公开(公告)号：ZA8006122B

公开(公告)日：1981-10-28

申请号：ZA8006122

申请日：1980-10-03

Applicant: BASF AG

Inventor： MOEBIUS L ,  OESER H ,  HICKMAN E

IPC: C07D401/06 ,  C07D209/38 ,  C07D215/50 ,  C07C

CPC classification number: C07D215/50 ,  C07D209/38

公开(公告)号：ZA806122B

公开(公告)日：1981-10-28

申请号：ZA806122

申请日：1980-10-03

Applicant: BASF AG

Inventor： MOEBIUS L ,  OESER H ,  HICKMAN E

IPC: A61K31/47 ,  C07D401/06 ,  C07D209/38 ,  C07D211/22 ,  C07D215/14 ,  C07D215/50 ,  C07C

Abstract: The present invention relates to a simplified process, which avoids organo-lithium intermediates, for the preparation of erythro- alpha -piperid-2-yl-2,8-bis-(trifluoromethyl)-quinolin-4-yl-methanol, wherein 2,8-bis-(trifluoromethyl)-quinoline-4-carboxylic acid or a salt thereof is reacted with a pyrid-2-yl-magnesium halide to give pyrid-2-yl-2,8-bis-(trifluoromethyl)-quinolin-4-yl ketone in the manner of a Grignard reaction, and this product is hydrogenated, in a conventional manner, to give erythro- alpha -piperid-2-yl-2,8-bis-(trifluoromethyl)-quinolin-4-yl-methanol.