公开(公告)号：DE4025330A1

公开(公告)日：1992-02-13

申请号：DE4025330

申请日：1990-08-09

Applicant: BASF AG

Inventor： SCHMIDT RICHARD R PROF DR ,  BAER THOMAS ,  SANDHOFF KONRAD PROF DR

IPC: C07C215/24 ,  C07D203/10 ,  C07D295/125 ,  C07H15/10

Abstract: Lipid derivs. of formula (I) are new. In (I) R1, R2 = H or Me; Y = H or an 8-22C acyl gp. opt. cong. 1-6 C=C double bonds; Z = OH, Me, SR3, N-pyrrolidinyl, N-piperidinyl, N-morpholinyl, 1-piperazinyl or N-thiomorpholinyl; or Y+Z = a bond; R3 = mono-or disaccharide; R4, R5=H or 1-4C alkyl; with the proviso that one of R1 and R2 is Me when Z is OH. Pref. R1 or R2 = Me; Y = H or satd. 13-22C acyl; Z=SR3 or NR4R5; or Y+Z=bond. USE - (I) are sphingolipid derivsl which are modulators and inhibitors of enzymatic glycosphingolipid biosynthesis, and may be inhibitors of protein kinase C. They may be used as modulators of intencellular communication and are thus important in treatment of oncological symptoms by controlling differentiation and proliferation of malignant cells. (I) may also be used as coagulation regulators and in modulation of immune reactions. (I) may be administered orally, buecally, parenterally or topically. Administration is 1-00mg/kg/day for system use. The use of (I) in the prepn. of non-natural glycosphingolipids is claimed.