公开(公告)号：ES2243970T3

公开(公告)日：2005-12-01

申请号：ES97306380

申请日：1997-08-21

Applicant: BASF AG

Inventor： KNELL MARCUS ,  BRINK MONIKA

IPC: C07D213/78 ,  B01J27/08 ,  B01J27/10 ,  C07B61/00 ,  C07C51/00 ,  C07C51/58 ,  C07C51/62 ,  C07C241/00 ,  C07C243/26 ,  C07D20060101 ,  C07D213/127 ,  C07D213/26 ,  C07D213/46 ,  C07D213/61 ,  C07D213/79 ,  C07D213/81 ,  C07D237/24 ,  C07D239/28 ,  C07D241/24 ,  C07D249/04 ,  C07D249/10 ,  C07D251/26 ,  C07D257/08 ,  C07D259/00 ,  C07D261/08 ,  C07D401/12 ,  C07D401/14

Abstract: LA INVENCION SE REFIERE A UN PROCEDIMIENTO EFECTIVO Y EFICIENTE PARA LA PREPARACION COMPUESTOS DE TIPO CLORURO DE ACIDO AZINILICO DE LA FORMULA I, EN DONDE AZ REPRESENTA UN GRUPO AZINILO OPCIONALMENTE SUSTITUIDO, QUE COMPRENDE CALENTAR UNA TRICLOROMETILAZINA DE FORMULA II, EN DONDE AZ TIENE EL SIGNIFICADO DESCRITO, CON UN ACIDO, QUE FORMA UN CLORURO DE ACIDO, EL CUAL PUEDE SER DESTILADO BAJO PRESION REDUCIDA DURANTE LA REACCION, EN PRESENCIA DE UN CATALIZADOR ACIDO; Y A LA UTILIZACION DE LOS COMPUESTOS DE FORMULA I OBTENIDOS SEGUN ESTE PROCEDIMIENTO PARA LA PREPARACION DE (HETERO)ARILOXIAZINILCARBOXAMIDAS DE FORMULA VI, EN DONDE AZ TIENE EL SIGNIFICADO DESCRITO EN CUALQUIERA DE LAS REIVINDICACIONES ANTERIORES, Y AR REPRESENTA UN GRUPO ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDO, R SUP,3} REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO, Y R SUP,4} REPRESENTA UN GRUPO ALQUILO, ARILO, HETEROARILO O CICLOALQUILO OPCIONALMENTE SUSTITUIDO.

公开(公告)号：DE69733521T2

公开(公告)日：2005-11-03

申请号：DE69733521

申请日：1997-08-21

Applicant: BASF AG

Inventor： KNELL MARCUS ,  BRINK MONIKA

IPC: C07D213/78 ,  B01J27/08 ,  B01J27/10 ,  C07B61/00 ,  C07C51/00 ,  C07C51/58 ,  C07C51/62 ,  C07C241/00 ,  C07C243/26 ,  C07D20060101 ,  C07D213/127 ,  C07D213/26 ,  C07D213/46 ,  C07D213/61 ,  C07D213/79 ,  C07D213/81 ,  C07D237/24 ,  C07D239/28 ,  C07D241/24 ,  C07D249/04 ,  C07D249/10 ,  C07D251/26 ,  C07D257/08 ,  C07D259/00 ,  C07D261/08 ,  C07D401/12 ,  C07D401/14

Abstract: The invention relates to an effective and efficient process for the preparation of azinyl acid chloride compounds of formula I, wherein Az represents an optionally substituted azinyl group, which comprises heating a trichloromethylazine of formula II Az-CCl3 wherein Az has the meaning given, with an acid, that forms an acid chloride, which can be distilled off during the reaction under reduced pressure, in the presence of an acidic catalyst; and to the use of the compounds of formula I obtained according to this process for the preparation of (hetero)aryloxyazinylcarboxamides of formula VI in which Az has the meaning given in any of the preceding claims, and Ar represents an optionally substituted aryl or heteroaryl group, R represents a hydrogen atom or an alkyl group, and R represents an optionally substituted alkyl, aryl, heteroaryl or cycloalkyl group.

公开(公告)号：DE69733521D1

公开(公告)日：2005-07-21

申请号：DE69733521

申请日：1997-08-21

Applicant: BASF AG

Inventor： KNELL MARCUS ,  BRINK MONIKA

IPC: C07D213/78 ,  B01J27/08 ,  B01J27/10 ,  C07B61/00 ,  C07C51/00 ,  C07C51/58 ,  C07C51/62 ,  C07C241/00 ,  C07C243/26 ,  C07D20060101 ,  C07D213/127 ,  C07D213/26 ,  C07D213/46 ,  C07D213/61 ,  C07D213/79 ,  C07D213/81 ,  C07D237/24 ,  C07D239/28 ,  C07D241/24 ,  C07D249/04 ,  C07D249/10 ,  C07D251/26 ,  C07D257/08 ,  C07D259/00 ,  C07D261/08 ,  C07D401/12 ,  C07D401/14

