公开(公告)号：CA2304466A1

公开(公告)日：1999-04-15

申请号：CA2304466

申请日：1998-10-06

Applicant: BASF AG

Inventor： HOCKLEY MICHAEL ,  ARNOLD LEE D ,  TURNER ALLYSON ,  BARLOZZARI TERESA ,  RAFFERTY PAUL ,  XU YAJUN

IPC: C07D231/54 ,  A61K31/415 ,  A61K31/416 ,  A61K31/4427 ,  A61K31/4439 ,  A61P1/02 ,  A61P1/04 ,  A61P9/00 ,  A61P9/10 ,  A61P15/00 ,  A61P17/06 ,  A61P19/00 ,  A61P19/02 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D401/04 ,  C07D403/04

Abstract: Chemical compounds that are derivatives of indeno1,2-c!pyrazole are inhibitors of tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell proliferation is a factor. Compounds of this invention also inhibit the induction of vascular hyperpermeability and the associated formation of edema, ascites, and exudates.

公开(公告)号：AU9603998A

公开(公告)日：1999-04-27

申请号：AU9603998

申请日：1998-10-06

Applicant: BASF AG

Inventor： ARNOLD LEE D ,  XU YAJUN ,  BARLOZZARI TERESA ,  RAFFERTY PAUL ,  HOCKLEY MICHAEL ,  TURNER ALLYSON

IPC: A61K31/415

公开(公告)号：AU4037800A

公开(公告)日：2000-10-23

申请号：AU4037800

申请日：2000-03-28

Applicant: BASF AG

Inventor： DOYLE KEVIN J ,  RAFFERTY PAUL ,  STEELE ROBERT W ,  TURNER ALLYSON ,  WILKINS DAVID J ,  ARNOLD LEE D

IPC: A61K31/416 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/5377 ,  A61P1/04 ,  A61P3/10 ,  A61P7/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P11/00 ,  A61P15/18 ,  A61P17/02 ,  A61P17/06 ,  A61P19/00 ,  A61P19/02 ,  A61P27/02 ,  A61P27/06 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/08 ,  A61P43/00 ,  C07D231/54 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D495/04 ,  C07D521/00

Abstract: This invention relates to compounds formula (I) and pharmaceutically acceptable salts thereof which are inhibitors of protein kinase activity, to pharmaceutical compositions containing these pyrazoles and to processes for preparing these pyrazoles.