公开(公告)号：US09539222B2

公开(公告)日：2017-01-10

申请号：US14426659

申请日：2013-09-04

Applicant: Agency for Science, Technology and Research

Inventor： Amit Singhal ,  Gennaro De Libero

IPC: A61K31/155 ,  A61K31/343 ,  A61K45/06 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/05 ,  A61K31/7076 ,  A61K31/277 ,  A61K31/40 ,  A61K31/4409 ,  A61K31/451 ,  A61K31/675 ,  A61K31/553 ,  A61K31/4178 ,  A61K31/421

CPC classification number: A61K31/155 ,  A61K31/05 ,  A61K31/277 ,  A61K31/343 ,  A61K31/40 ,  A61K31/4178 ,  A61K31/421 ,  A61K31/4409 ,  A61K31/4422 ,  A61K31/451 ,  A61K31/52 ,  A61K31/553 ,  A61K31/675 ,  A61K31/7056 ,  A61K31/7076 ,  A61K45/06 ,  A61K2300/00

Abstract: Disclosed is a method of preventing, treating or inhibiting bacterial infections. The method comprises administering at least one of the compounds disclosed herein. Also disclosed are methods of increasing acidity of bacterial phagosomes to inhibit bacterial growth, methods of increasing mitochondrial reactive oxygen species (mROS) generation to inhibit bacterial growth in a cell, pharmaceutical compositions and uses thereof.

Abstract translation: 公开了一种预防，治疗或抑制细菌感染的方法。 该方法包括施用本文公开的至少一种化合物。 还公开了增加细菌吞噬体抑制细菌生长的酸度的方法，增加线粒体活性氧（mROS）产生以抑制细胞中的细菌生长的方法，药物组合物及其用途。

公开(公告)号：US20250043270A1

公开(公告)日：2025-02-06

申请号：US18715366

申请日：2022-11-30

Applicant: Agency for Science, Technology and Research

Inventor： Amit Singhal ,  Kumar Dilip

IPC: C12N15/10 ,  A61K35/28 ,  A61K45/06 ,  A61P35/02 ,  C12N5/0789

Abstract: There is provided a genetically modified cell wherein at least one gene has been deleted from the cell and the gene is selected from the group consisting of p50, p52, p65, c-Rel, and RelB. Also disclosed are methods of identifying a target for treating acute myeloid leukemia (AML) in a subject, methods of treating acute myeloid leukemia (AML) in a subject in need thereof, comprising inhibiting the activity of an NF-KB pathway. Also provided is an ATP13A2 inhibiting agent for use in therapy or medicine, for use in treating AML, and in the manufacture of a medicament for treating AML.

公开(公告)号：US20150209308A1

公开(公告)日：2015-07-30

申请号：US14426659

申请日：2013-09-04

Applicant: AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH

Inventor： Amit Singhal ,  Gennaro De Libero

IPC: A61K31/155 ,  A61K31/4422 ,  A61K31/40 ,  A61K31/7076 ,  A61K31/4409 ,  A61K31/421 ,  A61K31/553 ,  A61K31/343 ,  A61K31/05 ,  A61K31/675 ,  A61K45/06 ,  A61K31/451

CPC classification number: A61K31/155 ,  A61K31/05 ,  A61K31/277 ,  A61K31/343 ,  A61K31/40 ,  A61K31/4178 ,  A61K31/421 ,  A61K31/4409 ,  A61K31/4422 ,  A61K31/451 ,  A61K31/52 ,  A61K31/553 ,  A61K31/675 ,  A61K31/7056 ,  A61K31/7076 ,  A61K45/06 ,  A61K2300/00

Abstract: Disclosed is a method of preventing, treating or inhibiting bacterial infections. The method comprises administering at least one of the compounds disclosed herein. Also disclosed are methods of increasing acidity of bacterial phagosomes to inhibit bacterial growth, methods of increasing mitochondrial reactive oxygen species (mROS) generation to inhibit bacterial growth in a cell, pharmaceutical compositions and uses thereof.

Abstract translation: 公开了一种预防，治疗或抑制细菌感染的方法。 该方法包括施用本文公开的至少一种化合物。 还公开了增加细菌吞噬体抑制细菌生长的酸度的方法，增加线粒体活性氧（mROS）产生以抑制细胞中的细菌生长的方法，药物组合物及其用途。