-08
Applicant: Aurora Biosciences Corp , オーロラ バイオサイエンシズ コーポレーション
Inventor： PHAM ANDREW A , COASSIN PETER J , HAROOTUNIAN ALEC TATE , MENDLEIN JOHN D , TSIEN ROGER Y
IPC: G01N21/03 , G01N21/64 , B01L3/00 , B01L9/00 , C08G61/08 , C40B60/14 , G01N21/15 , G01N33/483 , G01N33/52 , G01N35/02
CPC classification number: B01L3/5085 , B01J2219/00317 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01L2200/12 , B01L2300/0829 , B01L2300/12 , C40B60/14
Abstract: PROBLEM TO BE SOLVED: To provide multi-well plates and platforms that comprise a layer having low fluorescence and high transmittance. SOLUTION: In the multi-well plates, a layer having cycloolefin copolymer, low fluorescence and high transmittance is heat-welded to a polymer platform, and the layer generates fluorescence of 400-200% or less comparing with fused silica of a thickness of 150 μm in exciting wavelength of 300-400 nm and light emission wavelength of 300-800 nm. The platform is especially appropriate for fluorescence measurement. COPYRIGHT: (C)2009,JPO&INPIT
Abstract translation: 要解决的问题：提供包括具有低荧光和高透射率的层的多孔板和平台。 解决方案：在多孔板中，将具有环烯烃共聚物的层，低荧光和高透射率的层热焊接到聚合物平台，并且该层与熔融石英相比产生400-200％以下的荧光 300-400nm的激发波长的厚度为150μm，光发射波长为300-800nm。 该平台特别适用于荧光测量。 版权所有（C）2009，JPO＆INPIT
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公开(公告)号：WO0004366A9
公开(公告)日：2000-06-02
申请号：PCT/US9916170
申请日：1999-07-16
Applicant: AURORA BIOSCIENCES CORP
Inventor： TSIEN ROGER Y , COASSIN PETER J , PHAM ANDREW A , HAROOTUNIAN ALEC TATE , VUONG MINH
IPC: G01N21/64 , G01N1/00 , G01N21/03 , G01N21/25 , G01N35/02 , G01N37/00 , G02B6/04 , G01N1/10 , G01N21/29 , G01N21/47
CPC classification number: G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6478 , G01N2021/6484 , G01N2201/0639
Abstract: The invention provides for a detector assembly, fiber assembly (204) and screening system for optical measurements. The invention includes a method of simultaneously measuring at least two optical properties of emitted light from at least one sample in a plurality of addressable wells (206) of a multiwell plate. The method including: aligning the wells of the plate to a plurality of ball lenses (205), directing electromagnetic radiation from an appropriate light source (201) coaxially through the symmetry axis of each ball lens, and detecting emitted light focused by the ball lenses from the sample.
Abstract translation: 本发明提供了用于光学测量的检测器组件，光纤组件（204）和筛选系统。 本发明包括同时测量来自多孔板的多个可寻址孔（206）中的至少一个样品的发射光的至少两种光学性质的方法。 该方法包括：将板的孔与多个球透镜（205）对准，将来自适当光源（201）的电磁辐射同轴地穿过每个球透镜的对称轴线，并检测由球透镜聚焦的发射光 从样品。
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3.发明公开LOW BACKGROUND MULTI-WELL PLATES FOR FLUORESCENCE MEASUREMENTS OF BIOLOGICAL AND BIOCHEMICAL SAMPLES 失效MEHRGEFÄSSPLATTENMIT KLEINERSTÖRSTRAHLUNGFÜRFLUORESZENZMESSUNGEN VON BIOLOGISCHEN UND BIOCHEMISCHEN PROBEN
公开(公告)号：EP0921857A4
公开(公告)日：2000-10-04
申请号：EP98925058
申请日：1998-05-29
Applicant: AURORA BIOSCIENCES CORP
Inventor： PHAM ANDREW A , COASSIN PETER J , HAROOTUNIAN ALEC TATE , MENDLEIN JOHN D , TSIEN ROGER Y
CPC classification number: B01L3/5085 , B01J2219/00317 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01L2200/12 , B01L2300/0829 , B01L2300/12 , C40B60/14
Abstract: The invention provides for multi-well plates and platforms that comprise a layer of having low fluorescence and high transmittance. These multi-well plates and platforms are particularly well suited for fluorescent measurements.
