公开(公告)号：WO2009140320A1

公开(公告)日：2009-11-19

申请号：PCT/US2009/043691

申请日：2009-05-13

Applicant: ARRAY BIOPHARMA INC. ,  LE HUEROU, Yvan ,  BLAKE, James, F. ,  GUNWARDANA, Indrani, W. ,  MOHR, Pete ,  WALLACE, Eli, M. ,  WANG, Bin ,  CHICARELLI, Mark ,  LYON, Michael

Inventor： LE HUEROU, Yvan ,  BLAKE, James, F. ,  GUNWARDANA, Indrani, W. ,  MOHR, Pete ,  WALLACE, Eli, M. ,  WANG, Bin ,  CHICARELLI, Mark ,  LYON, Michael

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07D401/06 ,  C07D519/00

Abstract: Compounds of Formula (I) are useful for inhibition of CHKl and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式（I）的化合物可用于抑制CHK1和/或CHK2。 公开了使用式（I）化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：WO2015103133A1

公开(公告)日：2015-07-09

申请号：PCT/US2014/072547

申请日：2014-12-29

Applicant: GENENTECH, INC. ,  ARRAY BIOPHARMA INC.

Inventor： BLAKE, James, F. ,  COOK, Adam ,  GUNAWARDANA, Indrani, W. ,  HUNT, Kevin, W. ,  LYON, Michael ,  METCALF, Andrew, T. ,  MOHR, Peter, J. ,  MORENO, David, A. ,  NEWHOUSE, Brad ,  REN, Li ,  TANG, Tony, P. ,  THOMAS, Allen, A. ,  SCHWARZ, Jacob ,  SCHMIDT, Jane ,  GAZZARD, Lewis ,  CHEN, Huifen

IPC: A61P35/00 ,  A61K31/506 ,  C07D401/14 ,  C07D405/14 ,  C07D403/04 ,  C07D403/14 ,  C07D417/14

CPC classification number: A61K31/506 ,  A61K31/4439 ,  A61K31/444 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04

Abstract: Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 提供式I化合物或其立体异构体，互变异构体或其药学上可接受的盐，其可用于治疗过度增殖，疼痛和炎性疾病。 公开了使用式I化合物或其立体异构体，互变异构体或其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：WO2012154274A1

公开(公告)日：2012-11-15

申请号：PCT/US2012/026572

申请日：2012-02-24

Applicant: ARRAY BIOPHARMA INC. ,  BLAKE, James, F ,  DELISLE, Robert, Kirk ,  DE MEESE, Lisa, A. ,  GRAHAM, James, M. ,  LE HUEROU, Yvan ,  LYON, Michael ,  ROBINSON, John, E. ,  WALLACE, Eli, M. ,  WANG, Bin ,  XU, Rui

Inventor： BLAKE, James, F ,  DELISLE, Robert, Kirk ,  DE MEESE, Lisa, A. ,  GRAHAM, James, M. ,  LE HUEROU, Yvan ,  LYON, Michael ,  ROBINSON, John, E. ,  WALLACE, Eli, M. ,  WANG, Bin ,  XU, Rui

IPC: C07D401/06 ,  C07D471/04 ,  C07D519/00 ,  A61K31/4709 ,  A61P29/00

CPC classification number: C07D471/04 ,  C07D401/06 ,  C07D487/04 ,  C07D487/10 ,  C07D491/048 ,  C07D519/00

Abstract: Compounds of Formula I: in which R 1 , R 2 , R 3 , R 4 and R 10 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases.

