公开(公告)号：WO2006108663A8

公开(公告)日：2007-11-22

申请号：PCT/EP2006003431

申请日：2006-04-13

Applicant: BASF AG ,  HAN DUCK-KEUN ,  CHOI JONG-KYU ,  HONG IL-KWON ,  KIM HYUN-HO ,  CHOI JONG-SOO ,  KIM TAE-HUI ,  KIM SUNG HYUN

Inventor： HAN DUCK-KEUN ,  CHOI JONG-KYU ,  HONG IL-KWON ,  KIM HYUN-HO ,  CHOI JONG-SOO ,  KIM TAE-HUI ,  KIM SUNG HYUN

IPC: C12P13/04 ,  C07C227/40 ,  C07C229/02

CPC classification number: C12P13/04 ,  C07C227/40 ,  C07C229/26

Abstract: The invention relates to a method for recovering a basic amino acid from the fermentation liquor of a micro-organism strain that produces the basic amino acid. The method comprises the following steps: a) isolation of the micro-organisms from the fermentation liquor and b) separation of the basic amino acid from the aqueous liquor that has been obtained in step a) by the successive charging of a single or multiple stage arrangement of a strongly acidic cation exchanger in the form of a salt with the liquor obtained in step a) and the elution of the basic amino acid. According to the invention, prior to the charging process in step b), the aqueous liquor has a pH value ranging between 4 and 7.5 and at least the first stage of the cation exchanger arrangement is pre-treated with an aqueous acid in such a way that at the end of said pre-treatment, the pH value at the discharge of the pre-treated cation exchanger ranges between 4.5 and 7.

Abstract translation: 本发明涉及一种用于从该碱性氨基酸的微生物菌株的发酵肉汤获得的碱性氨基酸的方法。 该方法包括以下步骤：a）将来自发酵培养液中的微生物，以及b）通过强酸性阳离子交换剂与在其盐形式的单步或多步排列的连续装载从在步骤a）得到的含水肉汤碱性氨基酸中分离 步骤a）保护者请求肉汤和碱性氨基酸，其特征在于，装载前的水性培养液包含在步骤b）具有范围从4至7.5和至少以这样的方式用含水酸阳离子交换的第一阶段的pH值洗脱 进行预处理，使得在预处理结束时pH值在经预处理的阳离子交换剂的端部是在从4.5到7位于的范围内。

公开(公告)号：CA2604781A1

公开(公告)日：2006-10-19

申请号：CA2604781

申请日：2006-04-13

Applicant: BASF AG

Inventor： KIM TAE-HUI ,  CHOI JONG-SOO ,  KIM HYUN-HO ,  HONG IL-KWON ,  HAN DUCK-KEUN ,  CHOI JONG-KYU ,  KIM SUNG HYUN

IPC: C12P13/04 ,  C07C227/40 ,  C07C229/02

Abstract: The invention relates to a method for recovering a basic amino acid from the fermentation liquor of a micro-organism strain that produces the basic amino acid. The method comprises the following steps: a) isolation of the micro-organisms from the fermentation liquor and b) separation of the basic amino acid from the aqueous liquor that has been obtained in step a) by the successive charging of a single or multiple stage arrangement of a strongly acidic cation exchanger in the form of a salt with the liquor obtained in step a) and the elution of the basic amino acid. According to the invention, prior to the charging process in step b), the aqueous liquor has a pH value ranging between 4 and 7.5 and at least the first stage of the carbon exchanger arrangement is pre-treated with an aqueous acid in such a way that at the end of said pre-treatment, the pH value at the discharge of the pre-treated cation exchanger ranges between 4.5 and 7.

公开(公告)号：AU2006233710A1

公开(公告)日：2006-10-19

申请号：AU2006233710

申请日：2006-04-13

Applicant: BASF AG

Inventor： KIM TAE-HUI ,  CHOI JONG-SOO ,  KIM SUNG HYUN

IPC: C12P13/04 ,  C07C227/40 ,  C07C229/02

Abstract: The invention relates to a method for recovering a basic amino acid from the fermentation liquor of a micro-organism strain that produces the basic amino acid. According to said method: a) the fermentation liquor is acidified with an acid, whose pKs value in water at 25° C. ranges between 2 and 5; and b) the basic amino acid is separated from the aqueous liquor obtained in step a) by the successive charging of a single or multiple stage, serial arrangement of a strongly acidic cation exchanger in the form of a salt with the liquor that has been obtained in step a) and the subsequent elution of the basic amino acid using a basic eluant.

