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    VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS
    2.
    发明申请
    VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS 审中-公开
    VANILLOID受体配体及其在治疗中的应用

    公开(公告)号：WO2006113769A1

    公开(公告)日：2006-10-26

    申请号：PCT/US2006/014666

    申请日：2006-04-17

    Applicant: AMGEN INC.

    Inventor： DOHERTY, Elizabeth M. ,  LIAO, Hongyu ,  NORMAN, Mark H. ,  RETZ, Daniel Martin

    IPC: C07D401/14 ,  C07D403/12 ,  C07D417/14 ,  A61K31/506 ,  A61P29/00

    CPC classification number: C07D417/14 ,  C07D401/14 ,  C07D403/12

    Abstract: Compounds having the general structure ( formula (I)) and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

    Abstract translation: 具有一般结构的化合物（式（I））和含有它们的组合物用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管性综合征，紧张性头痛， 一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛和相关的痛觉过敏和异常性疼痛，神经性疼痛和相关痛觉过敏，以及 异常性疼痛，糖尿病性神经病疼痛，灼痛，交感神经保持性疼痛，交感综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动性紊乱，泌尿生殖道，胃肠道或血管区域，伤口，烧伤，过敏性皮肤反应，瘙痒， 白癜风，一般胃肠炎 胃溃疡，十二指肠溃疡，腹泻，坏死因子诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

    VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS
    4.
    发明申请
    VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS 审中-公开
    VANILLOID受体配体及其在治疗中的应用

    公开(公告)号：WO2006116563A1

    公开(公告)日：2006-11-02

    申请号：PCT/US2006/015947

    申请日：2006-04-25

    Applicant: AMGEN INC.

    Inventor： DOHERTY, Elizabeth M. ,  KATON, Jodie ,  NORMAN, Mark H. ,  RETZ, Daniel Martin ,  WANG, Xianghong ,  BO, Yunxin Y. ,  TAMAYO, Nuria ,  NISHIMURA, Nobuko ,  LIAO, Hongyu

    IPC: C07D239/42 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D413/04 ,  C07D403/12 ,  C07D213/74 ,  C07D401/10 ,  A61P29/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/451

    CPC classification number: C07D413/04 ,  C07D213/74 ,  C07D239/42 ,  C07D239/48 ,  C07D401/04 ,  C07D403/12 ,  C07D405/14

    Abstract: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

    Abstract translation: 具有一般结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性 疾病，骨关节炎，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛， 咳嗽痛，交感神经痛，交感综合症，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸系统内脏运动紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风， G 腹部溃疡，十二指肠溃疡，腹泻，坏死因子诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

    PYRIMIDINE DERIVATIVES FOR USE AS VANILLOID RECEPTOR LIGANDS AND THEIR USE IN THE TREATMENT OF PAIN
    6.
    发明申请
    PYRIMIDINE DERIVATIVES FOR USE AS VANILLOID RECEPTOR LIGANDS AND THEIR USE IN THE TREATMENT OF PAIN 审中-公开
    用作VANILLOID受体配体的吡嗪衍生物及其在治疗疼痛中的应用

    公开(公告)号：WO2005077944A1

    公开(公告)日：2005-08-25

    申请号：PCT/US2005/004378

    申请日：2005-02-11

    Applicant: AMGEN INC.

    Inventor： WANG, Hui-Ling ,  BALAN, Chenera ,  DOHERTY, Elizabeth M. ,  FALSEY, James R. ,  GORE, Vijay Keshav ,  KATON, Jodie ,  NORMAN, Mark H.

    IPC: C07D417/12

    CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

    Abstract: Pyrimidine ethers and compositions containing them, fo use as vanilloid receptor ligands for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders. Wherein R 1 - R 4 and X are as defined in the claims.

    Abstract translation: 嘧啶醚和含有它们的组合物，用作治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管性综合征，紧张性头痛，一般炎症， 关节炎，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病 神经病痛，咳嗽痛，交感神经保持疼痛，交感综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动性紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般 gastrointesti 鼻坏死症，胃溃疡，十二指肠溃疡，腹泻，坏死因子诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。 其中R 1至R 4和X如权利要求中所定义。

    VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS
    7.
    发明申请
    VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS 审中-公开
    VANILLOID受体配体及其在治疗中的应用

    公开(公告)号：WO2005077938A1

    公开(公告)日：2005-08-25

    申请号：PCT/US2005/004370

    申请日：2005-02-11

    Applicant: AMGEN INC.

    Inventor： BALAN, Chenera ,  CHEN, Ning ,  DOHERTY, Elizabeth M. ,  GORE, Vijay Keshav ,  NORMAN, Mark H. ,  WANG, Hui-Ling

    IPC: C07D401/12

    CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

    Abstract: Compounds having the general structure (I) and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndroms, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

    Abstract translation: 具有一般结构（I）的化合物和含有它们的组合物用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管性综合征，紧张性头痛，一般炎症， 关节炎，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病 神经病痛，咳嗽痛，交感神经保持疼痛，交感综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般 胃肠道疾病 胃溃疡，十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

    HETEROCYCLIC COMPOUNDS AS RAF KINASE MODULATORS
    8.
    发明公开
    HETEROCYCLIC COMPOUNDS AS RAF KINASE MODULATORS 审中-公开
    RAF激酶杂环化合物AS调节剂

    公开(公告)号：EP2170887A2

    公开(公告)日：2010-04-07

    申请号：EP08768206.8

    申请日：2008-06-05

    Applicant: Amgen Inc.

    Inventor： SMITH, Adrian L. ,  DOHERTY, Elizabeth M. ,  HUANG, Qi ,  LIU, Gang

    IPC: C07D473/00 ,  C07D487/04 ,  A61K31/519 ,  A61K31/52 ,  A61P35/00

    CPC classification number: C07D487/04 ,  C07D473/00

    Abstract: The present invention comprises a new class of compounds capable of modulating the activity of Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula (I) wherein each of A1, A2, A3, A4, A5, A6, A7, A8, A9, bond B, X, rings Z1 and Z2, R1 and R3 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.

    VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS
    10.
    发明公开
    VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS 审中-公开
    VANILLOIDREZEPTORLIGANDEN和它们在疗程组合

    公开(公告)号：EP1745034A1

    公开(公告)日：2007-01-24

    申请号：EP05722957.7

    申请日：2005-02-11

    Applicant: AMGEN INC.

    Inventor： BALAN, Chenera ,  CHEN, Ning ,  DOHERTY, Elizabeth M. ,  GORE, Vijay Keshav ,  NORMAN, Mark H. ,  WANG, Hui-Ling

    IPC: C07D401/12 ,  C07D417/12 ,  C07D413/12 ,  C07D403/12 ,  C07D417/14 ,  C07D401/14 ,  C07D403/14 ,  A61K31/44 ,  A61K31/444

    CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

    Abstract: Compounds having the general structure (I) and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndroms, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

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