公开(公告)号：WO2004043298A1

公开(公告)日：2004-05-27

申请号：PCT/US2003/035563

申请日：2003-11-07

Applicant: ABBOTT LABORATORIES ,  VERLEE, Donald ,  CROMACK, Keith ,  TARCHA, Peter ,  TONER, John ,  BURKE, Sandra ,  CLIFFORD, Anton ,  FISHER, Charles

Inventor： VERLEE, Donald ,  CROMACK, Keith ,  TARCHA, Peter ,  TONER, John ,  BURKE, Sandra ,  CLIFFORD, Anton ,  FISHER, Charles

IPC: A61F2/06

CPC classification number: B05C13/025 ,  A61F2/852 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2/962 ,  A61F2002/065 ,  A61F2002/067 ,  A61F2002/825 ,  A61F2002/826 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61F2250/0098 ,  B05C5/0216 ,  G11B7/00

Abstract: An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The interventional device has a controlled local areal density of beneficial agent for systemic delivery or delivery to the luminal wall. The local areal density of beneficial agent may be varied along the prosthesis. The interventional device includes overlapping or bifurcated stents having a controlled areal density of beneficial agent.

Abstract translation: 用于将有益剂递送到管腔的介入装置及其装载和制造方法，其包括装载有益剂的假体，以向受管腔提供受控剂量浓度的有益剂。 有益剂通过流体分配器装载到假体上，流体分配器具有能够以离散液滴分配有益剂的分配元件，每个液滴具有受控的轨迹。 介入装置具有受控的局部面积密度，用于全身输送或输送到腔壁的有益药剂。 有益药剂的局部面积密度可以沿着假体变化。 介入装置包括具有受控面积密度的有效试剂的重叠或分叉支架。

公开(公告)号：WO2004043300A1

公开(公告)日：2004-05-27

申请号：PCT/US2003/035627

申请日：2003-11-07

Applicant: ABBOTT LABORATORIES ,  VERLEE, Donald ,  CROMACK, Keith ,  TARCHA, Peter ,  TONER, John ,  HUI, Ho-Wa

Inventor： VERLEE, Donald ,  CROMACK, Keith ,  TARCHA, Peter ,  TONER, John ,  HUI, Ho-Wa

IPC: A61F2/06

CPC classification number: B05C13/025 ,  A61F2/852 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2/962 ,  A61F2002/065 ,  A61F2002/067 ,  A61F2002/825 ,  A61F2002/826 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61F2250/0098 ,  B05C5/0216 ,  G11B7/00

Abstract: An interventional device for delivery of multiple beneficial agents. The device includes a prosthesis having a surface loaded with a plurality of discrete droplets of first and second beneficial agents. The discrete droplets of beneficial agent are loaded along a first controlled trajectory and the second beneficial agent is loaded along a second controlled trajectory. The first controlled trajectory and the second controlled trajectory can be aligned to allow mixing of the first and second beneficial agents prior to being loaded onto the surface of the prosthesis.

Abstract translation: 用于递送多种有益药剂的介入装置。 该装置包括具有装载有第一和第二有益试剂的多个离散液滴的表面的假体。 沿着第一受控轨迹加载有益试剂的离散液滴，并且沿第二受控轨迹加载第二有益试剂。 第一受控轨迹和第二受控轨迹可以被对准以允许在被加载到假体的表面之前混合第一和第二有益试剂。

公开(公告)号：WO2004043299A1

公开(公告)日：2004-05-27

申请号：PCT/US2003/035624

申请日：2003-11-07

Applicant: ABBOTT LABORATORIES ,  VERLEE, Donald ,  TARCHA, Peter ,  CROMACK, Keith ,  QUINT, Richard

Inventor： VERLEE, Donald ,  TARCHA, Peter ,  CROMACK, Keith ,  QUINT, Richard

IPC: A61F2/06

CPC classification number: B05C13/025 ,  A61F2/852 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2/962 ,  A61F2002/065 ,  A61F2002/067 ,  A61F2002/825 ,  A61F2002/826 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61F2250/0098 ,  B05C5/0216 ,  G11B7/00

Abstract: An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The method of loading beneficial agent includes dispensing beneficial agent in a raster format and/or an off-axis format along a dispensing path.

Abstract translation: 用于将有益剂递送到管腔的介入装置及其装载和制造方法，其包括装载有益剂的假体，以向受管腔提供受控剂量浓度的有益剂。 有益剂通过流体分配器装载到假体上，流体分配器具有能够以离散液滴分配有益剂的分配元件，每个液滴具有受控的轨迹。 加载有益试剂的方法包括沿着分配路径以光栅格式和/或离轴格式分配有益试剂。

公开(公告)号：EP1572029B1

公开(公告)日：2010-03-24

申请号：EP03783257.3

申请日：2003-11-07

Applicant: ABBOTT LABORATORIES

Inventor： VERLEE, Donald ,  TARCHA, Peter ,  CROMACK, Keith ,  QUINT, Richard

IPC: A61F2/06 ,  B05C5/02

CPC classification number: B05C13/025 ,  A61F2/852 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2/962 ,  A61F2002/065 ,  A61F2002/067 ,  A61F2002/825 ,  A61F2002/826 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61F2250/0098 ,  B05C5/0216 ,  G11B7/00

Abstract: An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The method of loading beneficial agent includes dispensing beneficial agent in a raster format and/or an off-axis format along a dispensing path.