公开(公告)号：DE102005017508A1

公开(公告)日：2006-10-19

申请号：DE102005017508

申请日：2005-04-15

Applicant: BASF AG

Inventor： CHOI JONG-SOO ,  KIM TAE-HUI ,  KIM SUNG HYUN

IPC: C12P13/04 ,  C12P13/08 ,  C12P13/10

Abstract: The invention relates to a method for recovering a basic amino acid from the fermentation liquor of a micro-organism strain that produces the basic amino acid. According to said method: a) the fermentation liquor is acidified with an acid, whose pKs value in water at 25° C. ranges between 2 and 5; and b) the basic amino acid is separated from the aqueous liquor obtained in step a) by the successive charging of a single or multiple stage, serial arrangement of a strongly acidic cation exchanger in the form of a salt with the liquor that has been obtained in step a) and the subsequent elution of the basic amino acid using a basic eluant.

公开(公告)号：BRPI0609757A2

公开(公告)日：2011-10-18

申请号：BRPI0609757

申请日：2006-04-13

Applicant: BASF AG

Inventor： HAN DUCK-KEUN ,  CHOI JONG-KYU ,  HONG II-KWON ,  KIM HYUN-HO ,  CHOI JONG-SOO ,  KIM TAE-HUI ,  KIM SUNG HYUN

IPC: C12P13/04 ,  C07C227/40 ,  C07C229/02

Abstract: The invention relates to a method for recovering a basic amino acid from the fermentation liquor of a micro-organism strain that produces the basic amino acid. The method comprises the following steps: a) isolation of the micro-organisms from the fermentation liquor and b) separation of the basic amino acid from the aqueous liquor that has been obtained in step a) by the successive charging of a single or multiple stage arrangement of a strongly acidic cation exchanger in the form of a salt with the liquor obtained in step a) and the elution of the basic amino acid. According to the invention, prior to the charging process in step b), the aqueous liquor has a pH value ranging between 4 and 7.5 and at least the first stage of the carbon exchanger arrangement is pre-treated with an aqueous acid in such a way that at the end of said pre-treatment, the pH value at the discharge of the pre-treated cation exchanger ranges between 4.5 and 7.

公开(公告)号：BRPI0609756A2

公开(公告)日：2011-10-18

申请号：BRPI0609756

申请日：2006-04-13

Applicant: BASF AG

Inventor： CHOI JONG-SOO ,  KIM TAE-HUI ,  KIM SUNG HYUN

IPC: C12P13/04 ,  C07C227/40 ,  C07C229/02

Abstract: The invention relates to a method for recovering a basic amino acid from the fermentation liquor of a micro-organism strain that produces the basic amino acid. According to said method: a) the fermentation liquor is acidified with an acid, whose pKs value in water at 25° C. ranges between 2 and 5; and b) the basic amino acid is separated from the aqueous liquor obtained in step a) by the successive charging of a single or multiple stage, serial arrangement of a strongly acidic cation exchanger in the form of a salt with the liquor that has been obtained in step a) and the subsequent elution of the basic amino acid using a basic eluant.

公开(公告)号：CA2604556A1

公开(公告)日：2006-10-19

申请号：CA2604556

申请日：2006-04-13

Applicant: BASF AG

Inventor： CHOI JONG-SOO ,  KIM SUNG HYUN ,  KIM TAE-HUI

IPC: C12P13/04 ,  C07C227/40 ,  C07C229/02

Abstract: The invention relates to a method for recovering a basic amino acid from the fermentation liquor of a micro-organism strain that produces the basic amino acid. According to said method: a) the fermentation liquor is acidified with an acid, whose pKs value in water at 25 ~C ranges between 2 and 5; and b) th e basic amino acid is separated from the aqueous liquor obtained in step a) by the successive charging of a single or multiple stage, serial arrangement of a strongly acidic cation exchanger in the form of a salt with the liquor that has been obtained in step a) and the subsequent elution of the basic amino acid using a basic eluant.

公开(公告)号：AU2006233711A1

公开(公告)日：2006-10-19

申请号：AU2006233711

申请日：2006-04-13

Applicant: BASF AG

Inventor： KIM SUNG HYUN ,  KIM HYUN-HO ,  HONG IL-KWON ,  KIM TAE-HUI ,  CHOI JONG-SOO ,  HAN DUCK-KEUN ,  CHOI JONG-KYU

IPC: C12P13/04 ,  C07C227/40 ,  C07C229/02

Abstract: The invention relates to a method for recovering a basic amino acid from the fermentation liquor of a micro-organism strain that produces the basic amino acid. The method comprises the following steps: a) isolation of the micro-organisms from the fermentation liquor and b) separation of the basic amino acid from the aqueous liquor that has been obtained in step a) by the successive charging of a single or multiple stage arrangement of a strongly acidic cation exchanger in the form of a salt with the liquor obtained in step a) and the elution of the basic amino acid. According to the invention, prior to the charging process in step b), the aqueous liquor has a pH value ranging between 4 and 7.5 and at least the first stage of the carbon exchanger arrangement is pre-treated with an aqueous acid in such a way that at the end of said pre-treatment, the pH value at the discharge of the pre-treated cation exchanger ranges between 4.5 and 7.