公开(公告)号：EP1066304A1

公开(公告)日：2001-01-10

申请号：EP99912259.1

申请日：1999-03-11

Applicant: ABBOTT LABORATORIES

Inventor： SAUER, Daryl, R. ,  HAVIV, Fortuna ,  RANDOLPH, John ,  MORT, Nicholas, A. ,  DALTON, Christopher, R. ,  BRUNCKO, Milan ,  KAMINSKI, Michele, A. ,  CRAWFORD, Bradley, W. ,  FREY, Lisa, Marie ,  GREER, Jonathon

IPC: C07H1/00

CPC classification number: C07H17/08

Abstract: Disclosed are 3'-N-desmethyl-3'-N-susbstituted-6-O-methyl-11-deoxy-11, 12-cyclic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.

公开(公告)号：EP1066304B1

公开(公告)日：2005-02-23

申请号：EP99912259.1

申请日：1999-03-11

Applicant: Abbott Laboratories

Inventor： SAUER, Daryl, R. ,  HAVIV, Fortuna ,  RANDOLPH, John ,  MORT, Nicholas, A. ,  DALTON, Christopher, R. ,  BRUNCKO, Milan ,  KAMINSKI, Michele, A. ,  CRAWFORD, Bradley, W. ,  FREY, Lisa, Marie ,  GREER, Jonathon

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08

Abstract: Disclosed are 3'-N-desmethyl-3'-N-susbstituted-6-O-methyl-11-deoxy-11, 12-cyclic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.

公开(公告)号：EP1066307A1

公开(公告)日：2001-01-10

申请号：EP99914036.1

申请日：1999-03-22

Applicant: ABBOTT LABORATORIES

Inventor： SAUER, Daryl, R. ,  HAVIV, Fortuna ,  RANDOLPH, John ,  MORT, Nicholas, A. ,  DALTON, Christopher, R. ,  BRUNCKO, Milan ,  KAMINSKI, Michele, A. ,  CRAWFORD, Bradley, W. ,  FREY, Lisa, Marie ,  GREER, Jonathon

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08

Abstract: Disclosed are 3',3'-N-bisdesmethyl-3',3'-N-bis-substituted-6-O-methyl-11-deoxy-11,12-cyclic carbamate erythromycin A derivatives of formula (I) which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, methods of using the compounds and the process of making the same.