Abstract: The invention relates to an effective and efficient process for the preparation of azinyl acid chloride compounds of formula I, wherein Az represents an optionally substituted azinyl group, which comprises heating a trichloromethylazine of formula II Az-CCl3 wherein Az has the meaning given, with an acid, that forms an acid chloride, which can be distilled off during the reaction under reduced pressure, in the presence of an acidic catalyst; and to the use of the compounds of formula I obtained according to this process for the preparation of (hetero)aryloxyazinylcarboxamides of formula VI in which Az has the meaning given in any of the preceding claims, and Ar represents an optionally substituted aryl or heteroaryl group, R represents a hydrogen atom or an alkyl group, and R represents an optionally substituted alkyl, aryl, heteroaryl or cycloalkyl group.

公开(公告)号：DE69801168T2

公开(公告)日：2002-03-28

申请号：DE69801168

申请日：1998-01-13

Applicant: BASF AG

Inventor： VAN DEN AKKER LAURENS WILHEM ,  BRINK MONIKA

IPC: B01J27/128 ,  C07B61/00 ,  C07C45/46 ,  C07C49/80 ,  C07C49/807 ,  C07C49/813 ,  C07C49/84 ,  C07C51/58 ,  C07C63/68 ,  C07C63/70

公开(公告)号：CA2626465A1

公开(公告)日：2007-05-10

申请号：CA2626465

申请日：2006-10-26

Applicant: BASF AG

Inventor： WEVERS JAN HENDRIK ,  BRINK MONIKA ,  KNELL MARCUS

IPC: C07D213/81 ,  C07D213/79

Abstract: The invention relates to a process for the preparation of pyridylcarboxylic amides and esters I, Formula (I) wherein Hal, X and R1 have the meanings given in claim 1, which comprises the following steps: (a) heating a mixture consisting essentially of trichloromethylpyridine II, Formula (II), wherein Hal has the meaning given, and 1.0 to 1.5 equivalents of concentrated sulfuric acid, characterized in that the trichloromethylpyridine II in a liquid form is added to the concentrated sulfuric acid at a temperature from 110° C. to 160° C.; and (b) reacting the intermediate product obtained in step (a) with an amine or alcohol III, HXR1, wherein X and R1 have the meaning given, optionally in the presence of a solvent and/or a base.

公开(公告)号：PT899262E

公开(公告)日：2005-08-31

申请号：PT98306530

申请日：1998-08-17

Applicant: BASF AG

Inventor： KNELL MARCUS ,  WEVERS JAN HENDRIK ,  BRINK MONIKA ,  WILLI HEINZ

IPC: C07D213/79 ,  C07D20060101 ,  C07D213/00 ,  C07D213/02 ,  C07D213/04 ,  C07D213/60 ,  C07D213/78 ,  C07D213/80 ,  C07D213/803 ,  C07D213/81 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D403/00

公开(公告)号：AT297896T

公开(公告)日：2005-07-15

申请号：AT97306380

申请日：1997-08-21

Applicant: BASF AG

Inventor： KNELL MARCUS ,  BRINK MONIKA

IPC: C07D213/78 ,  B01J27/08 ,  B01J27/10 ,  C07B61/00 ,  C07C51/00 ,  C07C51/58 ,  C07C51/62 ,  C07C241/00 ,  C07C243/26 ,  C07D20060101 ,  C07D213/127 ,  C07D213/26 ,  C07D213/46 ,  C07D213/61 ,  C07D213/79 ,  C07D213/81 ,  C07D237/24 ,  C07D239/28 ,  C07D241/24 ,  C07D249/04 ,  C07D249/10 ,  C07D251/26 ,  C07D257/08 ,  C07D259/00 ,  C07D261/08 ,  C07D401/12 ,  C07D401/14

Abstract: The invention relates to an effective and efficient process for the preparation of azinyl acid chloride compounds of formula I, wherein Az represents an optionally substituted azinyl group, which comprises heating a trichloromethylazine of formula II Az-CCl3 wherein Az has the meaning given, with an acid, that forms an acid chloride, which can be distilled off during the reaction under reduced pressure, in the presence of an acidic catalyst; and to the use of the compounds of formula I obtained according to this process for the preparation of (hetero)aryloxyazinylcarboxamides of formula VI in which Az has the meaning given in any of the preceding claims, and Ar represents an optionally substituted aryl or heteroaryl group, R represents a hydrogen atom or an alkyl group, and R represents an optionally substituted alkyl, aryl, heteroaryl or cycloalkyl group.

