公开(公告)号：KR820001307B1

公开(公告)日：1982-07-21

申请号：KR780002191

申请日：1978-07-14

Applicant: BASF AG

Inventor： WAECHTER P ,  GUTSCHE K ,  KOHLMANN W

IPC: A61K31/505 ,  C07D239/48

Abstract: Title compd. I (R1,R2,R3 = H, Me, MeO, Cl; R4 = C1-6 alkyl, benzyl; R5,R6 = H, C1-4 alkyl, benzyl, Ph, cyclohexyl, furfuryl), useful as antibiotics, were prepd. by reacting compd. II with amine(III). Thus, 16.2 g N-[4-amino-5-(3,4,5-trimethoxybenzyl)-pyrimidin-2-yl -acetamido ethyl ester was dissolved in 120 ml pyridine, inwhich 14 ml satd. ammonium soln. (dissolved in EtOH) was added and stirred at 10≦̸C for 12 hr, vacuum concentrated, and recrystallized to give 8.6g N-[4-amino-5-(3,4,5-trimethoxybenzyl) -pyrimidin -2-yl acetamidine(m.p. 207≦̸C).