公开(公告)号：BG64564B1

公开(公告)日：2005-07-29

申请号：BG10275598

申请日：1998-09-08

Applicant: BASF AG

Inventor： SALFELD JOCHEN ,  ALLEN DEBORAH ,  KAYMAKCALAN ZEHRA ,  LABKOVSKY BORIS ,  MANKOVICH JOHN ,  MCGUINNESS BRIAN ,  ROBERTS ANDREW ,  SAKORAFAS PAUL ,  HOOGENBOOM HENDRICUS ,  SCHOENHAUT DAVID ,  VAUGHAN TRISTAN ,  WHITE MICHAEL ,  WILTON ALISON

IPC: C12N15/09 ,  A61K31/00 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/505 ,  A61K31/517 ,  A61K31/52 ,  A61K31/529 ,  A61K31/57 ,  A61K31/573 ,  A61K31/675 ,  A61K38/00 ,  A61K38/04 ,  A61K38/16 ,  A61K39/39 ,  A61K39/395 ,  A61P1/00 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P7/00 ,  A61P7/04 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P11/00 ,  A61P11/16 ,  A61P13/12 ,  A61P17/00 ,  A61P17/02 ,  A61P19/02 ,  A61P19/06 ,  A61P25/00 ,  A61P27/02 ,  A61P29/02 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P33/06 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P39/02 ,  C07K16/24 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08 ,  G01N33/53 ,  G01N33/543 ,  G01N33/564 ,  G01N33/576 ,  G01N33/68 ,  C12N15/13 ,  C12N15/64

Abstract: The invention relates to human antibodies, preferably recombinant human antibodies which are specifically bound to human tumour necrotic factor alpha(TNFalpha). The antibodies have high afinity to hTNFalpha, e.g. Kd = 10-8 M or less, low hTNFalpha dissociate velocity, e.g. Koff = 10-3sec-1 or less, and neutralize the hTNFalpha activity in vitro and in vivo. Antibody of this invention can be an antibody with its full length or its antigene-binding part. The antibodies or parts thereof are applicable for the detection of hTNFalpha and for the inhibition of hTNFalpha activity, for example in patients suffering from indispositions where the hTNFalpha activity is harmfull. The invention also relates to nucleinic acids, vectors and host cells for the expression of recombinant human antibodies and to methods for their synthetization.

公开(公告)号：BG64776B1

公开(公告)日：2006-03-31

申请号：BG10753798

申请日：1998-09-08

Applicant: BASF AG

Inventor： SALFELD JOCHEN ,  ALLEN DEBORAH ,  KAYMAKCALAN ZEHRA ,  LABKOVSKY BORIS ,  MANKOVICH JOHN ,  MCGUINNESS BRIAN ,  ROBERTS ANDREW ,  SAKORAFAS PAUL ,  HOOGENBOOM HENDRICUS ,  SCHOENHAUT DAVID ,  VAUGHAN TRISTAN ,  WHITE MICHAEL ,  WILTON ALISON

IPC: C07K16/26 ,  C12N15/09 ,  A61K31/00 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/505 ,  A61K31/517 ,  A61K31/52 ,  A61K31/529 ,  A61K31/57 ,  A61K31/573 ,  A61K31/675 ,  A61K38/00 ,  A61K38/04 ,  A61K38/16 ,  A61K39/39 ,  A61K39/395 ,  A61P1/00 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P7/00 ,  A61P7/04 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P11/00 ,  A61P11/16 ,  A61P13/12 ,  A61P17/00 ,  A61P17/02 ,  A61P19/02 ,  A61P19/06 ,  A61P25/00 ,  A61P27/02 ,  A61P29/02 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P33/06 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P39/02 ,  C07K16/24 ,  C12N1/21 ,  C12N5/10 ,  C12N15/14 ,  C12N15/64 ,  C12P21/08 ,  G01N33/53 ,  G01N33/543 ,  G01N33/564 ,  G01N33/576 ,  G01N33/68

Abstract: The invention relates to a method for the inhibition of human TNFalpha activity by using isolated human antibody or its antigen-connection part. This property to inhibit TNFalpha finds application to produce medicaments for the treatment of diseases wherein the hTHFalpha activity is detrimental.