Abstract translation: R 1，R 2，R 3，R 4和R 10具有本说明书中给出的含义的式I化合物是可用于治疗由PIM-1和/或PIM-2和/或PIM-2介导的疾病的受体酪氨酸抑制剂， 3激酶。

公开(公告)号：WO2007015824A3

公开(公告)日：2007-02-08

申请号：PCT/US2006/027738

申请日：2006-07-17

Applicant: INTERMUNE, INC. ,  ARRAY BIOPHARMA INC. ,  SEIWERT, Scott D. ,  BLATT, Lawrence M. ,  ANDREWS, Steven W. ,  MARTIN, Pierre ,  SCHUMACHER, Andreas ,  BARNETT, Bradley, R. ,  EARY, Todd, C. ,  KAUS, Robert ,  KERCHER, Timothy ,  LIU, Weidong ,  LYON, Michael ,  NICHOLS, Paul ,  WANG, Bin ,  SAMMAKIA, Tarek ,  KENNEDY, April ,  JIANG, Yutong

Inventor： SEIWERT, Scott D. ,  BLATT, Lawrence M. ,  ANDREWS, Steven W. ,  MARTIN, Pierre ,  SCHUMACHER, Andreas ,  BARNETT, Bradley, R. ,  EARY, Todd, C. ,  KAUS, Robert ,  KERCHER, Timothy ,  LIU, Weidong ,  LYON, Michael ,  NICHOLS, Paul ,  WANG, Bin ,  SAMMAKIA, Tarek ,  KENNEDY, April ,  JIANG, Yutong

IPC: C07K5/12 ,  A61K38/00 ,  A61P31/14 ,  C07D209/44 ,  C07C231/02 ,  C07C269/00 ,  C07D207/16

Abstract: The embodiments provide compounds of the general Formulae (I) through general Formula (VIII), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

公开(公告)号：WO2015103137A1

公开(公告)日：2015-07-09

申请号：PCT/US2014/072555

申请日：2014-12-29

Applicant: ARRAY BIOPHARMA INC. ,  GENENTECH, INC.

Inventor： BLAKE, James, F. ,  COOK, Adam ,  GAUDINO, John ,  GUNAWARDANA, Indrani, W. ,  HICKEN, Erik, James ,  HUNT, Kevin, W. ,  LYON, Michael ,  METCALF, Andrew, T. ,  MOHR, Peter, J. ,  MORENO, David, A. ,  NEWHOUSE, Brad ,  REN, Li ,  SCHWARZ, Jacob ,  CHEN, Huifen ,  GAZZARD, Lewis ,  SCHMIDT, Jane ,  DO, Steve

IPC: C07D487/04 ,  A61K31/444 ,  A61K31/506 ,  A61P29/00

CPC classification number: C07D471/04 ,  A61K31/444 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00

Abstract: Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.

Abstract translation: 提供式I化合物或其立体异构体，互变异构体或其药学上可接受的盐，其可用于治疗疾病。 公开了使用式I化合物或其立体异构体，互变异构体或其药学上可接受的盐在体外，原位和体内诊断，预防或治疗这些疾病或相关病理状况的方法。

公开(公告)号：WO2008137779A2

公开(公告)日：2008-11-13

申请号：PCT/US2008/062552

申请日：2008-05-02

Applicant: INTERMUNE, INC. ,  ARRAY BIOPHARMA, INC. ,  BLATT, Lawrence, M. ,  PAN, Lin ,  SEIWERT, Scott ,  ANDREWS, Steven, W. ,  MARTIN, Pierre ,  SCHUMACHER, Andreas ,  BEIGELMAN, Leonid ,  LIU, Jyanwei ,  CONDROSKI, Kevin ,  JIANG, Yutong ,  KAUS, Robert ,  KENNEDY, April ,  KERCHER, Timothy ,  LYON, Michael ,  WANG, Bin

Inventor： BLATT, Lawrence, M. ,  PAN, Lin ,  SEIWERT, Scott ,  ANDREWS, Steven, W. ,  MARTIN, Pierre ,  SCHUMACHER, Andreas ,  BEIGELMAN, Leonid ,  LIU, Jyanwei ,  CONDROSKI, Kevin ,  JIANG, Yutong ,  KAUS, Robert ,  KENNEDY, April ,  KERCHER, Timothy ,  LYON, Michael ,  WANG, Bin

IPC: C07D487/04 ,  C08H1/00 ,  A61K31/407 ,  A61P31/12

CPC classification number: C07D487/04

Abstract: The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Abstract translation: 实施方案提供了通式I的化合物，以及包含主题化合物的组合物，包括药物组合物。 实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

公开(公告)号：EP2678329A1

公开(公告)日：2014-01-01

申请号：EP12716770.8

申请日：2012-02-24

Applicant: Array Biopharma, Inc.

