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    2.
    发明专利
    未知

    公开(公告)号：DE3008522A1

    公开(公告)日：1981-09-17

    申请号：DE3008522

    申请日：1980-03-06

    Applicant: BASF AG

    Inventor： BOELL WALTER DIPL CHEM DR

    IPC: A61K31/435 ,  A61K31/445 ,  A61K31/535 ,  A61P9/06 ,  C07D221/00 ,  C07D307/00 ,  C07D491/04 ,  C07D491/048

    Abstract: 4- alpha -Amino-arylmethyl-6-methyl-1,3-dihydro-furo[3,4-c]pyridin-7-ols of the formula where R1 and R2 together are alkylene which may be interrupted by a hetero-atom and may be substituted by C1-4-alkyl, and R3 and R4 are hydrogen, hydroxyl, C1-3-alkyl, C1-3-alkoxy or halogen, processes for their preparation, and their use for the preparation of pyridinyl aminoalkyl ethers.

    3.
    发明专利
    未知

    公开(公告)号：DE2931672A1

    公开(公告)日：1981-02-26

    申请号：DE2931672

    申请日：1979-08-04

    Applicant: BASF AG

    Inventor： SCHWARZ GERD-ULRICH DIPL CHEM ,  KIEHS KARL DIPL CHEM DR ,  BOELL WALTER DIPL CHEM DR ,  ADOLPHI HEINRICH

    IPC: A01N43/12 ,  A01N53/00 ,  A01N53/04 ,  A01N57/00 ,  C07C69/743 ,  C07D307/79 ,  C07D307/82 ,  A01N43/08

    Abstract: Substituted 2,3-dihydrobenzofurylmethyl esters of the formula I I where where R8 is hydrogen or alkyl of up to 5 carbon atoms, R9 is alkyl, haloalkenyl or haloalkynyl, each of up to 5 carbon atoms, R10 is halogen or alkyl of up to 5 carbon atoms, R11 is halogen or alkyl of up to 5 carbon atoms, A is halogen, alkyl, alkoxy, trihaloalkyl or trihaloalkoxy, each of up to 5 carbon atoms, cyano or nitro, B is alkyl, alkenyl or alkynyl, each of up to 4 carbon atoms, or an alicyclic radical of 3 to 7 carbon atoms and n is from 0 to 3, R2 is hydrogen, cyano or alkyl, alkenyl or alkynyl, each of up to 5 carbon atoms, and R3, R4, R5, R6 and R7 are identical or different and each is hydrogen, halogen or alkyl, alkenyl, alkynyl or alkoxy, each of up to 5 carbon atoms, and R9 may also be alkenyl of up to 5 carbon atoms if R2 is cyano or is alkyl, alkenyl or alkynyl, each of up to 5 carbon atoms. The novel compounds are useful in pest control.

    4.
    发明专利
    未知

    公开(公告)号：DE2451725A1

    公开(公告)日：1976-05-13

    申请号：DE2451725

    申请日：1974-10-31

    Applicant: BASF AG

    Inventor： KOENIG HORST DIPL CHEM DR ,  BOELL WALTER DIPL CHEM DR

    IPC: C07D263/32

    Abstract: 4-Methyloxazole is manufactured by reaction of formimido-esters with hydroxyacetone. 4-Methyloxazole, manufactured by the process of the invention, is a starting material for the manufacture of dyes, pharmaceuticals, pesticides and vitamins.

    Diastereomeric 4,4-di:substd.-2-imidazolin-5-one derivs. - prepd. by asymmetric induction, intermediates for optically pure aminoacid(s) such as methyl-DOPA
    7.
    发明专利
    Diastereomeric 4,4-di:substd.-2-imidazolin-5-one derivs. - prepd. by asymmetric induction, intermediates for optically pure aminoacid(s) such as methyl-DOPA 未知

    公开(公告)号：DE2658941A1

    公开(公告)日：1978-07-06

    申请号：DE2658941

    申请日：1976-12-24

    Applicant: BASF AG

    Inventor： BOELL WALTER DIPL CHEM DR ,  KOENIG HORST DIPL CHEM DR ,  SCHOELLKOPF ULRICH PROF DIPL C ,  HAUSBERG HANS-HEINRICH DIPL CH

