公开(公告)号：DK1083884T3

公开(公告)日：2002-11-04

申请号：DK00917004

申请日：2000-03-28

Applicant: BASF AG

Inventor： BUEHLER VOLKER ,  FILGES ULRICH ,  SCHNEIDER TANJA

IPC: A61K9/20 ,  A61K47/02 ,  A61K47/32 ,  A61K47/42 ,  A61K47/46 ,  C08J3/12 ,  C08J3/20 ,  C08K3/00 ,  C08K3/08 ,  C08L39/06

Abstract: Preparations in powder form comprising or consisting of soluble or insoluble polyvinylpyrrolidone and/or polyvinylpyrrolidone copolymers and suitable as aid for pharmaceutical formulations comprise in homogeneous dispersion very small amounts of heavy metals which are physiologically tolerated in these amounts, or very small amounts of peroxide-cleaving enzymes.

公开(公告)号：DE19915420A1

公开(公告)日：2000-10-12

申请号：DE19915420

申请日：1999-04-06

Applicant: BASF AG

Inventor： BUEHLER VOLKER ,  FILGES ULRICH ,  SCHNEIDER TANJA

IPC: A61K9/20 ,  A61K47/02 ,  A61K47/32 ,  A61K47/42 ,  A61K47/46 ,  C08J3/12 ,  C08J3/20 ,  C08K3/00 ,  C08K3/08 ,  C08L39/06 ,  A61K47/34

Abstract: The invention relates to powder formulations which contain or consist of soluble or insoluble polyvinylpyrrolidone and/or polyvinylpyrrolidone copolymers and which are suitable for use as auxiliary agents for formulations of medicaments. The inventive formulations contain very small, homogeneously distributed quantities of heavy metals that are physiologically compatible in these quantities or very small quantities of peroxide-splitting enzymes.

公开(公告)号：DK163172C

公开(公告)日：1992-06-22

申请号：DK602085

申请日：1985-12-23

Applicant: BASF AG

Inventor： BUEHLER VOLKER ,  HOFMANN FRIEDBERT ,  HEINZ ROBERT

IPC: A61K9/14 ,  A61K9/16 ,  A61K31/375 ,  B01J2/22

Abstract: Ascorbic acid granules for direct tableting are prepared by the compacting method, wherein the ascorbic acid in the form of crystals or crystal fragments, of which not more than 40% by weight have a longest particle diameter of less than 50 mu m and not more than 15% by weight have a longest particle diameter greater than 500 mu m, and as a mixture with from 0.8 to 8% by weight of soluble polyvinylpyrrolidone having a water content of from 0.3 to 5% is compacted in a conventional manner, and the product is comminuted.

公开(公告)号：HU195107B

公开(公告)日：1988-04-28

申请号：HU493785

申请日：1985-12-20

Applicant: BASF AG

Inventor： BUEHLER VOLKER ,  HOFMANN FRIEDBERT ,  HEINZ ROBERT

IPC: A61K9/14 ,  A61K9/16 ,  A61K31/375 ,  B01J2/22 ,  A61K31/70

Abstract: Ascorbic acid granules for direct tableting are prepared by the compacting method, wherein the ascorbic acid in the form of crystals or crystal fragments, of which not more than 40% by weight have a longest particle diameter of less than 50 mu m and not more than 15% by weight have a longest particle diameter greater than 500 mu m, and as a mixture with from 0.8 to 8% by weight of soluble polyvinylpyrrolidone having a water content of from 0.3 to 5% is compacted in a conventional manner, and the product is comminuted.

