公开(公告)号：JPH1087632A

公开(公告)日：1998-04-07

申请号：JP22248497

申请日：1997-08-19

Applicant: BASF AG

Inventor： HIEBER GISELA DR ,  EBEL KLAUS DR ,  SCHROEDER JUERGEN DR ,  DOCKNER TONI DR ,  GROENING CARSTEN DR ,  RUGE BERND DR

IPC: C07D233/58 ,  B01J21/12 ,  B01J27/16 ,  C07D233/54 ,  C07D233/68 ,  C07D233/90 ,  C07D233/91 ,  C07D233/92 ,  C07D235/06 ,  C07D235/08

Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound useful as a precursor substance or an intermediate for producing dyestuffs, fiber auxiliaries, plastics, etc., by directly using an aqueous imidazole phase obtained on the synthesis of the substituted imidazole. SOLUTION: The aqueous phase of an imidazole compound of formula I (R , R , R are each H, a halogen, NO2 , etc.) is reacted with a compound of the formula: R -O-R (R is a 1-20C hydrocarbon; R is H or R ) in the presence of a catalyst such as the oxide of a metal belonging to the subgroup 4 in the main groups 2, 3, 4 in the periodic table, a phosphate salt, etc., at 220-550 deg.C to produce the substituted imidazole of formula II. The catalyst is used in the form of a fixed bed, and an advantageous catalyst comprises 40-99wt.% of SiO2 and 1-60wt.% of H3 PO4 , or comprises 70-90wt.% of Al2 O3 and 10-30wt.% of SiO2 . Water and the compound of formula I are used in amounts of 99.9-0.1wt.% and 0.1-99.9wt.%, especially advantageously 40-10wt.% and 60-90wt.%, respectively, in the reaction. The reaction temperature is 200-550 deg.C, especially advantageously 280-420 deg.C.

公开(公告)号：DE19633390A1

公开(公告)日：1998-02-26

申请号：DE19633390

申请日：1996-08-19

Applicant: BASF AG

Inventor： HIEBER GISELA DR ,  EBEL KLAUS DR ,  SCHROEDER JUERGEN DR ,  DOCKNER TONI DR ,  GROENING CARSTEN DR ,  RUGE BERND DR

IPC: C07D233/58 ,  B01J21/12 ,  B01J27/16 ,  C07D233/54 ,  C07D233/68 ,  C07D233/90 ,  C07D233/91 ,  C07D233/92 ,  C07D235/06 ,  C07D235/08 ,  C07D235/04 ,  C07D473/00 ,  C07D487/04

Abstract: Preparation of substituted imidazole derivatives of formula (I) comprises reaction of an imidazole of formula (II) with a compound of formula R4OR5 (III) at 200-550 degrees C in the presence of a catalyst containing oxides or phosphates of one or metals of the 2nd, 3rd and 4th main periods and the 4th transition period, optionally in the presence of phosphoric acid or phosphate esters. R1-R3 = H, halo, NO2, CN or 1-20C hydrocarbon (optionally mono- or poly-halogenated); or R1+R2 complete a 3-20C cyclic hydrocarbon optionally containing 1-3 heteroatoms from N, O or S (optionally mono- to poly-substituted by halo or 1-8C alkyl); R4 = 1-20C hydrocarbon (optionally mono- or poly-halogenated); R5 = R4 or H.

公开(公告)号：DE3715753A1

公开(公告)日：1988-11-24

申请号：DE3715753

申请日：1987-05-12

Applicant: BASF AG

Inventor： HOELDERICH WOLFGANG DR ,  SCHNEIDER KURT DR ,  RUGE BERND DR

IPC: C07D487/08 ,  B01J29/06

公开(公告)号：DE3881957D1

公开(公告)日：1993-07-29

申请号：DE3881957

申请日：1988-04-27

Applicant: BASF AG

Inventor： HOELDERICH WOLFGANG DR ,  SCHNEIDER KURT DR ,  RUGE BERND DR

IPC: C07D487/08

Abstract: Prodn. of 1,4-diazabicyclo(2,2,2)octanes of formula (I) is effected by contacting a piperazine derivs. of formula (II) with an aluminosilicate zeolite (III): R1 and R2 = H, 1-4C alkyl or 2-4C alkenyl; R3 = H, CH2CH2OH or CH2CH2NH2; X = OH or NH2. (III) is synthesises in the presence of an aq. hexamethylenediamine (HMDA), diaminopropane or triethylenetetramine soln. without addn. of alkali. The starting material comprises 1-(2-hydroxyethyl) piperazine (IIa) and/or 1,4-bis(2-hydroxyethyl)piperazine (IIb). The catalyst is a pentasil-type zeolite opt. modified with rare earths, transition metals or P cpds. The reaction is effected in the gas phase at 300-450 deg.C.

公开(公告)号：DE3161125D1

公开(公告)日：1983-11-10

申请号：DE3161125

申请日：1981-07-13

Applicant: BASF AG

Inventor： RUGE BERND DR

IPC: C07C45/63 ,  C07C51/29 ,  C07C63/04 ,  C07C63/70