    IPC: C07D233/70 ,  C07C101/08 ,  C07C99/00

    Abstract: Imidazoline-5-one derivs. of formula (I) are new: R1 is the optical active residue of a primary amine or aminoacid. R2 is H, 1-4C alkyl, benzyl or phenyl. R3 is 1-4C alkyl (opt. substd. by alkoxy, alkylthio or dialkyamino (all 1-4C alkyl), benzyloxy, benzylthio, 1-4C acyloxy, CN, 2-5C carbalkoxy, benzoyl or phenyl (the rings opt. substd. by 103 halo, NO2, 1-4C alkyl, alkoxy, or alkylthio, benzyloxy, 1-4C acyloxy or acylamino, or by one phenoxy (itself opt. substd by 1-4C alkoxy or acyloxy), CF3 or methylenedioxy), or R3 is allyl or phenyl. R4 is 1-6C alkyl opt. substd. by alkoxy, alkylthio or dialkylamino (all 1-4C alkyl), piperidino, pyrrolidino, benzyloxy, benzylthio, CN, 2-5C carbalkoxy, benzoyl or phenyl (both opt. substd. as for corresp. gps. R3), or R4 is ClCH2 or allyl. Q is pyridyl, furyl, thienyl, naphthyl, benzothienyl or bromobenzofuran. Where R3 and R4 are different, (I) are intermediates (by conventional hydrolysis) for optically active alpha-e ethyl-arylalanines, e.g. alpha-methyl-dopa (an antihypertensive) and alpha-methyltyrosine (a tranquilliser). (I) are prepd. by alkylation of corresp. cpds. (I) where R4 is H alkylation at the 4-posn. proceeds with nearly 100% asymmetric induction (the nature of R1 determines the configuration at this position) and practically no O-alkylation occurs. In an example, 1-L-alpha-phenylethyl-4-methyl-4-benzyl-2-imidazoline-5-one was prepd. from the L-alpha-phenylethylamide of alpha-isocyanopropionic acid/n-BuLi and benzyl bromide.

    L-Alpha-methyl-DOPA from its DL-N-formyl deriv - by racemate separation with quinine and hydrolysis of the product
    8.
    发明专利
    L-Alpha-methyl-DOPA from its DL-N-formyl deriv - by racemate separation with quinine and hydrolysis of the product 未知

    公开(公告)号：DE2406898A1

    公开(公告)日：1975-09-04

    申请号：DE2406898

    申请日：1974-02-14

    Applicant: BASF AG

    Inventor： KOENIG HORST DIPL CHEM DR ,  BOELL WALTER DIPL CHEM DR

    IPC: C07D263/16 ,  C07C101/72

    Abstract: L-alpha-methyl-DOPA (I) is prepd. by (a) reacting DL-N-formyl-alpha-methyl-beta-(3,4-dimethoxyphenyl)alanine (II) with quinine in a polar organic solvent to form the crystalline diastereomeric (L(+)-N-formyl-alpha-methyl-beta-(3,4-dimethoxyphenyl)alanine quinine salt (III); (b) separating the crystalline (III); (c) cleaning the salt (III), separating the quinine, and precipitating L(+)-N-formyl-alpha-methyl-beta-(3,4-dimethoxyphenyl)alanine (IV) from aq. alkaline soln. by adding acid; and (d) saponifying (IV). The product (I) is obtained in high yields and high optical purity; the diastereomeric salt (III) is obtained in pure form without recrystallisation (practically quantitative yields) and can be converted into (IV) in a yield of >90%; (II) does not undergo premature hydrolysis during the treatment.

    Alkyl diazoacetate prepn. by diazotising alkyl glycine esters - in aq. soln. at acid pH in presence of extractor solvent
    9.
    发明专利
    Alkyl diazoacetate prepn. by diazotising alkyl glycine esters - in aq. soln. at acid pH in presence of extractor solvent 未知

    公开(公告)号：DE2400188A1

    公开(公告)日：1975-07-17

    申请号：DE2400188

    申请日：1974-01-03

    Applicant: BASF AG

    Inventor： NURRENBACH AXEL DIPL CHEM DR ,  BOELL WALTER DIPL CHEM DR

    IPC: C07C245/18 ,  C07C113/00

    Abstract: Alkyl diazoacetate (I) prepn. by diazotising acid salts of alkyl glycine esters in aq. so C: with an alkali metal nitrite in the presence of a water-immiscible organic solvent for ester of (I) formed, takes place at pH 4-5.5 (4.5-5). Pref. pH is kept near upper range at start of reaction and lowered to near bottom-end during reaction. (I) are intermediates for prepn. of insecticides, esp. chrysanthemum acid esters. Process may be carried out continuously; it is safe and decompsn. of (I) is prevented; temps. need not be kept below room temp; (I) may be extd. with solvent in which it is prepd. pH may be set with inorganic acids, esp. in dilute aq. solns., using 2-10 mol.% acid w.r.t. alkyl glycine esters. Temps. are esp. room temp. to 35 degrees C.

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