公开(公告)号：DE19707008A1

公开(公告)日：1998-08-27

申请号：DE19707008

申请日：1997-02-21

Applicant: BASF AG

Inventor： DINGLER CHRISTOPH DR ,  HOLMAN NICHOLAS JOHN DR

IPC: C12N9/02 ,  C07D487/04 ,  C12P17/18 ,  E03D7/00 ,  E04H1/12

Abstract: The invention relates to a method for producing enantiomer-free alcohols of formula (I) (Ia or Ib), in which the substituents represent the following; R represents hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, or C1-C6-alkanoyl-; R and R independently of each other represent hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, or C1-C6-alkanoyl-, C1-C6-alkylthio-, C1-C6-alkyl sulfinyl- or C1-C6-alkyl sulfonyl-; and R is a substituted or unsubstituted C1-C6-alkyl-, C3-C6-cycloalkyl-. Said method is characterized in that compounds of formula (II), in which the substituents R to R have the meaning given above, are reduced to compounds of formula (I) in an aqueous solution, in the presence of a carbon source and a microorganism or a reducing agent and an enzyme.

公开(公告)号：DE4414548A1

公开(公告)日：1995-11-02

申请号：DE4414548

申请日：1994-04-26

Applicant: BASF AG

Inventor： DINGLER CHRISTOPH DR ,  LADNER WOLFGANG DR ,  KREI GEORG ARNOLD

IPC: C12P7/42 ,  C12P1/00 ,  C12P7/40 ,  C12P7/62 ,  C12R1/645 ,  C07C59/68

Abstract: A process for the biotransformation of carboxylic acids in the presence of a microorganism in which the best possible concentration of undissociated carboxylic acid for biotransformation is set by controlling the pH throughout the biotransformation process.