公开(公告)号：WO2017062774A1

公开(公告)日：2017-04-13

申请号：PCT/US2016/055999

申请日：2016-10-07

Applicant: BAE SYSTEMS INFORMATION AND ELECTRONIC SYSTEMS INTEGRATION INC.

Inventor： MEDBERRY, John ,  DUBE, Mark J. ,  GRIGSBY, Will R. ,  JOHNSON, John D. ,  MCGAUGHEY, Joseph S. ,  NORD, Mitchell J. ,  BRANNAN, Gaylan L. ,  MATHUR, Somit S.

IPC: A61B3/14

CPC classification number: A61B3/11

Abstract: The system and method of pupil size independent pupillometry used for assessing critical diagnostic characteristics relating to neurotransmission and neuroactivity as applied to toxin exposure. The system and method utilizes the timing of a response to stimuli for a pupil of an individual, characterizes the timed responses, determines the latency of the timed responses, measures the minimum constriction value for the timed responses; and assesses the timed responses collected to diagnose changes in neurotransmission and neuroactivity for an individual exposed to organophosphate (OP) nerve agents or botulinum toxin (BTX).

Abstract translation: 用于评估应用于毒素暴露的与神经传递和神经活性有关的关键诊断特征的瞳孔大小独立瞳孔测量系统和方法。 系统和方法利用对个体瞳孔的刺激响应的定时，表征定时响应，确定定时响应的等待时间，测量定时响应的最小收缩值; 并评估收集的定时反应，以诊断暴露于有机磷酸盐（OP）神经药物或肉毒杆菌毒素（BTX）的个体的神经传递和神经活性变化。

公开(公告)号：WO2017062777A1

公开(公告)日：2017-04-13

申请号：PCT/US2016/056003

申请日：2016-10-07

Applicant: BAE SYSTEMS INFORMATION AND ELECTRONIC SYSTEMS INTEGRATION INC.

Inventor： MEDBERRY, John ,  DUBE, Mark J. ,  GRIGSBY, Will R. ,  JOHNSON, John D. ,  MCGAUGHEY, Joseph S. ,  NORD, Mitchell J. ,  BRANNAN, Gaylan L. ,  MATHUR, Somit S.

IPC: A61B3/06 ,  A61B3/11 ,  A61B3/14

CPC classification number: A61B3/11

Abstract: The system and method of size independent pupillometry used for assessing critical diagnostic characteristics relating to traumatic brain injury (TBI). The system and method utilizes the timing of a response to a stimuli for one or more pupils of an individual, characterizes the one or more timed responses, determines the latency of the one or more timed responses, measures the minimum constriction value for the one or more timed responses; and assesses the one or more timed responses collected to detect changes in neurotransmission and neuroactivity of an individual to assess the presence of a traumatic brain injury.

Abstract translation: 用于评估与创伤性脑损伤（TBI）相关的关键诊断特征的尺寸独立测微法的系统和方法。 系统和方法利用对个体的一个或多个瞳孔的刺激的响应的定时，表征一个或多个定时响应，确定一个或多个定时响应的等待时间，测量一个或多个定时响应的最小收缩值 更时间的回应; 并评估收集的一个或多个定时反应以检测个体的神经传递和神经活性的变化以评估创伤性脑损伤的存在。