公开(公告)号：WO2011112558A2

公开(公告)日：2011-09-15

申请号：PCT/US2011/027511

申请日：2011-03-08

Applicant: ABBOTT LABORATORIES ,  ENANTA PHARMACEUTICALS INC. ,  LIEPOLD, Bernd ,  ROSENBLATT, Karin ,  HÖLIG, Peter ,  GOKHALE, Rajeev ,  PRASAD, Leena ,  MILLER, Jonathan ,  SCHMITT, Eric, A. ,  MORRIS, John, B.

Inventor： LIEPOLD, Bernd ,  ROSENBLATT, Karin ,  HÖLIG, Peter ,  GOKHALE, Rajeev ,  PRASAD, Leena ,  MILLER, Jonathan ,  SCHMITT, Eric, A. ,  MORRIS, John, B.

CPC classification number: A61K9/10 ,  A61K9/146 ,  A61K9/1635 ,  A61K9/1694 ,  A61K9/2027 ,  A61K31/497 ,  A61K2300/00

Abstract: The present invention features solid compositions comprising amorphous Compound I. A solid dispersion of the present invention also contains a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant. Compound I may be formulated in an amorphous solid dispersion which comprises a pharmaceutically acceptable hydrophilic polymer and preferably a pharmaceutically acceptable surfactant.

Abstract translation: 本发明的特征在于包含无定形化合物I的固体组合物。本发明的固体分散体还含有药学上可接受的亲水性聚合物和可药用的表面活性剂。 化合物I可以配制成包含药学上可接受的亲水性聚合物和优选药学上可接受的表面活性剂的无定形固体分散体。

公开(公告)号：EP2544689A2

公开(公告)日：2013-01-16

申请号：EP11753907.2

申请日：2011-03-08

Applicant: Abbott Laboratories

Inventor： LIEPOLD, Bernd ,  ROSENBLATT, Karin ,  HÖLIG, Peter ,  GOKHALE, Rajeev ,  PRASAD, Leena ,  MILLER, Jonathan ,  SCHMITT, Eric, A. ,  MORRIS, John, B.

IPC: A61K31/4965 ,  A61K31/498 ,  A61K31/395 ,  A61K9/20 ,  A61K47/30 ,  A61P31/14

CPC classification number: A61K9/10 ,  A61K9/146 ,  A61K9/1635 ,  A61K9/1694 ,  A61K9/2027 ,  A61K31/497 ,  A61K2300/00

Abstract: The present invention features solid compositions comprising amorphous Compound I. A solid dispersion of the present invention also contains a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant. Compound I may be formulated in an amorphous solid dispersion which comprises a pharmaceutically acceptable hydrophilic polymer and preferably a pharmaceutically acceptable surfactant.

Abstract translation: 本发明的特征在于包含无定形化合物I的固体组合物。 化合物I可以配制成无定形固体分散体，其包含药学上可接受的亲水聚合物并优选药学上可接受的表面活性剂