公开(公告)号：WO2007139511A1

公开(公告)日：2007-12-06

申请号：PCT/SG2006/000137

申请日：2006-05-31

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  AGARWAL, Ajay ,  BALASUBRAMANIAN, Narayanan ,  GUO, Lihui ,  WONG, Chee Chung

Inventor： AGARWAL, Ajay ,  BALASUBRAMANIAN, Narayanan ,  GUO, Lihui ,  WONG, Chee Chung

IPC: G01N33/487 ,  B01L3/00 ,  G01N1/10

CPC classification number: B81B1/00 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/12 ,  B81B2201/058 ,  G01N33/48728 ,  G01N2021/0346 ,  G01N2035/00158 ,  Y10T436/143333

Abstract: A device for analysing the status of a biological entity. The device (10) comprises a substantially transparent base substrate (11) having a recess defined therein by at least two opposing lateral walls and a base wall, a substantially transparent filler member (14) having at least a portion thereof occupying the recess, a substantially transparent separation layer (12) disposed between the filler member and the base substrate, and a channel (16) defined in the filler member, wherein the channel comprises an inlet and an outlet, the inlet being arranged on a first lateral wall of the filler member, and the outlet being arranged on a second lateral wall of the filler member, said first lateral wall of the filler member being arranged in opposing relationship with the second lateral wall of the filler member, and at least a portion of the first and the second lateral walls of the filler member being at least substantially perpendicular to the opposing lateral walls defining the recess.

Abstract translation: 用于分析生物实体状态的装置。 装置（10）包括基本上透明的基底（11），其具有通过至少两个相对的侧壁和底壁限定的凹部，基本上透明的填充构件（14），其至少部分占据凹部， 设置在填充构件和基底衬底之间的基本上透明的分离层（12）和限定在填充构件中的通道（16），其中通道包括入口和出口，入口布置在第一侧壁 填料构件，并且出口布置在填料构件的第二侧壁上，填料构件的所述第一侧壁与填料构件的第二侧壁相对置，并且第一和第二侧壁的至少一部分 填充构件的第二侧壁至少基本上垂直于限定凹部的相对侧壁。

公开(公告)号：WO2008018834A1

公开(公告)日：2008-02-14

申请号：PCT/SG2006/000227

申请日：2006-08-11

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  AGARWAL, Ajay ,  SINGH, Navab ,  KUMAR, Rakesh ,  LAO, Ieng Kin ,  BALASUBRAMANIAN, Narayanan

Inventor： AGARWAL, Ajay ,  SINGH, Navab ,  KUMAR, Rakesh ,  LAO, Ieng Kin ,  BALASUBRAMANIAN, Narayanan

IPC: B82B1/00 ,  B82B3/00

CPC classification number: B01J19/0046 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00612 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B81B2201/0214 ,  B81B2203/0338 ,  B81B2207/07 ,  B81C1/00119 ,  B82Y15/00 ,  C40B60/12 ,  Y10S977/957 ,  Y10S977/958

Abstract: A method of fabricating a sensor comprising a nanowire on a support substrate with a first semiconductor layer arranged on the support substrate is disclosed. The method comprises forming a fin structure from the first semiconductor layer, the fin structure comprising at least two supporting portions and a fin portion arranged there between; oxidizing at least the fin portion of the fin structure thereby forming the nanowire being surrounded by a first layer of oxide; and forming an insulating layer above the supporting portions; wherein the supporting portions and the first insulating layer form a microfluidic channel. A nanowire sensor is also disclosed. The nanowire sensor comprises a support substrate, a semiconducting fin structure arranged on the support substrate, the fin structure comprising at least two semiconducting supporting portions and a nanowire arranged there between; and a first insulating layer on a contact surface of the supporting portions; wherein the supporting portions and the first insulating layer form a microfluidic channel.