公开(公告)号：AT292624T

公开(公告)日：2005-04-15

申请号：AT98306530

申请日：1998-08-17

Applicant: BASF AG

Inventor： KNELL MARCUS ,  BRINK MONIKA ,  WEVERS JAN HENDRIK ,  HEINZ WILLI

IPC: C07D213/79 ,  C07D20060101 ,  C07D213/00 ,  C07D213/02 ,  C07D213/04 ,  C07D213/60 ,  C07D213/78 ,  C07D213/80 ,  C07D213/803 ,  C07D213/81 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D403/00

Abstract: The invention relates to a process for the preparation of heteroarylcarboxylic amides and esters of formula I in which A through A , R , Hal and X one or two of the groups A , A , A , A and A represent a nitrogen atom and the other groups each independently represent CR , Hal represents a halogen atom, X represents oxygen or NR , R1 represents an optionally substituted alkyl, aryl, heteroaryl or cycloalkyl group, R represents a hydrogen atom or an alkyl group, or R and R together with the interjacent ring form a heterocyclic group, and R each independently represent a hydrogen atom or an alkyl group, which comprises: heating a mixture consisting essentially of heteroaryltrichloromethane compound of formula II, in which A through A and Hal are as hereinbefore defined, and 1.0 to 1.5 equivalents of concentrated sulfuric acid, and reacting the resulting intermediate product with an alcohol or amine of formula III HXR optionally in the presence of a diluent and/or a base.

公开(公告)号：SI0899262T1

公开(公告)日：2005-10-31

申请号：SI9830776

申请日：1998-08-17

Applicant: BASF AG

Inventor： KNELL MARCUS ,  BRINK MONIKA ,  WEVERS JAN HENDRIK ,  HEINZ WILLI

IPC: C07D213/79 ,  C07D20060101 ,  C07D213/00 ,  C07D213/02 ,  C07D213/04 ,  C07D213/60 ,  C07D213/78 ,  C07D213/80 ,  C07D213/803 ,  C07D213/81 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D403/00

Abstract: The invention relates to a process for the preparation of heteroarylcarboxylic amides and esters of formula I in which A through A , R , Hal and X one or two of the groups A , A , A , A and A represent a nitrogen atom and the other groups each independently represent CR , Hal represents a halogen atom, X represents oxygen or NR , R1 represents an optionally substituted alkyl, aryl, heteroaryl or cycloalkyl group, R represents a hydrogen atom or an alkyl group, or R and R together with the interjacent ring form a heterocyclic group, and R each independently represent a hydrogen atom or an alkyl group, which comprises: heating a mixture consisting essentially of heteroaryltrichloromethane compound of formula II, in which A through A and Hal are as hereinbefore defined, and 1.0 to 1.5 equivalents of concentrated sulfuric acid, and reacting the resulting intermediate product with an alcohol or amine of formula III HXR optionally in the presence of a diluent and/or a base.

公开(公告)号：ES2241102T3

公开(公告)日：2005-10-16

申请号：ES98306530

申请日：1998-08-17

Applicant: BASF AG

Inventor： KNELL MARCUS ,  BRINK MONIKA ,  WEVERS JAN HENDRIK ,  HEINZ WILLI

IPC: C07D213/79 ,  C07D20060101 ,  C07D213/00 ,  C07D213/02 ,  C07D213/04 ,  C07D213/60 ,  C07D213/78 ,  C07D213/80 ,  C07D213/803 ,  C07D213/81 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D403/00

Abstract: LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE AMIDAS Y ESTERES HETEROARILCARBOXILICOS DE FORMULA I: DONDE DESDE A 1 HASTA A 5 , R 1 , HAL Y X REPRESENTAN: UNO O DOS DE LOS GRUPOS ENTRE A 1 , A 2 , A SUP,3 , A 4 Y A 5 REPRESENTAN UN ATOMO DE NITROGENO Y LOS DEMAS GRUPOS, CADA UNO INDEPENDIENTEMENTE, REPRESENTAN CR 3 , HAL REPRESENTA UN ATOMO DE HALOGENO, X REPRESENTA OX IGENO O NR 2 , R 1 REPRESENTA UN GRUPO CICLOALQUILO, HETEROARILO, ARILO O ALQUILO, OPCIONALMENTE SUSTITUIDO, R 2 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO, O R SUP,1 Y R 2 FORMAN CONJUNTAMENTE CON EL CICLO INTERYACENTE, UN GRUPO HETEROCICLICO, Y R 3 CADA UNO INDEPENDIENTEMENTE, REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO, DICHO PROCEDIMIENTO CONSISTE EN CALENTAR LA MEZCLA, COMPUESTA FUNDAMENTALMENTE POR UN COMPUESTO HETEROARILTRICLOROMETANO DE FORMULA II: EN LA QUE DE A 1 A A 5 Y HAL, SON TAL Y COMO SE LOS DESCRIBIO ANTERIORMENTE, Y DE 1,0 A 1,5 EQUIVALENTES DE ACIDO SULFURICO CONCENTRADO, Y HACIENDO REACCIONAR EL PRODUCTO INTERMEDIO RESULTANTE CON UN ALCOHOL O AMINA DE FORMULA III: OPCIONALMENTE EN PRESENCIA DE UN DILUYENTE Y/O UNA BASE.