公开(公告)号：AU3669801A

公开(公告)日：2001-08-14

申请号：AU3669801

申请日：2001-02-06

Applicant: BASF AG

Inventor： CUSACK KEVIN P ,  SCOTT BARBARA ,  ARNOLD LEE D ,  ERICSSON ANNA

IPC: C07D295/12 ,  A61K31/428 ,  A61K31/429 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/496 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/69 ,  A61K31/695 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/06 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/14 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P25/04 ,  A61P25/28 ,  A61P27/02 ,  A61P27/10 ,  A61P29/00 ,  A61P31/04 ,  A61P31/18 ,  A61P31/20 ,  A61P31/22 ,  A61P33/02 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  A61P37/06 ,  A61P43/00 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D451/02 ,  C07D451/04 ,  C07D451/14 ,  C07D453/02 ,  C07D487/08 ,  C07D513/04 ,  C07D521/00 ,  A61K31/435

Abstract: The present invention is directed to a compound of formula (I), racemic-diastereomeric mixtures thereof, optical isomers thereof, prodrugs thereof, isotopes thereof or pharmaceutically-acceptable salts of said compound, isomers, prodrugs and isotopes, wherein the variables are defined herein. The compounds of this invention are useful as inhibitors of serine/threonine and tyrosine kinases. In particular, compounds of this invention are useful as inhibitors of tyrosine kinases that are important in hyperproliferative diseases, especially in cancer and in the process of angiogenesis.