Abstract translation: 公开了一种制造传感器的方法，该传感器包括在支撑衬底上的纳米线，其中第一半导体层布置在支撑衬底上。 该方法包括从第一半导体层形成翅片结构，鳍结构包括至少两个支撑部分和布置在其间的翅片部分; 至少氧化翅片结构的翅片部分，从而形成由第一氧化物层包围的纳米线; 以及在所述支撑部分上方形成绝缘层; 其中所述支撑部分和所述第一绝缘层形成微流体通道。 还公开了一种纳米线传感器。 纳米线传感器包括支撑衬底，布置在支撑衬底上的半导体翅片结构，鳍结构包括至少两个半导体支撑部分和布置在其上的纳米线; 以及在所述支撑部分的接触表面上的第一绝缘层; 其中所述支撑部分和所述第一绝缘层形成微流体通道。

公开(公告)号：EP2049436B1

公开(公告)日：2012-10-17

申请号：EP06784252.6

申请日：2006-08-11

Applicant: Agency for Science, Technology and Research

Inventor： AGARWAL, Ajay ,  SINGH, Navab ,  KUMAR, Rakesh ,  LAO, Ieng Kin ,  BALASUBRAMANIAN, Narayanan

IPC: B01L3/00 ,  C40B60/12

CPC classification number: B01J19/0046 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00612 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B81B2201/0214 ,  B81B2203/0338 ,  B81B2207/07 ,  B81C1/00119 ,  B82Y15/00 ,  C40B60/12 ,  Y10S977/957 ,  Y10S977/958

公开(公告)号：EP2049436A1

公开(公告)日：2009-04-22

申请号：EP06784252.6

申请日：2006-08-11

Applicant: Agency for Science, Technology and Research (A*STAR)

Inventor： AGARWAL, Ajay ,  SINGH, Navab ,  KUMAR, Rakesh ,  LAO, Ieng Kin ,  BALASUBRAMANIAN, Narayanan

IPC: B82B1/00 ,  B82B3/00

CPC classification number: B01J19/0046 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00612 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B81B2201/0214 ,  B81B2203/0338 ,  B81B2207/07 ,  B81C1/00119 ,  B82Y15/00 ,  C40B60/12 ,  Y10S977/957 ,  Y10S977/958

Abstract: A method of fabricating a sensor comprising a nanowire on a support substrate with a first semiconductor layer arranged on the support substrate is disclosed. The method comprises forming a fin structure from the first semiconductor layer, the fin structure comprising at least two supporting portions and a fin portion arranged there between; oxidizing at least the fin portion of the fin structure thereby forming the nanowire being surrounded by a first layer of oxide; and forming an insulating layer above the supporting portions; wherein the supporting portions and the first insulating layer form a microfluidic channel. A nanowire sensor is also disclosed. The nanowire sensor comprises a support substrate, a semiconducting fin structure arranged on the support substrate, the fin structure comprising at least two semiconducting supporting portions and a nanowire arranged there between; and a first insulating layer on a contact surface of the supporting portions; wherein the supporting portions and the first insulating layer form a microfluidic channel.

公开(公告)号：EP2021790A1

公开(公告)日：2009-02-11

申请号：EP06748090.5

申请日：2006-05-31

Applicant: Agency for Science, Technology and Research

Inventor： AGARWAL, Ajay ,  BALASUBRAMANIAN, Narayanan ,  GUO, Lihui ,  WONG, Chee Chung

IPC: G01N33/487 ,  B01L3/00 ,  G01N1/10

CPC classification number: B81B1/00 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/12 ,  B81B2201/058 ,  G01N33/48728 ,  G01N2021/0346 ,  G01N2035/00158 ,  Y10T436/143333

Abstract: A device for analysing the status of a biological entity. The device (10) comprises a substantially transparent base substrate (11) having a recess defined therein by at least two opposing lateral walls and a base wall, a substantially transparent filler member (14) having at least a portion thereof occupying the recess, a substantially transparent separation layer (12) disposed between the filler member and the base substrate, and a channel (16) defined in the filler member, wherein the channel comprises an inlet and an outlet, the inlet being arranged on a first lateral wall of the filler member, and the outlet being arranged on a second lateral wall of the filler member, said first lateral wall of the filler member being arranged in opposing relationship with the second lateral wall of the filler member, and at least a portion of the first and the second lateral walls of the filler member being at least substantially perpendicular to the opposing lateral walls defining the recess.