Abstract translation: 本发明提供了包括具有低荧光和高透射率的层的多孔板和平台。 这些多孔板和平台特别适用于荧光测量。
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4.发明公开LOW FLUORESCENCE ASSAY PLATFORMS AND RELATED METHODS FOR DRUG DISCOVERY 审中-公开平台的低荧光的测定方法和MEDIKAMENTENAUFSPÜRUNG相关方法
公开(公告)号：EP1066400A4
公开(公告)日：2004-09-08
申请号：EP99908436
申请日：1999-02-24
Applicant: AURORA BIOSCIENCES CORP
Inventor： COASSIN PETER J , HAROOTUNIAN ALEC TATE , STYLLI HARRY , TSIEN ROGER Y , PHAM ANDREW A
CPC classification number: B01L3/5085 , B01J2219/00315 , B01J2219/00317 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01L9/523 , B01L2300/0829 , C40B60/14 , G01N2021/0346 , Y10S435/968 , Y10S435/975
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公开(公告)号：AU5108199A
公开(公告)日：2000-02-07
申请号：AU5108199
申请日：1999-07-16
Applicant: AURORA BIOSCIENCES CORP
Inventor： TSIEN ROGER Y , COASSIN PETER J , PHAM ANDREW A , HAROOTUNIAN ALEC TATE , VUONG MINH
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Patent Agency Ranking
公开(公告)号：CA2278045A1
公开(公告)日：2000-01-17
申请号：CA2278045
申请日：1999-07-19
Applicant: AURORA BIOSCIENCES CORP
Inventor： HAROOTUNIAN ALEC TATE , TSIEN ROGER Y , VUONG MINH , PHAM ANDREW A , COASSIN PETER J
IPC: G01N21/64 , G01N1/00 , G01N21/03 , G01N21/25 , G01N35/02 , G01N37/00 , G02B6/04 , G01N21/00 , G01N33/487
Abstract: The invention provides for a detector assembly, fiber assembly and screening system for optical measurements.
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公开(公告)号：CA2271373A1
公开(公告)日：1999-08-24
申请号：CA2271373
申请日：1999-02-24
Applicant: AURORA BIOSCIENCES CORP
Inventor： TSIEN ROGER Y , STYLLI HARRY , PHAM ANDREW A , HAROOTUNIAN ALEC TATE , COASSIN PETER J
Abstract: One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the mufti-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform for fluorescence measurements. A further aspect of the present invention is a method for detecting the presence of an analyte in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a method from identifying a modulator of a biological process or target in a sample contained in a multiwell platform by detecting light emitted from the sample. Another aspect of the present invention is a composition identified by this method. A further aspect of the present invention is a method to identify a therapeutic. A further aspect of the present invention is a method of testing a therapeutic for therapeutic activity and toxicology by identifying a therapeutic using a method of the present invention and monitoring the toxicology and efficacy of the therapeutic in an in vivo model.
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公开(公告)号：CA2271373C
公开(公告)日：2014-05-13
申请号：CA2271373
申请日：1999-02-24
Applicant: AURORA BIOSCIENCES CORP
Inventor： COASSIN PETER J , HAROOTUNIAN ALEC TATE , PHAM ANDREW A , STYLLI HARRY , TSIEN ROGER Y
Abstract: One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the multi-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform for fluorescence measurements. A further aspect of the present invention is a method for detecting the presence of an analyte in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a method from identifying a modulator of a biological process or target in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a composition identified by this method. A further aspect of the present invention is a method to identify a therapeutic. A further aspect of the present invention is a method of testing a therapeutic for therapeutic activity and toxicology by identifying a therapeutic using a method of the present invention and monitoring the toxicology and efficacy of the therapeutic in an in vivo model.
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公开(公告)号：AU2787099A
公开(公告)日：1999-09-06
申请号：AU2787099
申请日：1999-02-24
Applicant: AURORA BIOSCIENCES CORP
Inventor： COASSIN PETER J , HAROOTUNIAN ALEC TATE , STYLLI HARRY , TSIEN ROGER Y , PHAM ANDREW A
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10.发明专利
公开(公告)号：CA2262739C
公开(公告)日：2003-11-04
申请号：CA2262739
申请日：1998-05-29
Applicant: AURORA BIOSCIENCES CORP
Inventor： PHAM ANDREW A , HAROOTUNIAN ALEC TATE , COASSIN PETER J , MENDLEIN JOHN D , TSIEN ROGER Y
Abstract: The invention provides for multi-well plates and platforms that comprise a layer of having low fluorescence and high transmittance. These multi-well plates and platforms are particularly well suited for fluorescent measuremen ts.
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