公开(公告)号：EP1011604A1

公开(公告)日：2000-06-28

申请号：EP98910096.1

申请日：1998-02-26

Applicant: Abbott Laboratories

Inventor： HELLSTROM, Steven, P. ,  KARAS, Peter, J. ,  MOORE, John, K. ,  NORMAN, John, S. ,  TANNER, John, C., II ,  VERLEE, Donald

IPC: A61J1/00

CPC classification number: A61J1/2096 ,  A61J1/201 ,  A61J1/2055 ,  A61J2205/20 ,  Y10S215/03

Abstract: A closure is provided for mounting across the mouth of a container and through which liquid can be withdrawn with a fluid transfer device having a male member. The closure includes a body for being disposed on the container across the container mouth. The body defines a passage with an exterior opening for matingly receiving the male member of the fluid transfer device. A frangible seal initially extends across the passage in the body to occlude the passage. The seal is broken when it is engaged by the male member of the fluid transfer device, thereby establishing fluid communication between the fluid transfer device and the interior of the container.

公开(公告)号：EP1572029A1

公开(公告)日：2005-09-14

申请号：EP03783257.3

申请日：2003-11-07

Applicant: ABBOTT LABORATORIES

Inventor： VERLEE, Donald ,  TARCHA, Peter ,  CROMACK, Keith ,  QUINT, Richard

IPC: A61F2/06 ,  B05C5/02

CPC classification number: B05C13/025 ,  A61F2/852 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2/962 ,  A61F2002/065 ,  A61F2002/067 ,  A61F2002/825 ,  A61F2002/826 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61F2250/0098 ,  B05C5/0216 ,  G11B7/00

Abstract: An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The method of loading beneficial agent includes dispensing beneficial agent in a raster format and/or an off-axis format along a dispensing path.

公开(公告)号：EP1011603A1

公开(公告)日：2000-06-28

申请号：EP98910086.2

申请日：1998-02-26

Applicant: Abbott Laboratories

Inventor： DAUBERT, Richard, F. ,  HELLSTROM, Steven, P. ,  KARAS, Peter, J. ,  MOORE, John, K. ,  NORMAN, John, S. ,  TANNER, John, C., II ,  VERLEE, Donald

IPC: A61J1/00

CPC classification number: A61J1/2096 ,  A61J1/1412 ,  A61J1/201 ,  A61J2200/10 ,  Y10S604/905

Abstract: A cap assembly is provided for mounting over the mouth of a container which is occluded with a stopper. The cap assembly includes a housing, a moveable piercing member or penetrator within the housing, a removable overcap over the housing, and a ferrule connecting the housing to the container. A preferred form of the penetrator is fabricated from sheet metal in a progressive die stamping process. One form of the overcap includes a frangible construction that permits the upper part of the overcap to be torn away to expose the upper portion of the housing.

公开(公告)号：EP1011602A1

公开(公告)日：2000-06-28

申请号：EP98910051.6

申请日：1998-02-26

Applicant: Abbott Laboratories

Inventor： DAUBERT, Richard, F. ,  HELLSTROM, Steven, P. ,  KARAS, Peter, J. ,  MOORE, John, K. ,  NORMAN, John, S. ,  TANNER, John, C., II ,  VERLEE, Donald

IPC: A61J1/00

CPC classification number: A61J1/2096 ,  A61J1/1412 ,  A61J1/201 ,  A61J2200/10 ,  Y10S604/905

Abstract: A penetrator for penetrating a stopper sealing an opening in a container. The penetrator includes a stamped piece of sheet material formed to define a shank having a length. A groove extends along the length of the shank. The shank has a pointed distal. The stamped piece of sheet material further includes a bearing plate extending from the shank at a proximal end opposite the distal end of the shank.

公开(公告)号：EP1562517B1

公开(公告)日：2010-06-16

申请号：EP03783258.1

申请日：2003-11-07

Applicant: Abbott Laboratories

Inventor： VERLEE, Donald ,  CROMACK, Keith ,  TARCHA, Peter ,  TONER, John ,  HUI, Ho-Wa

IPC: A61F2/06

CPC classification number: B05C13/025 ,  A61F2/852 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2/962 ,  A61F2002/065 ,  A61F2002/067 ,  A61F2002/825 ,  A61F2002/826 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61F2250/0098 ,  B05C5/0216 ,  G11B7/00

Abstract: An interventional device for delivery of multiple beneficial agents. The device includes a prosthesis having a surface loaded with a plurality of discrete droplets of first and second beneficial agents. The discrete droplets of beneficial agent are loaded along a first controlled trajectory and the second beneficial agent is loaded along a second controlled trajectory. The first controlled trajectory and the second controlled trajectory can be aligned to allow mixing of the first and second beneficial agents prior to being loaded onto the surface of the prosthesis.

公开(公告)号：EP1562518A1

公开(公告)日：2005-08-17

申请号：EP03786605.0

申请日：2003-11-07

Applicant: Abbott Laboratories ,  Verlee, Donald ,  Cromack, Keith ,  Tarcha, Peter ,  Toner, John

Inventor： VERLEE, Donald ,  CROMACK, Keith ,  TARCHA, Peter ,  TONER, John ,  BURKE, Sandra ,  CLIFFORD, Anton ,  FISHER, Charles

IPC: A61F2/06

CPC classification number: B05C13/025 ,  A61F2/852 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2/962 ,  A61F2002/065 ,  A61F2002/067 ,  A61F2002/825 ,  A61F2002/826 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61F2250/0098 ,  B05C5/0216 ,  G11B7/00

Abstract: An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The interventional device has a controlled local areal density of beneficial agent for systemic delivery or delivery to the luminal wall. The local areal density of beneficial agent may be varied along the prosthesis. The interventional device includes overlapping or bifurcated stents having a controlled areal density of beneficial agent.