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公开(公告)号：HU177936B
公开(公告)日：1982-02-28
申请号：HUBA003573
申请日：1977-08-19
Applicant: BASF AG
Inventor： HOFFMANN HERWING , GRAEFJE HEINZ , KOERING WOLFGANG , WINDERL SIEGFRIED
IPC: C07D295/084 , C07C91/14 , C07D295/04
Abstract: The manufacture of N-disubstituted 1-aminoalk-2-yn-4-ols by reacting a secondary amine, e.g. a dialkylamine, formaldehyde and an acetylene-alcohol by a Mannich reaction, using a copper catalyst, takes place with better yield and at a higher rate if carried out in the presence of iodine or of a bromide or iodide.
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