公开(公告)号：NO157204B

公开(公告)日：1987-11-02

申请号：NO821084

申请日：1982-03-31

Applicant: BASF AG

Inventor： EINIG HEINZ ,  BUEHLER VOLKER ,  KOCH WINFRIED ,  SCHWARZ JOACHIM ARTHUR

IPC: A61K9/18 ,  A61K9/22 ,  A61K9/24 ,  A61K9/52 ,  A61K9/54 ,  A61K31/275 ,  A61K31/277 ,  A61P3/00 ,  A61P3/14

公开(公告)号：AU579691B2

公开(公告)日：1988-12-08

申请号：AU5160185

申请日：1985-12-23

Applicant: BASF AG

Inventor： BUEHLER VOLKER ,  HOFMANN FRIEDBERT ,  HEINZ ROBERT

IPC: A61K9/14 ,  A61K9/16 ,  A61K31/375 ,  B01J2/22 ,  A61K31/34

Abstract: Ascorbic acid granules for direct tableting are prepared by the compacting method, wherein the ascorbic acid in the form of crystals or crystal fragments, of which not more than 40% by weight have a longest particle diameter of less than 50 mu m and not more than 15% by weight have a longest particle diameter greater than 500 mu m, and as a mixture with from 0.8 to 8% by weight of soluble polyvinylpyrrolidone having a water content of from 0.3 to 5% is compacted in a conventional manner, and the product is comminuted.

公开(公告)号：HUT40562A

公开(公告)日：1987-01-28

申请号：HU493785

申请日：1985-12-20

Applicant: BASF AG

Inventor： BUEHLER VOLKER ,  HOFMANN FRIEDBERT ,  HEINZ ROBERT

IPC: A61K9/14 ,  A61K9/16 ,  A61K31/375 ,  B01J2/22 ,  A61K31/70

Abstract: Ascorbic acid granules for direct tableting are prepared by the compacting method, wherein the ascorbic acid in the form of crystals or crystal fragments, of which not more than 40% by weight have a longest particle diameter of less than 50 mu m and not more than 15% by weight have a longest particle diameter greater than 500 mu m, and as a mixture with from 0.8 to 8% by weight of soluble polyvinylpyrrolidone having a water content of from 0.3 to 5% is compacted in a conventional manner, and the product is comminuted.

公开(公告)号：AU555093B2

公开(公告)日：1986-09-11

申请号：AU8238482

申请日：1982-04-06

Applicant: BASF AG

Inventor： EINIG HEINZ ,  BUEHLER VOLKER ,  KOCH WINFRIED ,  SCHWARZ JOACHIM ARTHUR

IPC: A61K9/18 ,  A61K9/22 ,  A61K9/24 ,  A61K9/52 ,  A61K9/54 ,  A61K31/275 ,  A61K31/277 ,  A61P3/00 ,  A61P3/14

公开(公告)号：DK602085D0

公开(公告)日：1985-12-23

申请号：DK602085

申请日：1985-12-23

Applicant: BASF AG

Inventor： BUEHLER VOLKER ,  HOFMANN FRIEDBERT ,  HEINZ ROBERT

IPC: A61K9/14 ,  A61K9/16 ,  A61K31/375 ,  B01J2/22 ,  A61K

Abstract: Ascorbic acid granules for direct tableting are prepared by the compacting method, wherein the ascorbic acid in the form of crystals or crystal fragments, of which not more than 40% by weight have a longest particle diameter of less than 50 mu m and not more than 15% by weight have a longest particle diameter greater than 500 mu m, and as a mixture with from 0.8 to 8% by weight of soluble polyvinylpyrrolidone having a water content of from 0.3 to 5% is compacted in a conventional manner, and the product is comminuted.

公开(公告)号：HU186855B

公开(公告)日：1985-10-28

申请号：HU105882

申请日：1982-04-06

Applicant: BASF AG

Inventor： EINIG HEINZ ,  BUEHLER VOLKER ,  KOCH WINFRIED ,  SCHWARZ JOACHIM A

IPC: A61K9/18 ,  A61K9/22 ,  A61K9/24 ,  A61K9/52 ,  A61K9/54 ,  A61K31/275 ,  A61K31/277 ,  A61P3/00 ,  A61P3/14 ,  C07C121/75