公开(公告)号：ES2278418T3

公开(公告)日：2007-08-01

申请号：ES98942624

申请日：1998-07-25

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  WORZ OTTO ,  FRETSCHNER ERICH ,  HANSEN HANSPETER ,  MULLER ALBRECHT ,  BENZ KURT

IPC: C07D285/16 ,  C07D285/24

Abstract: Un proceso para preparar 3-isopropil-1H-2, 1, 3-benzotiadiazin-4(3H)-ona 2, 2-dióxido (I) o una sal de I Caracterizado porque comprende la reacción simultánea de ácido antranílico de isopropilamida II Con trióxido de azufre con ácido clorosulfónico en presencia de una base orgánica o con aductos de trióxido de azufre y bases orgánicas y oxicloruro de fósforo a 50°C hasta la temperatura de reflujo, seguida, si se desea, por la conversión a sus sales.

公开(公告)号：SK282808B6

公开(公告)日：2002-12-03

申请号：SK1512000

申请日：1998-07-25

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  WORZ OTTO ,  FRETSCHNER ERICH ,  HANSEN HANSPETER ,  MULLER ALBRECHT ,  BENZ KURT

IPC: C07D285/24 ,  C07D285/16

Abstract: The invention relates to a method for the production of 3-isopropyl-1H-2,1,3-benzothiazine-4(3H)-one-2,2-dioxide (I) or its salt. The method is characterized in that anthranilic acid isopropylamide (II) is reacted simultaneously with sulphur trioxide or chlorosulphonic acid in the presence of an organic base, or with sulphur trioxide adducts on organic bases, and phosphoroxychloride at 50 °C until reflux temperature, and then optionally transformed into their salts.

公开(公告)号：AU9069198A

公开(公告)日：1999-03-08

申请号：AU9069198

申请日：1998-07-25

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  WORZ OTTO ,  FRETSCHNER ERICH ,  HANSEN HANSPETER ,  MULLER ALBRECHT ,  BENZ KURT

IPC: C07D285/24 ,  C07D285/16

Abstract: A process for preparing 3-isopropyl-1H-2,1,3-benzothiadiazin-4 (3H)-one 2,2-dioxide (I) or a salt of Iwhich comprises reacting anthranilic isopropylamide IIsimultaneously with sulfur trioxide or chlorosulfonic acid in the presence of an organic base or with adducts of sulfur trioxide and organic basesandphosphorus oxychloride at from 50° C. to the reflux temperature, followed, if appropriate, by conversion into its salts, is described.

公开(公告)号：AU748904B2

公开(公告)日：2002-06-13

申请号：AU9069198

申请日：1998-07-25

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  WORZ OTTO ,  FRETSCHNER ERICH ,  HANSEN HANSPETER ,  MULLER ALBRECHT ,  BENZ KURT

IPC: C07D285/24 ,  C07D285/16

Abstract: A process for preparing 3-isopropyl-1H-2,1,3-benzothiadiazin-4 (3H)-one 2,2-dioxide (I) or a salt of Iwhich comprises reacting anthranilic isopropylamide IIsimultaneously with sulfur trioxide or chlorosulfonic acid in the presence of an organic base or with adducts of sulfur trioxide and organic basesandphosphorus oxychloride at from 50° C. to the reflux temperature, followed, if appropriate, by conversion into its salts, is described.

公开(公告)号：SK1512000A3

公开(公告)日：2000-07-11

申请号：SK1512000

申请日：1998-07-25

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  WORZ OTTO ,  FRETSCHNER ERICH ,  HANSEN HANSPETER ,  MULLER ALBRECHT ,  BENZ KURT

IPC: C07D285/24 ,  C07D285/16

Abstract: The invention relates to a method for the production of 3-isopropyl-1H-2,1,3-benzothiazine-4(3H)-one-2,2-dioxide (I) or its salt. The method is characterized in that anthranilic acid isopropylamide (II) is reacted simultaneously with sulphur trioxide or chlorosulphonic acid in the presence of an organic base, or with sulphur trioxide adducts on organic bases, and phosphoroxychloride at 50 C until reflux temperature, and then optionally transformed into their salts.

公开(公告)号：CA2301194C

公开(公告)日：2007-05-15

申请号：CA2301194

申请日：1998-07-25

Applicant: BASF AG

Inventor： HANSEN HANSPETER ,  MULLER ALBRECHT ,  WORZ OTTO ,  MERKLE HANS RUPERT ,  BENZ KURT ,  FRETSCHNER ERICH

IPC: C07D285/16 ,  C07D285/24

Abstract: The invention relates to a method for the production of 3-isopropyl-1H-2,1,3 - benzothiazine-4(3H)-one-2,2-dioxide (I) or its salt. The method is characterized in that anthranilic acid isopropylamide (II) is reacted simultaneously with sulphur trioxide or chlorosulphonic acid in the presence of an organic base, or with sulphur trioxide adducts on organic bases, and phosphoroxychloride at 50 .degree.C until reflux temperature, and then optionally transformed into their salts.

公开(公告)号：NZ502659A

公开(公告)日：2003-06-30

申请号：NZ50265998

申请日：1998-07-25

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  WORZ OTTO ,  FRETSCHNER ERICH ,  HANSEN HANSPETER ,  MULLER ALBRECHT ,  BENZ KURT

IPC: C07D285/24 ,  C07D285/16

Abstract: A simple cost-effective process for preparing 3-isopropyl-1H-2,1,3-benzothiadiazin-4(3H)-one 2,2-dioxide (I) which comprises reacting anthranilic isopropylamide (II) simultaneously with sulfur trioxide or chlorosulfonic acid in the presence of an organic base or with adducts of sulfur trioxide and organic bases and phosphorus oxychloride at from 50 C. to the reflux temperature, followed if appropriate, by conversion into its salts.

公开(公告)号：EA002121B1

公开(公告)日：2001-12-24

申请号：EA200000227

申请日：1998-07-25

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  WORZ OTTO ,  FRETSCHNER ERICH ,  HANSEN HANSPETER ,  MULLER ALBRECHT ,  BENZ KURT

IPC: C07D285/24 ,  C07D285/16

Abstract: Способполучения 3-изопропил-1Н-2,1,3-бензотиадиазин-4(3Н)-он-2,2-диоксидаформулы (I) илиегосолиотличающийсятем, чтоизопропиламидантраниловойкислоты IIподвергаютвзаимодействиюс трехокисьюсерыилис хлорсульфокислотойв присутствииорганическогооснованияилис аддуктамитрехокисисерыи органическихоснований, иодновременнос хлорокисьюфосфорапритемпературеот 50°Сдотемпературыкипенияс обратнымхолодильникоми потом, необязательно, переводятв егосоли.

公开(公告)号：CA2301194A1

公开(公告)日：1999-02-25

申请号：CA2301194

申请日：1998-07-25

Applicant: BASF AG

Inventor： FRETSCHNER ERICH ,  HANSEN HANSPETER ,  WORZ OTTO ,  MULLER ALBRECHT ,  BENZ KURT ,  MERKLE HANS RUPERT

IPC: C07D285/24 ,  C07D285/16

Abstract: The invention relates to a method for the production of 3-isopropyl-1H-2,1,3-benzothiazine-4(3H)-one-2,2-dioxide (I) or its salt. The method is characterized in that anthranilic acid isopropylamide (II) is reacted simultaneously with sulphur trioxide or chlorosulphonic acid in the presence of an organic base, or with sulphur trioxide adducts on organic bases, and phosphoroxychloride at 50 ~C until reflux temperature, and then optionally transformed into their salts.