Inventor： BLAKE, James, F ,  DELISLE, Robert, Kirk ,  DE MEESE, Lisa, A. ,  GRAHAM, James, M. ,  LE HUEROU, Yvan ,  LYON, Michael ,  ROBINSON, John, E. ,  WALLACE, Eli, M. ,  WANG, Bin ,  XU, Rui

IPC: C07D401/06 ,  C07D471/04 ,  C07D519/00 ,  A61K31/4709 ,  A61P29/00

CPC classification number: C07D471/04 ,  C07D401/06 ,  C07D487/04 ,  C07D487/10 ,  C07D491/048 ,  C07D519/00

Abstract: Compounds of Formula I: in which R
1 , R
2 , R
3 , R
4 and R
10 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases.

公开(公告)号：EP2990407B1

公开(公告)日：2019-10-16

申请号：EP15175131.0

申请日：2009-05-13

Applicant: Array Biopharma, Inc.

Inventor： LE HUEROU, Yvan ,  BLAKE, James, F. ,  GUNWARDANA, Indrani, W. ,  MOHR, Peter, J. ,  WALLACE, Eli, M. ,  WANG, Bin ,  CHICARELLI, Mark ,  LYON, Michael

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

公开(公告)号：EP3089788B1

公开(公告)日：2018-10-24

申请号：EP14827985.4

申请日：2014-12-29

Applicant: Genentech, Inc. ,  Array Biopharma, Inc.

Inventor： BLAKE, James, F. ,  COOK, Adam ,  GUNAWARDANA, Indrani, W. ,  HUNT, Kevin, W. ,  LYON, Michael ,  METCALF, Andrew, T. ,  MOHR, Peter, J. ,  MORENO, David, A. ,  NEWHOUSE, Brad ,  REN, Li ,  TANG, Tony, P. ,  THOMAS, Allen, A. ,  SCHWARZ, Jacob ,  SCHMIDT, Jane ,  GAZZARD, Lewis ,  CHEN, Huifen

IPC: A61P35/00 ,  A61K31/506 ,  C07D401/14 ,  C07D405/14 ,  C07D403/04 ,  C07D403/14 ,  C07D417/14

CPC classification number: A61K31/506 ,  A61K31/4439 ,  A61K31/444 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04

Abstract: Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：EP3089788A1

公开(公告)日：2016-11-09

申请号：EP14827985.4

申请日：2014-12-29

Applicant: Genentech, Inc. ,  Array Biopharma, Inc.

Inventor： BLAKE, James, F. ,  COOK, Adam ,  GUNAWARDANA, Indrani, W. ,  HUNT, Kevin, W. ,  LYON, Michael ,  METCALF, Andrew, T. ,  MOHR, Peter, J. ,  MORENO, David, A. ,  NEWHOUSE, Brad ,  REN, Li ,  TANG, Tony, P. ,  THOMAS, Allen, A. ,  SCHWARZ, Jacob ,  SCHMIDT, Jane ,  GAZZARD, Lewis ,  CHEN, Huifen

IPC: A61P35/00 ,  A61K31/506 ,  C07D401/14 ,  C07D405/14 ,  C07D403/04 ,  C07D403/14 ,  C07D417/14

CPC classification number: A61K31/506 ,  A61K31/4439 ,  A61K31/444 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04

Abstract: Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 提供式I化合物或其立体异构体，互变异构体或药学上可接受的盐，其可用于治疗过度增殖性疼痛和炎性疾病。 公开了使用式I化合物或其立体异构体，互变异构体或药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞中的此类病症或相关病理学病症的方法。