公开(公告)号：EP1066253B1

公开(公告)日：2004-06-23

申请号：EP99914082.5

申请日：1999-03-23

Applicant: ABBOTT LABORATORIES

Inventor： WANG, Xiu, C. ,  BHATIA, Ashok, V. ,  HOSSAIN, Azad ,  TOWNE, Timothy, B.

IPC: C07C403/20

CPC classification number: C07C403/20 ,  C07B2200/09 ,  C07C2601/16

Abstract: The process of the present invention relates to a process for producing 13-cis retinoic acid. The process of the present invention involves reacting a Wittig salt in a solvent with a butenolide in the presence of a weak base and optionally, a Lewis acid.

Abstract translation: 本发明的方法涉及一种生产13-顺式视黄酸的方法。 本发明的方法包括在弱碱和路易斯酸的存在下使Wittig盐在溶剂中与丁烯内酯反应。

公开(公告)号：EP1257531B1

公开(公告)日：2004-09-15

申请号：EP01916231.2

申请日：2001-02-23

Applicant: Abbott Laboratories

Inventor： BARKALOW, Jufang ,  CHAMBERLIN, Steven, A. ,  COOPER, Arthur, J. ,  HOSSAIN, Azad ,  HUFNAGEL, John, J. ,  LANGRIDGE, Denton, C.

IPC: C07C327/02 ,  C07J31/00

CPC classification number: C07C327/02 ,  C07J31/003

Abstract: This invention discloses a novel method for the conversion of carboxylic acids to carbothioic acids and application of the method to the preparation of androstane carbothiolates, such as fluticasone propionate, which avoids column chromatography.

公开(公告)号：EP1257531A2

公开(公告)日：2002-11-20

申请号：EP01916231.2

申请日：2001-02-23

Applicant: Abbott Laboratories

Inventor： BARKALOW, Jufang ,  CHAMBERLIN, Steven, A. ,  COOPER, Arthur, J. ,  HOSSAIN, Azad ,  HUFNAGEL, John, J. ,  LANGRIDGE, Denton, C.

IPC: C07C327/02 ,  C07J31/00

CPC classification number: C07C327/02 ,  C07J31/003

Abstract: This invention discloses a novel method for the conversion of carboxylic acids to carbothioic acids and application of the method to the preparation of androstane carbothiolates, such as fluticasone propionate, which avoids column chromatography.

公开(公告)号：EP1066253A1

公开(公告)日：2001-01-10

申请号：EP99914082.5

申请日：1999-03-23

Applicant: ABBOTT LABORATORIES

Inventor： WANG, Xiu, C. ,  BHATIA, Ashok, V. ,  HOSSAIN, Azad ,  TOWNE, Timothy, B.

IPC: C07C403/20

CPC classification number: C07C403/20 ,  C07B2200/09 ,  C07C2601/16

Abstract: The process of the present invention relates to a process for producing 13-cis retinoic acid. The process of the present invention involves reacting a Wittig salt in a solvent with a butenolide in the presence of a weak base and optionally, a Lewis acid.

Abstract translation: 本发明的方法涉及生产13-顺式视黄酸的方法。 本发明的方法涉及使Wittig盐在溶剂中与丁烯内酯在弱碱和任选的路易斯酸存在下反应。